《ABD活性因子与免疫系统相关研究》由会员分享，可在线阅读，更多相关《ABD活性因子与免疫系统相关研究（17页珍藏版）》请在金锄头文库上搜索。
1、美源康富A.B.D活性因子与免疫系统相关研究美源康富ABD活性因子为免疫细胞提供“食粮”，增强免疫反应美源康富ABD活性因子临床证明能够促进健康人体白细胞合成更多谷胱甘肽，为白细胞的分化和增生提供“食粮”，促进B细胞产生抗体，增加杀手T细胞的杀伤力，明天提高各项免疫指标。美源康富ABD活性因子中和自由基，修复炎症损伤免疫反应过程中，白细胞会产生大量过氧化物去消灭抗原。这些过氧化物当然也会伤害周围正常的组合和细胞，包括免疫细胞本身。美源康富ABD活性因子临床证明能够促进人体所有细胞合成更多谷胱甘肽，谷胱甘肽是细胞的“抗氧化剂之王”，能快速中和炎症反应中产生的大量自由基，将炎症对正常组织的损伤降到
2、最低，加速人体的自愈过程。美源康富ABD活性因子抗炎镇痛过度的炎症反应对人体的伤害有时候比益处更大，比如慢性炎症和通风，炎症最终成了疾病的症状，带来无法忍受的疼痛。美源康富ABD活性因子调节前列腺素的合成，抑制COXII的活性，从而达到消炎镇痛的效果。1. Influence of Dietary Lactalbumin Hydrolysate on the Immune System of Mice and Resistance to SalmonellosisG. Bounous, M.M. Stevenson*, P.A.L. KongshavnCentre hospitalier un
3、iversitaire, Sherbrooke, Quebec, Canada; *Montreal General Hospital Research Institute and McGill University, Montreal, Quebec, CanadaTHE JOURNAL OF INFECTIOUS DISEASES, 144: 281, 1981Abstract: In the present study we investigated the effect of four weeks of treatment with a diet containing lactalbu
4、min hydrolysate (LAH: Nestl, Vevey, Switzerland) on the immune response of C3H/HeN mice. Our data indicate that it was possible to increase the level of this type of protein in the diet above the minimum requirement (12% LAH) and thus produce augmented humoral immune responsiveness and resistance to
5、 salmonellosis.Lactalbumin = Whey Protein Concentrate研究主题使用美源康富ABD活性因子对小鼠免疫系统和抗沙门氏感染能力的影响研究目的本实验是为了研究向C3H/HeN小鼠喂食美源康富ABD活性因子4周后，对其免疫系统的影响。研究结果我们数据表明，提高饲料中ABD活性因子的含量，能够影响体液免疫反应和抵抗沙门氏感染的能力。表1 使用4种不同配方的蛋白喂食C3H/HeN小鼠4周后，对小鼠注射沙门氏菌，检测小鼠的免疫反应指标以及存活率。如表所示，用沙门氏菌免疫接种后，各蛋白饲料组的小鼠脾脏重量都有所增加，证实了脾脏在接种后的免疫反应。斑块生成细胞的
6、数量在食用20%和28%ABD活性因子时比其它两组明显增加；各蛋白组的吞噬细胞数量在接种后都 远大于未接种时，20%ABD活性因子组的吞噬细胞数量大于其他三组。12%ABD活性因子 组的小鼠存活率高于普通蛋白组，当ABD活性因子含量增加为28%时，存活率提升现象更 明显。说明ABD活性因子有增强免疫力的效果，这种效果与食用浓度有关。免疫反应指标22%普通蛋白组12% ABD20% ABD28% ABD脾脏重量/体重%（接种）55.22.048.01.650.2254.42.6脾脏重量/体重%（未接种）37.50.941.12.449.91.850.60.6斑块生成细胞数量9410.0595.1
7、1559.215911.9吞噬细胞数量（接种）1235064811189185139950912094198吞噬细胞数量（未接种）6271040030621181595767天存活率%0100010014天存活率%03006021天存活率%0707文献来源 G. Bounous, M.M. Stevenson, P.A.L. Kongshavn，传染病期刊，1981年114期281页。 2. Influence of Dietary Protein Type on the Immune System of MiceG. Bounous, L. Ltourneau and P.A.L. Kong
8、shavnCentre hospitalier universitaire, Sherbrooke, Quebec, Canada; J1H 5N4 and Montreal General Hospital Research Institute and Department of Physiology, McGill University, Montreal, Quebec, Canada, H3G1Y6J. NUTR. 113: 1415-1421, 1983Abstract: The effect of graded amounts of dietary lactalbumin (L),
