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,OSAS 与动脉粥样硬化,OSAS相关动脉粥样硬化,氧化应激与慢性炎症学说 血管内皮损伤 脂蛋白的氧化修饰 胰岛素抵抗,Evidence of early atherosclerotic development,动脉粥样硬化与炎症,炎症反应在AS的发病机制中起着重要的作用。C-反应蛋是应答于炎症白由肝脏合成的细胞因子,也是发生糖尿病和心血管疾病危险预测因子。,Before,nCPAP,nCPAP,Before,CRP,IL-6,P0.0001,P0.0001,mg/dL,pg/ml,0.0,1.0,2.0,3.0,0.0,0.1,0.2,0.3,0.4,0.5,0.6,Activation of inflammatory pathways in OSA,Serum levels,Spontaneous IL-6 production by monocytes. 24h culture,Yokoe et al. Circulation 2003;107:1129-34,