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1、<p><p>Bone and Cartilage Repair Bone and Cartilage Repair Yang Liang-liang ? General introduction of bone repair ? Scaffold-based TE strategies ? Scaffold materials ? Spontaneous regeneration ? Bone graft ? Bone transport Bone Graft Bone Graft Autografting Allogenic transplantati
2、on Synthetic bone substitutes metal calcium phosphate hydroxylapatite Typical scaffold-guided approach for tissue engineering (TE) non-immunogenic non-toxic biocompatiblebiodegradable easily manufactured Scaffold material Pore size SmallLarge Porous surface LargeSmall Cell charge MuchLittle Mechanic
3、al strength LowHigh Composite bioactive materials Nature original polymers Synthesis polymers Composite bioactive materials Calcium phosphates Hydroxylapatite Bioactive glasses (BAGs) Nature original polymers ProteinsPolysaccharides Synthesis polymers poly(-caprolactone) (PCL) poly(propylene fumarat
4、e) (PPF) poly(glycolic acid) (PGA) poly(lactic-co-glycolic acid) (PLGA) low mechanical property low thermal stability risk of immuno-rejection possible loss of biological properties lack of biological cues AdvantagesDisadvantages Natural Polymer low toxicity easily manufactured renewability cell adhesion low antigenicity Synthesis polymers tailored chemical property high elasticity various medical applications suitable mechanical properties low risks of infections Thats all, thank you! </p></p>