9、 casein (C), soy (S), wheat (W) protein and Purina rodent chow (stock diet) on the immune responsiveness of C3H/HeN mice has been investigated by measuring the specific humoral immune response to sheep red blood cells (SRBC), and horse red blood cells (HRBC) as well as the nonspecific splenic cell r
10、esponsiveness to phyto-hemagglutinin (PHA) and concanavalin A (Con A) after stimulation with Myco-bacterium bovis, strain BCG. The nutritional efficiency of these diets was normal and similar. The immune response of mice fed the L diets, was found to be almost five times higher than that of mice fed
11、 the corresponding C diets. The humoral immune response of mice fed C, S, and W diets was substantially lower than that of mice fed stock diet, whereas that of mice fed L diet was higher. The above-described immune effect of all tested proteins was obtained at 20 g/100 g concentration with no furthe
12、r increments with 30- and 40 g/100 g protein in the diet. Mitogen responsiveness to PHA and Con A in L diet-fed mice was only slightly higher than that of C diet-fed mice. Little difference in immune responses was noted among mice fed C, S or W protein diets. The principal factor responsible for the
13、 observed immune effect does not appear to be the availability or concentration of single essential amino acids but rather the composite effect of the specific amino acid distribution in the protein.研究主题服用美源康富ABD活性因子对小鼠免疫系统的影响研究内容选用C3H/HeN小鼠，分别喂食含20%乳白蛋白、酪蛋白、大豆蛋白和小麦蛋白饲料和普通饲料，检测小鼠对羊血红细胞和马血红细胞的特 定免疫反应
14、，以及肉毒杆菌刺激的脾细胞对植物凝聚素（PHA）和伴刀 豆球蛋白A（ConA）的非特异反应。不同饲料的营养成分相似。研究结果ABD活性因子组所有小鼠的免疫反应比酪蛋白组高近乎5倍，体液免疫反应比普通饲料组高，而其它三组的体液免疫反应比普通饲料组低。以上反应是在蛋白含量20%情况下观察到的，当含量增加到30%和40%时，反应没有进一步增强。ABD活性因子组的有丝分裂素对PHA和ConA的反应比 酪蛋白组稍高。酪蛋白组、大豆蛋白组和小麦蛋白组的免疫反应几乎无差别。每个脾脏的血小板生成细胞数量LLLLCCCC图1 分别选用两种不同品系的小鼠，用酪蛋白（C）、12%和28%浓度的ABD活性因子（L）饲
15、料喂食4周，绵羊红细胞刺激小鼠脾脏产生免疫反应，检测小鼠脾脏斑块生成细胞（PFC）的数量。ABD活性因子组的PFC数量明显高于酪蛋白组，这一现象在浓度28%时更显著。研究结论这种对免疫力的影响似乎不是某种单一氨基酸的作用，而是几种特定氨基酸在蛋白中的分布造成的。文献来源 G. Bounous, L. Ltourneau and P.A.L. Kongshavn ，营养学期刊，1983年113期1415-1421页。 3. Mechanism of Altered B-Cell Response Induced By Changes in Dietary Protein Type in MiceG. Bounous, N. Shenouda,1 P.A.L. Kongshavn2 and D.G. Osmond1Department of Surgery, Centre Hospitalier Universitaire, Sherbrooke, Quebec, Canada, J1H 5N4; 1Department of Anatomy, McGill University, Montreal, Quebec, Canada, H3A2B2; and
