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1、CholesterolSterol ToolkitPregnenolonProgesteronAldosteronCortisolCorticosteroneAndrostendioneTestosteronEstriol17 -Estradiol1, 25-DihydroxycholecalciferolCholic acidCovalent modification of proteinsPoly(ADP ribosyl) Polymerase (PARP)Poly(ADP ribosyl)polymerase(PARP)NADNicotinamidePoly(ADP ribosyl)po
2、lymerase(PARP)Poly(ADP ribosyl)chain elongationand branchingNicotinamideNADNADDNA polymerase DNA polymerase DNA polymerase OligosacharyltransferaseN-glycosylation pathway in ERMann-P-DolicholtransferasesFlippaseDolicholPDolicholPPDolicholPPDolicholPPDolicholPPGlcNAc-PtransferaseGlcNActransferaseDoli
3、cholPDolicholPPDolicholPPGDP-Mannosyl transferasesGlc-P-DolicholtransferasesDolicholPDolichol-pyrophofphataseCytosolER40S60SUTPCTPTMPPyrimidine Nucleotide InterconversionsUMPATPADPH2OUDPNucleosidemonophosphatekinaseATPADPNucleosidediphosphatekinaseATPADPCTPsynthaseRibonucleotidereductasedeoxyUDPNucl
4、eosidediphosphatephosphohydrolasedeoxyUMPThymidylatesynthaseN5,N10-MethyleneTHFDHFTTPNucleosidemonophosphatekinaseNucleosidediphosphatekinaseMyo-Inositol-3-phosphateIns(3)P1Biosynthesis and metabolism of phosphoinositidesGlucose 6-pgosphateIns(3)P1synthaseIns(3)P1phosphataseMyo-InositolInsPtdInssynt
5、hasePtdInsMyo-inositolkinasePtdIns-4-PPtdIns4-kinasePtdIns5-kinasePtdIns-4,5-P2PI3KPtdIns-3,4,5-P3PLCPLCPI3KPtdIns-3,4-P2Ins-1,3,4-P3Ins-1,3,4,5-P4Ins-1,4,5-P3PLCPTENPTENIns-1,4-P3PTENPTENFatty acidsynthase -ketoacylACP-synthaseFatty acids synthesisAcetyl CoAcarboxylaseATPADP + PiAcetyl CoAMalonyl C
6、oACitrateOxaloacetateATPADP + PiCitrate lyaseAcetyltransacylaseMalonyltransacylasePantetheine -ketoacylACP-reductasePantetheinePantetheine -hydroxyacylACP-dehydratasePantetheineEnoyl-ACPreductasePantetheineNADPHNADPNADPHNADPCholesterol de novo synthesis IIsoprenyl formationAcetoacetyl-CoAThiolaseHMG
7、-CoAsynthaseMevalonate3-Hydroxy-3-methylglutaryl-CoAMevalonatekinasePhosphomevalonatekinaseMevalonate-5-pyrophosphodecarboxylase5-Phosphomevalonate5-Pyrophosphomevalonate3-Isopentenylpyrophosphate3, 3-DimethylalylpyrophosphateIsomeraseHMG-CoAreductase2 NADPH2 NADPATPADPADPATPADPATPCholesterolBiosynt
8、hesis of bile acids7 -HydroxycholesterolSterol 7 hydroxylaseCYP7A17 -Hydroxy-4-cholesten-3-one3 -Hydroxystroid dehydrogenaseHSD3B77 , 12 -Dihydroxy-4-cholesten-3-oneSterol-12 -hydroxylaseCYP8B15 -Cholestan-3 , 7 , 12 -TriolOxosteroid-5 -reductaseAKR1D1Sterol 27-hydroxylaseCYP27A13 , 7 , 12 -Trihydro
