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1、Evolution of Resistance to Antibiotics in Bacteria,Presented by Jana Boozer Katelin Erwin Ashley Gregory Sara Thompson,HUMANS & NATURE:,What is antibiotic resistance?,Antibiotic resistance occurs when an antibiotic has lost its ability to effectively control or kill bacterial growth; in other words,
2、 the bacteria are “resistant“ and continue to multiply in the presence of therapeutic levels of an antibiotic.,Why do bacteria become resistant to antibiotics?,When antibiotics are used to kill the bacterial microorganisms, a few microorganisms are able to still survive, because microbes are always
3、mutating, eventually leading to a mutation protecting itself against the antibiotic,Antibiotics that are used correctly overwhelm the harmful bacteria Overuse of antibiotics or unnecessary use creates a selective environment Resistant bacteria has better fitness in this context Resistant strains sur
4、vive and multiply. After reproducing, the resistant bacteria move to another host.,How humans have created the upsurge of bacterial diseases:,International travelInadequate sanitation“antibiotic paradox”,How do bacteria become resistant?,Bacteria can gain resistance over time through:Acquired resist
5、anceVertical gene transferHorizontal gene transfer,Acquired Resistance,Mechanisms are developed by bacteria in order to acquire resistance Either modification of existing genetic material or acquisition of new genetic material from another source. Development of resistance through spontaneous mutati
6、on is called primary resistance. Errors in DNA synthesis during replication Occasional failures in the DNA repair systems,Vertical Gene Transfer,Resistant genes are developedGenes directly transferred to progeny during DNA replicationThis is directly related to Darwins theory of evolution.,Horizonta
7、l Gene Transfer (HGT),“lateral gene transfer” Genetic material is contained in small packets of DNA. Packets can be transferred between individual bacteria of the same species or different species.,3 Mechanisms of HGT,TransductionTransformation Penicillin-resistant gonorrhea Conjugation In 1968, 12,
8、500 people in Guatemala died of Shigella diarrhea epidemic.,Spread of Resistant Bacteria,Rapid growth of bacteria Small size Simple internal structure Multiply rapidly New generation in as little as 20 minutes,Strategies to delay widespread antibiotic resistance:,Dont use antibiotics to treat viruse
9、s or viral infections. Avoid mild doses of antibiotics over a long period of time. When treating a bacterial infection with antibiotics, take all the pills. Use a combination of drugs to treat bacterial infections Reduce/eliminate “preventive” use of antibiotics on livestock and crops.,Evolutionary
10、theory:,Given time, heredity, and variation, any living organism will evolve when a selective pressure is introduced,Benefit/Cost,Benefit In presence of antibiotics, being resistant benefits bacteria. Cost Resistant genotypes are less fit than sensitive counterparts in the absence of antibiotics,Can
11、 bacteria lose their antibiotic resistance?,Antibiotic resistance traits can be lost Occurs more slowly Selective pressure is removed Bacterial population can potentially revert to a population of bacteria that responds to antibiotics.,With more research, education of the public, and well thought ou
12、t regulations, the problems can be solved. Several strategies are currently used to find new antibacterial compounds and new strategies are in development and trial.,Sources,http:/evolution.berkeley.edu/evosite/relevance/IA1antibiotics.shtml http:/www.fda.gov/Fdac/features/795_antibio.html http:/www.pbs.org/wgbh/evolution/library/10/4/l_104_03.html http:/www.scq.ubc.ca/attack-of-the-superbugs-antibiotic-resistance/ http:/ http:/www.tufts.edu/med/apua/Q&A/Q&A_AR.html,
