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1、,非侵袭性真菌性鼻窦炎许雄辉 方炜烨,目录,病因,aspergillus、penicillium、monilia,Click To Edit Title Style,Invasive,Non-invasive,Sinus fungal ball,Sequestration of fungal elements within a sinus without invasion or granulomatous changes grow while evading host immune system (no invasion) Aspergillus most common species Max
2、illary sinus most often involved (70-80% of cases),DiagnosisCT Scan: Single sinus in 59-94% of cases (maxillary) Complete or subtotal opacification of sinus Bony sclerosis; destruction is rare (3.6-17% of cases) Biopsy = fungal elements,Treatment Complete surgical removal of fungal ball Irrigation o
3、f involved sinuses Antifungal therapy Only if patient is high risk for invasive disease (very rare) Severely immunocompromised Continued recurrence of disease despite proper medical/surgical management Consider topical antifungal irrigation first and then systemic therapy if no improvement,Allergic
4、Fungal Sinusitis,Fungal colonization resulting in allergic inflammation without invasion Diagnostic Criteria Eosinophlic mucin(组织病理学 黏蛋白) Nasal polyposis（鼻息肉或哮喘） Radiographic findings（典型影像学） Allergy to fungi（对霉菌过敏）,Treatment Surgical Remove all mucin Provide permanent drainage and ventilation of aff
5、ected sinuses(鼻窦开放) Systemic +/- topical steroids（糖皮质激素）- Immunotherapy,SOUCE,杨秀敏, 刘铭. 100 例真菌性鼻窦炎的病原菌分析J. 耳鼻咽喉: 头颈外科, 2000, 7(1): 9-13. 李永奇. 真菌性鼻窦炎的诊疗进展J. 国外医学: 耳鼻咽喉科学分册, 2003, 27(3): 162-166. 薛康. 鼻内镜手术治疗非侵袭性真菌性鼻窦炎 42 例J. 临床耳鼻咽喉头颈外科杂志, 2008, 22(17): 804-805. 张书文, 孙士铭. 真菌性鼻窦炎的 CT 与临床诊断J. 临床放射学杂志, 20
6、02, 21(10): 778-780. GB/T 7714刘铭, 周兵, 刘华超, 等. 变应性真菌性鼻窦炎J. 中华耳鼻咽喉科杂志, 2002, 37(3): 169-172. 周兵, 刘铭, 韩德民, 等. 变应性真菌性鼻窦炎 CT 影像特征J. 中华耳鼻咽喉头颈外科杂志, 2006, 41(7): 493-496. 钱进, 孙建军, 郭红光, 等. CT 检查在真菌性鼻窦炎术前诊断的意义J. 中国耳鼻咽喉头颈外科, 2005, 11(5): 313-315. 常京文, 王晓珊, 李声凯. 鼻内镜手术治疗非侵袭性真菌性鼻窦炎J. 临床耳鼻咽喉头颈外科杂志, 2008 (20). 李源, 顾之燕. 变应性真菌性鼻窦炎J. 见: 顾之燕, 韩志刚, 刘志连. 耳鼻咽喉科变应性和免疫性疾病. 天津: 天津科学技术出版社, 1999, 53258. 李鹏, 刘贤, 李源, 等. 咪康唑灌注在非侵袭性真菌性鼻窦炎手术后的应用J. 中国内镜杂志, 2005, 11(9): 932-934.,THANK YOU,
