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1、葡萄熟了“纳帕溪谷”地产项目一期业主入住仪式庆典策划案PPT培训课件汽车频道沃生活自驾游方案钱湖牌大闸蟹营销推广策划方案秦皇凤城庭院楼盘项目开盘活动策划方案禽流感教学课件现代脂质三联治疗葡萄熟了“纳帕溪谷”地产项目一期业主入住仪式庆典策划案PPT培训课件汽车频道沃生活自驾游方案钱湖牌大闸蟹营销推广策划方案秦皇凤城庭院楼盘项目开盘活动策划方案禽流感教学课件IntroductionPart I葡萄熟了“纳帕溪谷”地产项目一期业主入住仪式庆典策划案PPT培训课件汽车频道沃生活自驾游方案钱湖牌大闸蟹营销推广策划方案秦皇凤城庭院楼盘项目开盘活动策划方案禽流感教学课件Efficacy - The Powe
2、r to Reach TargetKey Factor:Key Factor: + +Differentiators:Differentiators:LDL ReductionTGHDLLDL/HDL RatioThe Lipid Triad 葡萄熟了“纳帕溪谷”地产项目一期业主入住仪式庆典策划案PPT培训课件汽车频道沃生活自驾游方案钱湖牌大闸蟹营销推广策划方案秦皇凤城庭院楼盘项目开盘活动策划方案禽流感教学课件The LDL/HDL Ratio - Our Strength, Our Story!Clear positioning for LipobayA new perception of
3、efficacyDifferentiation to AtorvastatinFit with our product profile葡萄熟了“纳帕溪谷”地产项目一期业主入住仪式庆典策划案PPT培训课件汽车频道沃生活自驾游方案钱湖牌大闸蟹营销推广策划方案秦皇凤城庭院楼盘项目开盘活动策划方案禽流感教学课件LDLHDLAdditional risk factor, especially in diabeticsThe Lipid Triad - OverviewTGThe Lipid TriadThe Ratio葡萄熟了“纳帕溪谷”地产项目一期业主入住仪式庆典策划案PPT培训课件汽车频道沃生活自驾
4、游方案钱湖牌大闸蟹营销推广策划方案秦皇凤城庭院楼盘项目开盘活动策划方案禽流感教学课件The Lipid Triad and Strategic Rationale Part II葡萄熟了“纳帕溪谷”地产项目一期业主入住仪式庆典策划案PPT培训课件汽车频道沃生活自驾游方案钱湖牌大闸蟹营销推广策划方案秦皇凤城庭院楼盘项目开盘活动策划方案禽流感教学课件 No scientific evidence Evidence contradicting this statement A marketing hypothesis to build their LDL story Creating the per
5、ception of the statin with the strongest efficacy葡萄熟了“纳帕溪谷”地产项目一期业主入住仪式庆典策划案PPT培训课件汽车频道沃生活自驾游方案钱湖牌大闸蟹营销推广策划方案秦皇凤城庭院楼盘项目开盘活动策划方案禽流感教学课件Its logicalIts measurableIts practicableThe Lipid Triad - The GPs Perspective葡萄熟了“纳帕溪谷”地产项目一期业主入住仪式庆典策划案PPT培训课件汽车频道沃生活自驾游方案钱湖牌大闸蟹营销推广策划方案秦皇凤城庭院楼盘项目开盘活动策划方案禽流感教学课件葡萄熟了
6、“纳帕溪谷”地产项目一期业主入住仪式庆典策划案PPT培训课件汽车频道沃生活自驾游方案钱湖牌大闸蟹营销推广策划方案秦皇凤城庭院楼盘项目开盘活动策划方案禽流感教学课件Supporting Data from Landmark StudiesPart III葡萄熟了“纳帕溪谷”地产项目一期业主入住仪式庆典策划案PPT培训课件汽车频道沃生活自驾游方案钱湖牌大闸蟹营销推广策划方案秦皇凤城庭院楼盘项目开盘活动策划方案禽流感教学课件121086420% MortalityPlacebo Q1 Q2 Q3 Q4 (low HDL-increase) (high HDL-increase)4S - StudyC
7、AD Mortality per Quartiles of Increases in HDL-CholesterolKJEKSHUS J 341:41006-31-4-35-30-25-20-15-10-50510Cholesterol LDL-C HDL-C TriglyceridesPercent change compared to placebo at 1 yearSecondary Prevention in 2531 men with low HDL-C 79: 8 - 15.HDL - C mg / dl 65 55 45 35LDL - Cholesterol mg / dlL
8、DL - Cholesterol mg / dl121086420 100 130 160 190葡萄熟了“纳帕溪谷”地产项目一期业主入住仪式庆典策划案PPT培训课件汽车频道沃生活自驾游方案钱湖牌大闸蟹营销推广策划方案秦皇凤城庭院楼盘项目开盘活动策划方案禽流感教学课件00.511.522.53Framingham Heart StudyCAD risk as a function of LDL-C and HDL-Cin men (50 to 70 y)CASTELLI WP. Am J Cardiol 1998; 82:60-65220 160 10085654525HDL-Choleste
