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1、 Sigma - C5743 Sigma-Aldrich Corporation www.sigma- Page 1 of 5 SIGMA-ALDRICH Material Safety Data Sheet Version 3.1 Revision Date 06/19/2009 Print Date 05/31/2010 1. PRODUCT AND COMPANY IDENTIFICATION Product name : Cilastatin sodium salt Product Number : C5743 Brand : Sigma Company : Sigma-Aldrich
2、 3050 Spruce Street SAINT LOUIS MO 63103 USA Telephone : +18003255832 Fax : +18003255052 Emergency Phone # : (314) 776-6555 2. COMPOSITION/INFORMATION ON INGREDIENTS Formula : C16H25N2NaO5S Molecular Weight : 380.43 g/mol CAS-No. EC-No. Index-No. Concentration Sodium hydrogen R-R*,S*-(Z)-7-(2-amino-
3、2-carboxylatoethyl)thio-2-(2,2- dimethylcyclopropyl)carbonylaminohept-2-enoate 81129-83-1 279-694-4 - - 3. HAZARDS IDENTIFICATION Emergency Overview OSHA Hazards No known OSHA hazards HMIS Classification Health Hazard: 0 Flammability: 0 Physical hazards: 0 NFPA Rating Health Hazard: 0 Fire: 0 Reacti
4、vity Hazard: 0 Potential Health Effects Inhalation May be harmful if inhaled. May cause respiratory tract irritation. Skin May be harmful if absorbed through skin. May cause skin irritation. Eyes May cause eye irritation. Ingestion May be harmful if swallowed. Sigma - C5743 Sigma-Aldrich Corporation
5、 www.sigma- Page 2 of 5 4. FIRST AID MEASURES If inhaled If breathed in, move person into fresh air. If not breathing give artificial respiration In case of skin contact Wash off with soap and plenty of water. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anyt
6、hing by mouth to an unconscious person. Rinse mouth with water. 5. FIRE-FIGHTING MEASURES Flammable properties Flash point no data available Ignition temperature no data available Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special protective
7、 equipment for fire-fighters Wear self contained breathing apparatus for fire fighting if necessary. 6. ACCIDENTAL RELEASE MEASURES Personal precautions Avoid dust formation. Environmental precautions Do not let product enter drains. Methods for cleaning up Sweep up and shovel. Keep in suitable, clo
8、sed containers for disposal. 7. HANDLING AND STORAGE Handling Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire protection. Storage Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8 C Kee
9、p in a dry place. 8. EXPOSURE CONTROLS/PERSONAL PROTECTION Contains no substances with occupational exposure limit values. Personal protective equipment Respiratory protection Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or typ
10、e P1 (EN 143) dust masks. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Hand protection For prolonged or repeated contact use protective gloves. Sigma - C5743 Sigma-Aldrich Corporation www.sigma- Page 3 of 5 Eye protection S
11、afety glasses Hygiene measures General industrial hygiene practice. 9. PHYSICAL AND CHEMICAL PROPERTIES Appearance Form powder Safety data pH no data available Melting point no data available Boiling point no data available Flash point no data available Ignition temperature no data available Lower e
12、xplosion limit no data available Upper explosion limit no data available Water solubility no data available Partition coefficient: n-octanol/water log Pow: -1.177 10. STABILITY AND REACTIVITY Storage stability Stable under recommended storage conditions. Materials to avoid Strong oxidizing agents Ha
13、zardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, nitrogen oxides (NOx), Sulphur oxides, Sodium oxides 11. TOXICOLOGICAL INFORMATION Acute toxicity LD50 Oral - rat - 10,000 mg/kg Irritation and corrosion no data available Sensitisation no
14、data available Chronic exposure IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as a carcino
15、gen or potential carcinogen by ACGIH. Sigma - C5743 Sigma-Aldrich Corporation www.sigma- Page 4 of 5 NTP: No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP. OSHA: No component of this product present at levels great
16、er than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA. Signs and Symptoms of Exposure Drowsiness Potential Health Effects Inhalation May be harmful if inhaled. May cause respiratory tract irritation. Skin May be harmful if absorbed through skin. May cause skin irritation. Eyes May cause eye irritation. Ingestion May be h