9、xy-5 -cholestanoic acidCholic acidAKR1D1AKR1C45 -Cholestan-3 , 7 -diol12 -Deoxycholic acid3 -Hydroxy-steroid dehydrogenaseAKR1C4Biosynthesis of RNARNAPolymeraseBiosynthesis of DNADNAPolymerase-oxidationMitochondrial matrixIntermembranespacePalmitoyl carnitinePalmitoyl carnitinePalmitoyl CoAPalmitoyl
10、 CoATrans 2 enolopalmitoyl CoA3-Hydroxypalmitoyl CoA3-Ketopalmitoyl CoAMyristoyl CoAAcetyl-CoAPalmitoyl CoAPalmitatePalmitoyl CoAligaseATPAMPCarnitineacyltransferase ICarnitineCarnitineacyltransferase IIAcyl CoAdehydrogenaseEnoyl CoAhydratase3-Hydroxyacyl CoAdehydrogenaseCitric AcidCycleFADFADH2NADN
11、ADHCytoplasmH2OMyo-Inositol-3-phosphateIns(3)P1Phospho-myo-inositol Toolkit 2Myo-Inositol-3,4-diphosphateIns(3,4)P2Myo-Inositol-3,6-diphosphateIns(3,6)P2Myo-Inositol-3,4,6-triphosphateIns(3,4,6)P3Myo-Inositol-1,3,4-triphosphateIns(1,3,4,)P3Myo-Inositol-3,4,5,6-tetraphosphateIns(3,4,5,6)P4Myo-Inosito
12、l-1,4,5-triphosphateIns(1,4,5)P3Myo-Inositol-1,3,4,6-tetraphosphateIns(1,3,4,6)P4Myo-Inositol-1,3,4,5-tetraphosphateIns(1,3,4,5)P4Myo-Inositol-1,4,5,6-tetraphosphateIns(1,4,5,6)P4Myo-Inositol-1,2,3,4,6-pentaphosphateIns(1,2,3,4,6)P5Myo-Inositol-1,3,4,5,6-pentaphosphateIns(1,3,4,5,6)P5Myo-Inositol-1,
13、2,3,4,5-pentaphosphateIns(1,2,3,4,5)P5Myo-Inositol-1,2,4,5,6-pentaphosphateIns(1,2,4,5,6)P5Myo-Inositol-1,2,3,4,5,6-hexaphosphateIns(1,2,3,4,5,6)P6 (Phytic acid)Myo-Inositol-3-phosphateIns(3)P1Phospho-myo-inositol ToolkitMyo-Inositol-3,4-diphosphateIns(3,4)P2Myo-Inositol-3,6-diphosphateIns(3,6)P2Myo
14、-Inositol-3,4,6-triphosphateIns(3,4,6)P3Myo-Inositol-1,3,4-triphosphateIns(1,3,4,)P3Myo-Inositol-3,4,5,6-tetraphosphateIns(3,4,5,6)P4Myo-Inositol-1,4,5-triphosphateIns(1,4,5)P3Myo-Inositol-1,3,4,6-tetraphosphateIns(1,3,4,6)P4Myo-Inositol-1,3,4,5-tetraphosphateIns(1,3,4,5)P4Myo-Inositol-1,4,5,6-tetra
15、phosphateIns(1,4,5,6)P4Myo-Inositol-1,2,3,4,6-pentaphosphateIns(1,2,3,4,6)P5Myo-Inositol-1,3,4,5,6-pentaphosphateIns(1,3,4,5,6)P5Myo-Inositol-1,2,3,4,5-pentaphosphateIns(1,2,3,4,5)P5Myo-Inositol-1,2,4,5,6-pentaphosphateIns(1,2,4,5,6)P5Myo-Inositol-1,2,3,4,5,6-hexaphosphateIns(1,2,3,4,5,6)P6 (Phytic
16、acid)GlycogenGlycogenin8-oxoguanineA common DNA lesions Toolkit IO6-methylguanineUracilThymine glycol1, N6-ethenoadenine3-methyladenineCyclobutane pyrimidine dimersPhotoadductRiboseGlucuronateArabinoseFructoseGlucoseGalactoseMannoseFucoseSialic AcidInositolD-AbequoseL-RhamnoseA carbohydrate toolkitPGH2TXA2TXB2Bioactive lipids - ProstanoidsPGD2PGJ2PGE2PGA2PGB2PGF2PGF-MPGI26-keto-PGF1 Bioactive lipids - Leukotrienes5-HETELTA4LTB4LTC4LTD4LTE420-OH- LTE4LXA4LTB4LTF4LXALXBBioactive lipidsArachidonateCeramideSphingosine-1-phosphatePAFPhosphatidic acidAnandamide 2-Arachidonoylglycerol
