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1、Apoptosis and Cell Cycle PCR Array 细胞凋亡与细胞周期基因芯片凋亡PCR芯片细胞凋亡PCR芯片 384HT细胞周期PCR芯片Apoptosis PCR Array凋亡PCR芯片Catalog No. PAHS-012A（人）Catalog No. PAMM-012A（小鼠）Catalog No. PARN-012A（大鼠）The Apoptosis RT Profiler PCR Array profiles the expression of 84 key genes involved in apoptosis, or programmed cell dea
2、th. The array includes the TNF ligands and their receptors; members of the bcl-2, caspase, IAP, TRAF, CARD, death domain, death effector domain, and CIDE families; as well as genes involved in the p53 and ATM pathways. Using real-time PCR, you can easily and reliably analyze expression of a focused
3、panel of genes related to apoptosis with this array.细胞凋亡RT Profiler PCR Array可以同时测定84个与凋亡即细胞程序性死亡有关的关键基因。其中包括TNF配基及其受体，Bcl-2家族成员、caspase、IAP、TRAF、CARD、死亡结构域、死亡效应结构域和CIDE家族，同时还包括p53和ATM信号通路相关的基因。利用实时定量PCR，你可以方便并且可信地对与凋亡相关的基因进行同时检测。TNF Ligand Family: CD40LG (TNFSF5), FASLG (TNFSF6), LTA, TNF, TNFSF10,
4、 TNFSF7, TNFSF8. TNF Receptor Family: CD40 (TNFRSF5), FAS (TNFRSF6), LTBR, TNFRSF10A, TNFRSF10B, TNFRSF11B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF7, TNFRSF9. Bcl-2 Family: BAD, BAG1, BAG3, BAG4, BAK1, BAX, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L11, BCL2L2, BCLAF1, BID, BIK, BNIP1, BNIP2, BNIP3,
5、 BNIP3L, HRK, MCL1. Caspase Family: CASP1, CASP10, CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP9. IAP Family: BIRC1, BIRC2, BIRC3, BIRC4, BIRC6, BIRC8. TRAF Family: TRAF2, TRAF3, TRAF4. CARD Family: APAF1, BCL10, BIRC2, BIRC3, CARD4, CARD6, CARD8, CASP1, CASP2, CASP4, CASP5, CASP9,
6、CRADD, NOL3, PYCARD, RIPK2. Death Domain Family: CRADD, DAPK1, FADD, FAS (TNFRSF6), TNFRSF10A, TNFRSF10B, TNFRSF11B, TNFRSF1A, TNFRSF21, TNFRSF25, TRADD. Death Effector Domain Family: CASP8, CASP10, CFLAR, FADD. CIDE Domain Family: CIDEA, CIDEB, DFFA. p53 and DNA Damage Response: ABL1, AKT1, APAF1,
7、BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, GADD45A, TP53, TP53BP2, TP73. Anti-apoptosis: AKT1, BAG1, BAG3, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L2, BFAR, BIRC1, BIRC2, BIRC3, BIRC4, BIRC6, BIRC8, BNIP1, BNIP2, BNIP3, BRAF, CASP2, CFLAR, FAS (TNFRSF6), IGF1R, MCL1, TNF, TNFRSF7. TNF配基家族;T
8、NF受体家族；Bcl-2家族；Caspase 家族；IAP家族；TRAF家族；CARD家族；死亡结构域家族；死亡效应结构域家族；CIDE结构域；P53和DNA损伤反应有关基因；抗凋亡基因Apoptosis PCR Array 384HT细胞凋亡PCR芯片 384HTCatalog No. PAHS-3012A（人）The Human Apoptosis RT Profiler PCR Array 384HT profiles the expression of 370 key genes involved in apoptosis, or programmed cell death. The
9、array includes the TNF ligands and their receptors; members of the bcl-2 family, BIRC (baculoviral IAP repeat) domain proteins, CARD domain (caspase recruitment domain) proteins, death domain proteins, TRAF (TNF receptor-associated factor) domain proteins and caspases. These 370 genes are also group
10、ed by their functional contribution to apoptosis, either anti-apoptotic regulation or the induction of apoptosis by death domain receptors, DNA damage, oxidative stress, or extracellular and intracellular signals. Using real-time PCR, you can easily and reliably analyze the expression of a focused p
11、anel of genes related to apoptosis with this array.细胞凋亡RT Profiler PCR Array384HT可以同时测定370个与细胞凋亡、程序性死亡相关的关键基因的表达谱。其中包括TNF配体及其受体、bcl-2家族成员、BIRC（baculoviral）结构域蛋白、CARD（caspase recruitment domain）结构域蛋白、死亡结构域蛋白、TRAF（TNF receptor-associated facor）结构域蛋白和caspases。这370个基因涉及以下几种功能：凋亡、通过死亡结构域受体诱导凋亡或抗凋亡、DNA损伤、
12、氧化应激以及细胞内和细胞外信号转导。利用实时定量PCR，你可以方便并且可信地对与凋亡相关的基因进行同时检测。TNF Domain Proteins: EDA, FASLG, LTA, LTB, TNF, TNFSF10, TNFSF14, TNFSF15, TNFSF8.TNFR Domain Proteins: CD27, CD40, FAS, LTBR, NGFR, TNFRSF10A, TNFRSF10B, TNFRSF10D, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF6B, TNFRSF8, T
13、NFRSF9.BCL2 and BAG Domain Proteins: BAG1, BAG3, BAG4, BAX, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L13, BCL2L2, MCL1.BIR Domain Proteins: BIRC2, BIRC3, BIRC4, BIRC5, BIRC6, BIRC7, BIRC8, NAIP (BIRC1).CARD Domain Proteins: APAF1, BCL10, BIRC2, BIRC3, CARD10, CARD11, CARD14, CARD6, CARD8, CARD9, CASP1, CA
14、SP2, CASP4, CASP5, CASP9, CRADD, ICEBERG, INCA, NLRP1 (NALP1), NOD1, NOD2, NOL3, PYCARD, RFWD2 (COP1), RIPK2.DEATH Domain Proteins: CRADD, DAPK1, EDAR, FADD, LRDD, MALT1, NFKB1, NFKB2, NGFR, RIPK1, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF21, TNFRSF25, TRADD.TRAF Domain Proteins: TRAF2, TRAF3, TRAF5, T
15、RAF7.Caspases and Regulators: Caspases: CASP1, CASP10, CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP9, CFLAR, CRADD, ICEBERG, INCA, MALT1, PYCARD, RFWD2 (COP1). Caspase activators: AIFM3, APAF1, BAX, BBC3, BCL2L10, BCL2L13, CARD8, CASP1, CASP8AP2, CASP9, COL4A3, CYCS, DIABLO, EIF2AK3
16、, F2, F2R, FOXL2, HIP1, HSPE1, IFNB1, IFT57, LCK, MAP3K5, MOAP1, MTCH1, MYC, NLRC4, NLRP1, NLRP12, NLRP2, NLRP3, NOD1, PMAIP1, PYCARD, STAT1, TNFRSF10A, TNFRSF10B, TNFSF15, TP53, TPD52L1, VCP. Caspase inhibitors: BIRC4, BIRC5, CD27, DHCR24, HBXIP, IFI6, SFN, TNFAIP8, TNFSF14, TRIAP1. Anti-Apoptosis Genes: Positive regulation of anti-apoptosis: BCL2L1, BRE, CD28, ERC1, MAPK8IP2, OPA1, PRKAA1, RASA1
