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1、5c，蠹D薹B蜂月怡COPD患者运动的心肺反应首都医科大学附属北京友谊医院徐秋芬yz14&12%&10%飙_卜8龌84砺420COPD患病率4-20%40加东人中108Xb70%47%1WMOnpotGoolsumetecepeerionsrdcvoyencpvapyaweecsconphersveappssh001.2DenyengMaaJesclug0s206824PomgNataltpJfesgyCWCoeltdipoi67560tEonpesnLingWhieeeak3004.5Cest/Ja吴EnonkcCsoaStiinenChereDbanclieDsseseCOPIusrale
2、nLungfoudstoniaD字叨秉Anatiy座-恩墨l伪丁口苏|刀君鼎芝ERennadSelalEurRespirJ2002i20:789OgaTetalAnJhesprClCaneMed2003i167:544ExerciseCapacityDeteriorationinPatientsWith河COPD-LongitudinalEvaluationOver5YearsToruOgaetalCHEST2005;125.62-69,榛霆戛雳差P*137名男性中重度COPD“FEV145.9土15.4?%predicted“每6个月,进行心肺运动试验和肺功能测定nncoierhpvitsp
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6、ru0gaetalCHEST2005;128:62-69ChangeinpeakVoztmmivugyean)ChangeinpeakVOztnlainkgyeansensaeaan林根西ChangeinFEVi(ipredictedlyeanChangeinpeakNenineanbeeweenechengJseladoel。ddongenpaskWosanddiedUandbCofpbecanelnpostmonciodthiorFpvuInpaskVenghe月口paienesitP运动受限的原因是多方面的肺功能障碍“阻堀?“限制?“弥散?骨骸肌功能障碍肺动脉高压营养不艮或肥胖心脏去适应
7、(deconditioning)心理障碍A字叨表Pn;C0PD患者运动高峰时的通气反应徐秋芬王浩彦肖琛丁涂菊杜静张玲.中华医s8志,2008.88:2108-1140名男性COPD患者,稳定期,64.5士7.3岁正常对照组为健康男性15名,61.1士8.1岁基础肺功能血气测定.静态,运动高峰心肺运动试验。刁率自行干,疳状自限EqCOa=VeVCO。VoVr=(PaCOa-PeCO。)/PacOal-(VDvalve/V)命y导古秀,x二噬之COPD趸二且与正常对照组生理参数和肺功能比较河组别例数“年龄“身高体重FEV1占预计值%FEVHFVCRV/TLC伟)cm(ko)(9)(对煌组1561.
8、1丶81162.6土108669土10.7T11.6士10.0785土35313土6.1COPD“40625士791684士54“714土11.0630士26576丶113“486士12201.9011.9811.335-8.051-80444540p倩0.0600.6400.189000100010001组别“例数DLco“Dico直顷计倩5一DLcoVADLcoVA吊预订值%mlminmmHg%minmmhHg%对照组“1515.8土4378.6土12.13.9土0.5100.0土10.6COPD“40“15.1土4.5“77.2土20.73.6土0.996.1士24.9t值-0.430-0.185-1.442-0.698p值0.6690.8540.1660.491c，D。牵OPD组与E常对照组运动高峰时参数比较组别“例数HRmaxVOamax“VCOamaxEqCO。beatsyminmVkglminmVkg/min对照组15“140.13土19.0618.86土4.25“25.28土7.1228.50土2.56COPD“40“128.70土20.1314.83土3.64“19.38土5.88“33.01土5.13值7896工82047“2862】3172p值0.080.0030.0070.003
