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1、37112009M11 NEW CHEM ICAL MATERIALSVol1 37 No111# 1#8:SE$?Z9(9739)(2005CB623904)Te:i(1985- ),o,V3,VYF5yZb5FOZ孙庆兰1,2 张 华1* 张西正2 李瑞欣2 郭 勇2(11 天津工业大学理学院,天津300160;21 军事医学科学院卫生装备研究所,天津300161)K 1 血管支架材料在组织工程血管构建过程中起着非常重要的作用b近年来已合成与制备了许多新型血管支架材料,并对材料进行了相关方面处理b本文对天然生物材料a合成高分子可降解材料和复合材料等血管组织工程支架材料进行了综述b1oM 血
2、管组织工程,天然生物材料,高分子可降解材料Advances of vascular tissue engineering scaffold materialsSun Qinglan1, 2 Zhang Hua1 Zhang Xizheng2 Li Ruixin2 Guo Yong2( 11School of Science, Tianjin PolytechnicUniversity,Tianjin 300160;21Institute of Medical Equipment, Academy of Military Medical Sciences,Tianjin 300161)Abstr
3、act Vascular scaffold materials take avery important part in the construction of tissue engineering blood ves-sel. Recently, many novel scaffold materials, Which are treated in related aspects, have been synthesized and prepared,with the development of science and theexperimental technology of conti
4、nuous progress. A lot of vascular scaffold mater-ials were reviewed, such as natural biomaterials, synthetic and degradable polymer composites.Key words vascular tissue engineering, natural biomaterial, degradable polymer material3/,F?Z,75F9M?Zb5O5Fyd1T,%83,VF54B 94%,8AM,hb%Ms8,2i?Cf#CbMLV,5%VTBXO5F
5、bConklin11%),!%5b),?zb3qBm, 2?C%=%3zb1.2.2 非血管组织脱细胞基质d5F%l*/,b30M-4,%lTT5O14b,ylT/( Small IntestinalSubmucosa, SIS)3+sy0%*a39,se,v12-13bSISTB%,1s,c3y0,VCz3M,VTz5OPbHuynh12lT/%=4mm5,5=Vd8$,)bLtqB,VCzF?YqbM3,503lQb113 ?3N,K+M9?T5OM1L14-16bJockenhoevel 15t( 20Lg/ cc)e8,-l%,3mmO?zbJockenhoevelLV8BX5ObTu
6、rner16iBVHyaff-11,|=%1 106cells/ cm2Hyaff-11aO,24h,94%TOb20?VF)Hyaff-11O=%bTurnerLV,Hyaff-11V59=b2 s0Vs0yzVe,?z,F,K,)VF5O+7FK,K,K.F5OZJ.qv(D), 2006, 27(1): 124-129. 2 Thomas A C, Campbell G R, Campbell J H. Advances in vas-cular tissue engineeringJ. Cardiovasc Pathol, 2003, 12: 271-276. 3 S,v,RMY,.5
7、FOZJ.W:DSv, 2007, 41(3): 291-293. 4 Lee CH, Singla A, Lee Y. Biomedical applications of collagenJ. Int J Pharm, 2001, 221: 1-22. 5 Heimburg D, Zachariah S, Heschel I, et al. Human preadipo-cytes seeded on freeze-dried collagen scaffolds investigated invitro and in vivoJ. Biomaterials, 2001, 22: 429-
8、438. 6 BoccafoschiF, Habermehl J, VesentiniS, et al. Biologicalper-formances of collagen-based scaffolds for vascular tissue eng-ineeringJ. Biomaterials, 2005, 26: 7410-7417. 7 Weinberg C B, Bell E. A blood vessel model constructed fromcollagen and cultured vascular cellsJ. Science, 1986, 397-400. 8
9、 Ziegler T, Alexander R W, Nerem R M. An endothelial cell-smooth muscle cell co-culture model for use in the investigationof flow effects on vascular biologyJ. Annals of biomedicalen-gineering, 1995, 23: 216-225. 9 Lu QJ, Ganesan K, Simionescu DT, et al. Novel porous aorticelastin and collagen scaff
10、olds for tissue engineering J. Bioma-terials, 2004, 25: 5227-5237.10 Schaner P J, Martin N D, Tulenko T N, et al. Decellularizedvein as a protentialscaffold for vascular tissue engineeringJ.J. Vasc Surg, 2004, 40: 146-153.13 Lawler M R, Foster J H, Scott H W. Evaluation of canine in-testinal submuco
11、sa as a vascular substitute J. Am J Surg,122, 517-519 (1971).11 Conklin B S, Richter E R, Kreutziger K L, et al. Developmentand evaluation of a novel decellularized vascular xenograft J.Medical Engineering & Physics , 2002, 24(3): 173-183.12 Huynh T, Abraham G, Murray J, et al. Remodeling of an a-cellular collagen graft into a physiologically responsive neo
