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1、Nonatology: Neonatal Respiratory Distress,Lecture Points,Neonatal pulmonary function Clinical Manifestation The main causes Main types of the disease Case discussion and presentation Summary and conclusion,Pulmonary function of the newborns in particular,Relative small capacity of the lungs： limited
2、 reserved volume poor compensation, likely to be distressed Respiratory on abdomen and diaphragmatic movement Distension: likely to be respiratory distressed pulmonary surfactant (PS) relative in small amount in preterms and easily to be deficiency Diseased lungs trends poor compliance and even ARDS
3、,Neonatal Respiratory Distress,General picture commonly occurs during neonatal period caused by various pathogeneses breath or 、irregular, apnea With or without retraction at breathing, suprasternal and intercostal usually with cyanosis more or less,Causation of neonatal respiratory distress,Upper r
4、espiratory tract： choana, macrotongue, micrognathia Larynx/throat and trachea：intenerate pulmonary disease： inflammation、abnormality or hypogenesis others：congenital heart disease metabolic problems, CNS caused,Pathophysiology in neonatal respiratory distress,hypoxic and /or hypoventilation hypoxemi
5、a, PCO2 respiration center peripheral biochemical sensors breath or 、irregular, apnea,Neonatal Respiratory Distress,Hyaline Membrane Disease （HMD、RDS) Neonatal infectious Pneumonia Meconium Aspiration Syndrome (MAS) for differentiation,Hyaline Membrane Disease（HMD/RDS）,Clinical manifestation preterm
6、s normal at birth, respiratory distressed in several hours after birth progressively developing and deterioration self cured process during the sickness,Clinical manifestation After birth commonly seen, intrauterine infectious pneumonia relatively less seen Occurring in neonates with different GAs a
7、nd ages General appearance of infection Various in severity of respiratory distress Blood-gas：PaO2 、PaCO2 ,Neonatal infectious Pneumonia,Meconium Aspiration Syndrome (MAS),Clinical manifestation Terms and post-terms commonly seen History of intrauterine distress amniotic fluid stained by meconium Lo
8、wer Apgars score Distress occurs soon after birth Tachypnea and withdrawal at breathing Blood-gas：PaO2 , PaCO2 and acidosis,CXR:HMD,CXR: pneumonia,CXR:MAS,CXR: MAS,Clinical management for neonatal respiratory distress,Monitoring General appearance：T; response, skin color, feeding tolerance respirati
9、on（frequency, pattern and apnea） Other systems: HR, liver, abdomen Blood-gas, Pa O2 、SaO2,Clinical management for neonatal respiratory distress,Oxygen therapy Nasal tube Mask and tent Pressed facial mask Attention! fio2 O2 concentration ROP,CLD/BPD,Clinical management for neonatal respiratory distre
10、ss,Mechanical ventilation Target：early intervention and early withdraw Indication： persistent cyanosis under oxygen therapy Remarkable SaO2 PaO2 and /or PaCO2 indicated by ABG,Clinical management for neonatal respiratory distress,Mechanical ventilation Ventilation modes and parameters Continuous pos
11、itive airway pressure (CPAP)： 4 - 8 cmH2O; Assistant/control (A/C) ： PIP 15-25 cmH2O；RR 25-35； I/E：1：1.5-2.5；PEEP： 4 - 12 cmH2O Pressure support ventilation ( PSV )：6-10 cmH2O High frequency oxillation ventilation: HFOV,Clinical management for neonatal respiratory distress,Medication antibiotics pen
12、icillin: 10-40 万u/kg/d ampicillin: 50-75mg /kg/d cephalosporin: 25-50mg /kg/d PS: 80-120 mg /kg, 1 to 2 dose,Clinical management for neonatal respiratory distress,Keep the baby warm Incubator Radiator Stable room tempereture,Clinical management for neonatal respiratory distress,Clinical nutrition Feeding: Breast milk/Formulas decreasing volume feeding as needed Parenteral nutrition（T/PPN）,Thanks for listening,Questions please?,
