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1、EE途人林ELLble1.SingleAgentsVersusPlatinum/ModernAgentCombinationMedlanSurvvalmo1-VYearSurviyESouthwestOncologyGroupfz4321“Vinoretbinefctplatn258356Ciplatn习520HooslerOncologyGroup(m=5521“GematabinecisplatnE9ECiplatn10728Europeanfnz4la“Paditaxeckplatn25a1NACiplatn0125NACancerandLeukemisGioup多训孙f扬的河Padta
2、xecarboplatn3088EPadtaxel1757EGreekCooperativeGroup(nz319“DocetaxeasplatnE1054Docetaxel2280一SwedlshLungCancerStudyGroupfn=2751“Gemcitabinelcarboplatn。30104carboplatn1290ETable2-SelectedTrialsComparingvariousPlatinum-BasedRegimensinFirst-LineTherapyforNSCLCxazeeEcoaEnsoargoseltane仁cocporaeyeutlnation
3、alabswocasoeIn5sEEEpcvepceacvepcbvavcvcvepcpEpcv0vsEzvsEpceEaeothsoeanecag:looevssaao2vs:1seoee_pcPcbwesrE2-3295Ev13ECG0nanceeeapyiyEFigure1.TreatmentparadigmfortheuseofnovelbiologicagentsWithchemotherapyinadvancednon-Smalcellungcancer(NSCLOLeeynnueneESignaltransductionGrowthfactorsInvasionCelleycle
4、controlAngi2TumourRProliferatingvasculatureyLL11comtumourcellsBE东E仪M应应不团一孔受体(EGFR酪氨酸激酶抑制E如吉非替尼(Ge肋mbIressa,易瑜沙);埃罗替尼(Erlotinib,Tarceva);抗EGFR的单抗,如西妥昔单抗(Cetuximab,0仁认抗HER_蘑嘉攫Herceptin);LBcr-Abl酪氨酸激酶抑制剂,如伊马替尼(Imatinib);E人肖(Avastin);孔受体抑制剂,如Bevacizumab相,春办1E抗CD20的单抗,如利妥昔单抗(Rituximab);IGFR一1激酶抑制剂如NVPAEW
5、541;他如Aumra激酉每抑制剂团汀(HDACS)抑制剂等。1E仪口T巳1人孙-万二lecteclTrcl人士人一PeraPi冲=inm“INLiCm一三n二-C11LCC二口=fitinib人B-EGSF人baemizxc2EZzoooCEMACPharrnaceurtical=SvvzotSCGSlaxcosrnithiclime2Va=cualmrr心巴vaacizmi心行=CSAZQ周口=-氏5interacticsLcCmafarmibScorafeniborBAY43-9ooS2TiPifarmib人aicea心口心i人naicstattnm一=vacizurn心巳CyciooxyoemasetnPibbitcrc【ctheepidermalgrowthfactortransforminggrowthfactor-(.国
