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1、Unit 3,Gene Therapy,Word Formation,aden/o (gland) e.g. adenovirus -ase (enzyme) leuk/o (white) e.g. leukemia syn- (together with) e.g. syndrome poly- (multiple) mono- (single) e.g. monocyte homo- (the same) e.g. homograft homosexuality chrom/o (colour) e.g. chromosome -some (body) e.g. somatic,retr/
2、o ( at the back, behind) e.g. retrovirus path/o (illness) e.g. pathogen -genic (produced by) e.g. pathogenic lip/o (fat) e.g. liposome auto- (self) e.g. autonomy, autonomously tox/o (toxin) e.g. toxicity arthr/o (joint) e.g. arthritis fibr/o (fibre) e.g. fibrosis,Questions to consider:,What is a gen
3、e ? What is gene therapy ? Give your personal comment on gene therapy.,What is a gene ? the basic unit of genetic material, which is carried at a particular place on a chromosome. Originally it was regarded as the unit of inheritance and mutation but is now usually defined as a sequence of DNA or RN
4、A that acts as the unit controlling the formation of a single polypeptide chain.,What is gene therapy? Gene therapy is an experimental technique that uses genes to treat or prevent disease. In the future, this technique may allow doctors to treat a disorder by inserting a gene into a patients cells
5、instead of using drugs or surgery. Researchers are testing several approaches to gene therapy, including:,Replacing a mutated gene that causes disease with a healthy copy of the gene. Inactivating, or “knocking out,” a mutated gene that is functioning improperly. Introducing a new gene into the body
6、 to help fight a disease.,Although gene therapy is a promising treatment option for a number of diseases (including inherited disorders, some types of cancer, and certain viral infections), the technique remains risky and is still under study to make sure that it will be safe and effective. Gene the
7、rapy is currently only being tested for the treatment of diseases that have no other cures.,Gene therapy is the introduction of genetic material into cells for therapeutic purposes. Recent scientific breakthroughs in the genomics field and our understanding of the important role of genes in disease
8、has made gene therapy one of the most rapidly advancing fields of biotechnology with great promise for treating inherited and acquired diseases.,Many human diseases are caused by the absence or inappropriate presence of a protein. Biotechnologys first promise was to isolate and produce these natural
9、 proteins through genetic engineering and recombinant technology. The protein could then be administered to patients in order to compensate for its absence. Because proteins are not orally available, biotech companies focused on innovative methods of protein delivery and sustained drug delivery.,Tod
10、ay, gene therapy is the ultimate method of protein delivery, in which the delivered gene enters the bodys cells and turns them into small “factories“ that produce a therapeutic protein for a specific disease over a prolonged period. As gene therapy has moved from the laboratory into the clinic, seve
11、ral issues have emerged as central to the development of this technology: gene identification, gene expression and gene delivery.,The types of gene therapy described thus far all have one factor in common: that is, the tissues being treated are somatic (somatic cells include all the cells of the bod
12、y, excluding sperm cells and egg cells). In contrast to this is the replacement of defective genes in the germline cells (which contribute to the genetic heritage of the offspring).,Gene therapy in germline cells has the potential to affect not only the individual being treated, but also his or her
13、children as well. Germline therapy would change the genetic pool of the entire human species, and future generations would have to live with that change. In addition to these ethical problems, a number of technical difficulties would make it unlikely that germline therapy would be tried on humans in
14、 the near future.,Understanding the Text,Para. 1 gene chromosome physical heredity sequences of bases encode / encoded genetic disorder,Para. 2 defective/faulty genes nonspecific location a nonfunctional gene genome swap: to exchange 置换，交换， 掉换 e.g. Id swap my job for hers any day. 我愿随时和她调换工作。 homolo
15、gous recombination selective reverse mutation regulation,Para. 3 carrier / vector therapeutic gene target cell genetically altered evolve a way of：develop a way of 具备途径 encapsulate：把密封于 ；压缩 capability manipulate: to use or control sth. with skill,Para. 4 unload into: release into generation restore
16、to e.g.,治疗性基因生成新一代功能性蛋白质使靶细胞 恢复到正常状态。,Para. 6 retroviruses:逆转录酶病毒 double-stranded:双链 integrated:整合 host cell,Para. 8 single-stranded DNA viruses: 单链DNA病毒 chromosome 19: 19号染色体,The 24 human chromosome territories during prometaphase in fibroblast cells.,Para. 9 herpes simplex virus type 1: I型单纯疱疹 cold sores 感冒疮; 唇疱疹 Cold sores are small, painful, fluid-filled blisters or sores that appear on the lips, mouth, or nose that are caused by a herpes simplex virus infection. T
