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1、Molecular Biology 分子生物学Lecture 1 (6 Sep ,2011, Tue)Molecular BiologyProf. Yanchun Yan (闫艳春), Graduate School of Chinese Academy of Agricultural vRevised layout which presents the most current research even more clearly and concisely(最新、最清楚、最简洁的研究成果); vDirect analysis of the genome in terms of its co
2、ntent of genes;vOver 800 full colour graphics to illustrate important concepts(用 图图片证证明重要概念); v Overview figures that summarize large amounts of work; vFree access to all illustrations on making learning and teaching from this book even easier. Preface to the 8th edition This edition of GENES marks
3、 the most significant reorganization for several editions. It is time to acknowledge that the power of direct analysis of the genome is making a significant difference to our approach. This is now recognized in the first part of GENES, which starts with the concept of the gene as a segment of DNA co
4、ding for protein and then proceeds directly to the characterization of the genome in terms of its content of genes. The rapidity of our advance in analyzing the genome has led to some confusion about means and ends. A genome is no more than the sum of the genes it contains, although the number and c
5、omplexity of these genes give us important insights into the nature of their connection into regulatory networks. The focus of this book, as its name suggests, therefore remains firmly on the gene. The thesis of GENES is that only by understanding the structure and function of the gene itself will w
6、e be able in turn to understand the operation of the genome as a whole. Although the emphasis has shifted to the characterization of eukaryotic genes, and therefore to their analysis by the direct techniques of molecular biology rather than the subtlety of genetics, the classical approach remains in
7、tellectually penetrating. It remains an aim of this book to integrate both approaches in the context of a unified approach to prokaryotes and eukaryotes. We consider the gene from all aspects: the basic forms that it takes, the numbers and relationships among genes in a genome, their packaging into
8、chromosomes, the process of gene expression from transcription through translation, the reproduction and safeguarding of the structure of the gene, and finally some aspects of the overall circuitry through which genotype determines phenotype. Almost two decades after the first edition of GENES, this
9、 latest edition is a celebration of the remarkable progress during that time, and, I hope, an indication of the future to come. Benjamin Lewin Cambridge, January 2004 Genes VII(,) ContentsPart 1 Genes 1 Genes are DNA 1 2 The interrupted gene 33 3 The content of the genome 51 4 Clusters and repeats 8
10、5Part 2 Proteins 5 Messenger RNA 113 6 Protein synthesis 135 7 Using the genetic code 167 8 Protein localization 195Part 3 Gene expression 9 Transcription 241 10 The operon 279 11 Regulatory circuits 301 12 Phage strategies 329Part 4 DNA 13 The replicon 353 14 DNA replication 387 15 Recombination an
11、d repair 419 16 Transposons 467 17 Retroviruses and retroposons 493 18 Rearrangement of DNA 513Part 5 The Nucleus 19 Chromosomes 545 20 Nucfeosomes 571 21 Promoters and enhancers 597 22 Activating transcription 631 23 Controlling chromatin structure 657 24 RNA splicing and processing 697 25 Catalyti
12、c RNA 731 26 Immune diversity 751Part 6 Cells27 Protein trafficking 787 28 Signal transduction 811 29 Cell cycle and growth regulation 843 30 Oncogenes and cancer 889 31 Gradients, cascades, and signaling Pathways 939 Glossary 981 Index 1003分子生物学常用参考书目1.分子遗传学( 孙乃恩)2.现代分子生物学（朱玉贤、李毅等)3.分子生物学 (Instant
13、Notes in Molecular Biology, 2nd Edition by P Turner）4.分子生物学(闫隆飞)5.Molecular Biology of the Cell (4th Edition by B Alberts)6.Molecular Cell Biology (4th Edition by H Lodish)7.Molecular Biology (2nd Edition by R Weaver) 8.Advanced Molecular Biology (by R Twyman) DNA ScienceA FIRST COURSE SECOND EDITION David A.Micklos Dolan DNA Learning Center Cold Spring Harbor Laboratory Greg A.Freyer College of Physicians Surgeons Columbia University With David A.Crotty Cold Spring Harbor Laboratory 2003 by Cold Spring Harbor Laboratory Pre
