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1、SICENCE 新闻发布 作者：杨丽君 稿号：N20120901001缺氧缺血性脑损伤修复的分子调控缺氧缺血性脑损伤修复的分子调控 少突胶质细胞系基因 1 是少突胶质细胞的重要转录因子，在缺氧缺血性脑损伤髓鞘修复过程发挥关 键作用。有研究发现，微小 RNA-9 可以与少突胶质细胞系基因 1 基因不完全互补地结合，提示两者 直接可能存在相互关系，但微小 RNA-9 是否对于少突胶质细胞系基因 1 具有调控作用目前尚无定论。 中国首都医科大学附属北京友谊医院杨丽君博士所在课题组进行的一项研究，建立缺氧缺血的离体全 脑脑片模型，然后将微小 RNA-9 转染入脑片，观察其对少突胶质细胞系基因 1 基因
2、的表达模式的影 响。结果证实，缺氧缺血性脑损伤时微小 RNA-9 可能对脑组织少突胶质细胞系基因 1 的表达存在负 性调控作用。作者认为，文章结果可为缺氧缺血性脑损伤修复的分子调控机制的研究提供新证据。文章发表在中国神经再生研究（英文版） 杂志 2014 年 3 月第 5 期。免疫荧光染色显示，微小 RNA-9转染后未成熟新生大鼠缺氧缺糖脑片脑组织细胞呈现明显的绿色荧光(质粒自带的GFP 基因，箭头所指)Article: “ Negative regulation of miRNA-9 on oligodendrocyte lineage gene 1 during hypoxic-ische
3、mic brain damage,“ by Lijun Yang, Hong Cui, Ting Cao (Department of Pediatrics, Beijing Friendship Hospital, Capital Medical University, Beijing, China)Yang LJ, Cui H, Cao T. Negative regulation of miRNA-9 on oligodendrocyte lineage gene 1 during hypoxic-ischemic brain damage. Neural Regen Res. 2014
4、;9(5):513-518. 欲获更多资讯：Neural Regen Res Molecular regulation of hypoxic-ischemic brain damageOligodendrocyte lineage gene 1 (Olig1) plays a key role in hypoxic-ischemic brain damage and myelin repair. miRNA-9 is involved in the occurrence of many related neurological disorders. Bioinformatics analysi
5、s demonstrated that miRNA-9 complementarily, but incompletely, bound oligodendrocyte lineage gene 1, but whether miRNA-9 regulates oligodendrocyte lineage gene 1 remains poorly understood. Dr. Lijun Yang and co-workers from Beijing Friendship Hospital, Capital Medical University in China prepared wh
6、ole brain slices from a rat model of oxygen-glucose deprivation and explored dynamic expression pattern of Olig1 during hypoxic-ischemic brain damage and after miRNA-9 transfection. Results from their study showed that miRNA-9 possibly negatively regulated oligodendrocyte lineage gene 1 in brain tis
7、sues during hypoxic-ischemic brain damage. The relevant study has been reported in the Neural Regeneration Research (Vol. 9, No. 5, 2014). SICENCE 新闻发布 作者：杨丽君 稿号：N20120901001After miRNA-9 transfection, noticeable green fluorescence (plasmid with GFP gene, arrow)was found in brain tissue from neonata
8、l rats undergoing oxygen-glucose deprivation.Article: “ Negative regulation of miRNA-9 on oligodendrocyte lineage gene 1 during hypoxic-ischemic brain damage,“ by Lijun Yang, Hong Cui, Ting Cao (Department of Pediatrics, Beijing Friendship Hospital, Capital Medical University, Beijing, China)Yang LJ, Cui H, Cao T. Negative regulation of miRNA-9 on oligodendrocyte lineage gene 1 during hypoxic-ischemic brain damage. Neural Regen Res. 2014;9(5):513-518.