9、rol (mg/dl)LDL Cholesterol (mg/dL)葡萄熟了“纳帕溪谷”地产项目一期业主入住仪式庆典策划案PPT培训课件汽车频道沃生活自驾游方案钱湖牌大闸蟹营销推广策划方案秦皇凤城庭院楼盘项目开盘活动策划方案禽流感教学课件0246810121416LDL5HDL=1.08 HDL5Incidence of cardiac events (per 1000 person-years)GemfibrozilPlaceboLDL-C Tertiles (mmol/L)HDL-C Tertiles (mmol/L)LDL-C/HDL-C Tertiles244632 3634 4522
10、 3938 5318 29Incidence for cardiac events vs lipid parameterHelsinki Heart StudyMANNINEN V, Leena T, Koskinen P et al. Circulation 1992; 85: 37-45葡萄熟了“纳帕溪谷”地产项目一期业主入住仪式庆典策划案PPT培训课件汽车频道沃生活自驾游方案钱湖牌大闸蟹营销推广策划方案秦皇凤城庭院楼盘项目开盘活动策划方案禽流感教学课件AFCAPS/TEXCAPS Apo B/A1 Tertiles LDL-C/HDL-C Tertiles 1.6 1.4 1.210.8
11、 0.6 0.4 0.2 0 1.6 1.4 1.210.8 0.6 0.4 0.2 0 Event Rate per 100 Patient-Years of RiskEvent Rate per 100 Patient-Years of Risk 0.88890.8898- 1.02051.0252 3.77423.7744- 4.40964.4101GOTTO A et al. Circulation 2000; 101: 477-484LDL/HDL Ratio as Therapeutic SuccessPlaceboStatin 葡萄熟了“纳帕溪谷”地产项目一期业主入住仪式庆典策划
12、案PPT培训课件汽车频道沃生活自驾游方案钱湖牌大闸蟹营销推广策划方案秦皇凤城庭院楼盘项目开盘活动策划方案禽流感教学课件24116312450501001502002503005LDL / HDL - RatioTriglycerides = 200 mg/dlCAD cases per 1,000 subjects in 6 yearsASSMANN G and SCHULTE H; Am J Cardiol 1992; 70: 733-737Incidence of CAD vs LDL/HDL ratio by TG level (n = 4559)PROCAM Heart Study 葡
13、萄熟了“纳帕溪谷”地产项目一期业主入住仪式庆典策划案PPT培训课件汽车频道沃生活自驾游方案钱湖牌大闸蟹营销推广策划方案秦皇凤城庭院楼盘项目开盘活动策划方案禽流感教学课件050100150200250300567 LDL/HDL ratioCHD Incidence/1000 in 6 yearsCHD risk according to LDL/HDL ratio at baselineASSMANN G; Lipid Metabolism Disorders and CHD; MMV Medizin Verlag, 1993: 435High CHD riskMediumMedium CHD
14、 riskCHD riskLow Low CHD riskCHD risk3-55High CHD riskMedium CHD riskLow CHD risk8%60%32%90%9%1%3-550% HDL increaseData on file0.4 mg responder rate at 8 weeks6.510.317.98.2葡萄熟了“纳帕溪谷”地产项目一期业主入住仪式庆典策划案PPT培训课件汽车频道沃生活自驾游方案钱湖牌大闸蟹营销推广策划方案秦皇凤城庭院楼盘项目开盘活动策划方案禽流感教学课件9080706050403020100 1023.39.381.465.155.8
15、20 30 40 50TG responder rates for 0.4 mg TG % reduction rates from baseline 300 mg/dl at 8 weeks ( n = 43)Cumulative % of respondentsData on file葡萄熟了“纳帕溪谷”地产项目一期业主入住仪式庆典策划案PPT培训课件汽车频道沃生活自驾游方案钱湖牌大闸蟹营销推广策划方案秦皇凤城庭院楼盘项目开盘活动策划方案禽流感教学课件Triglyceride mean % change from baseline after 8 weeks-20-100-30-405pl
16、acebo0.3mg0.4mgBaseline triglycerides250 mg/dl0.1mg0.2mg10- 35-25-155TG Reduction STEIN E et al. Atherosclerosis 1999; 144 (S 1): A 37葡萄熟了“纳帕溪谷”地产项目一期业主入住仪式庆典策划案PPT培训课件汽车频道沃生活自驾游方案钱湖牌大闸蟹营销推广策划方案秦皇凤城庭院楼盘项目开盘活动策划方案禽流感教学课件Apo B/Apo A1 (LS-Means % Changewith minimum 8 weeks treatment)-20,0-10,00,0-30,0-40,05Placebo- 35,0-25,0-15,05,0Apo B/ Apo A1 Cer
