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1、Dr Martin SmithConsultant Paediatric NeurologistBirmingham Childrens HospitalDyskinetic Cerebral PalsyGreater Manchester Cerebral Palsy Network Meeting 7th November 2021ChoreaAthetosisDystoniaIntermittent; irregular Sustained posturesUnsustained; flowingAbnormal (usually high) muscle toneWeaknessImp
2、aired motor controlDystoniaInvoluntary sustained or intermittent muscle contractions cause twisting and repetitive movements, and/or abnormal posturesInserted postures and movementsChoreaGreek, khoreia, meaning danceInvoluntary, random (appearing), quick jerking movementsAbrupt, non-repetitive and a
3、rrthymicVariable frequency and intensityAthetosisDescribed by Hammond (1871) as “an inability to retain the fingers and toes in any position they might be placed, and by their continual motionHyperkinetic movement disorder characterised by involuntary writhing movements of the distal extremities and
4、 peri-oral musclesSome consider athetosis as a variant of dystoniaSymmetrical high signal in ventro-lateral thalamus and putamen following acute near total hypoxic-ischaemic injury in term infantTreatmentsOrthosis e.g. lycra, second skin etcMedication for dystonia e.g. Trihexiphenidyl, Clonidine, L-
5、DopaMedication for chorea e.g. Levitarecetam, Valproate, TetrabenzineIntra-thecal BaclofenDeep brain stimulationStem cells ?Thanks to Birmingham colleagues past and presentDr Hardev PallDr Manju KurianDr Stuart GreenThanks to children and families for allowing me to use videos for teaching and education
