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1、第31卷第7期 重庆大学学报 Vol. 31 No. 7null 2008年7月 Jour nal of Chongqing U niversity Jul. 2008 nullnull null c I | : 1000null582X( 2008) 07null0749null05 _ H ? 3 付志红1,赵俊丽1,罗null 聪2,谢品芳1( 1.重庆大学输配电装备及系统安全与新技术国家重点实验室,重庆 400030;2.重庆医科大学附属第一医院,重庆400016)l : 2008null03null16 :S E 1 S ( 50577071) ; , o u 3 L i ( KLV
2、Fnull2007null1)T e : ( 1966null) ,3 , i v q , p V , 1 V Y H 0 / , ( T el) 023null65111709;( Enullmail) fuzhihong cqu. edu. cnbK null 1 :针对药物靶向治疗中难以产生足够磁场强度和梯度的交流脉冲磁场问题,提出了采用双极性脉冲电流产生靶向引导磁场的新思路, 研制了一种适用于磁性药物聚焦和控制药物释放的靶向振荡磁场发生器,其主电路拓扑利用负载能量回馈, 减少电路损耗, 提高电流幅值和电流脉冲陡度,从而提高磁场强度和磁场强度变化率b该装置输出频率 0. 125 32 H
3、 z, 磁感应强度达1. 3 T,正弦磁场a单极性和双极性脉冲磁场的磁性微粒聚焦效果和振荡效果的对比实验, 证明双极性陡脉冲强磁场更适用于靶向治疗b双极性脉冲强磁场中磁性微粒聚集速度快, 聚焦效果好,振荡现象明显b1 o M :双极性脉冲电流;靶向治疗;引导磁场;振荡磁场;磁聚焦null null m s | : T M154 D S : ADevelopment of a targeting oscillating magnetic field generatorFU Zhinullhong 1, ZHAO Junnullli 1 , LUO Co ng 2 , XIE Pinnullfa
4、ng 1( 1. State Key Laboratory of Pow er T ransmission Equipm ent & System Security and New T echnology,Chongqing U niversity, Chongqing 400030, P. R. China; 2. The First Affiliated H ospital,Chongqing University of M edical Sciences, Chongqing 400016, P. R. China)Abstract: Focusing on the key equipm
5、 ent of targeting therapy, a novel method of adopting bipolar pulsecurrent to generate guiding magnetic field w as proposed. A high targeting oscillating magnetic fieldgenerator also w as developed. T hese innovations w ere used to contr ol the focus and to release m agneticdrugs to in an effort to
6、treat cancer. Based on the proposed tr ansm ission cir cuit, the load inductance ener gyfeedback cir cuit reduces loss, impr oves the current am plitude and strengthens the m agnetic field. Wor kfrequency of the designed equipm ent is 0. 125 H z to 32 H z, and the magnetic induction intensity r each
7、es1. 3 T. Experimental results show that, compared to sinusoidal and unipolar pulse magnetic fields, thebipolar steep pulse magnetic field is m ore suitable for magnetic drug focus and targeting therapy, and hasbetter perform ance of controlling the focus and release of magnetic particles.Key words:
8、 bipolar pulse current; targeting therapy; guiding magnetic field; oscillating magnetic field;magnetic focusingnull null H _ 0 d ( m agnetic targeting drugdelivery system , M TDDS) | 0 aH a 8 B , H T / ,P 0 u , i i d b, V 7 h M ? r bMT DDS r a + , S = D , H H , s A * E ; W ,H L 1I20U2T - U2sb (7)nul
9、l null 0 7 1 1 700 V E r 5( IGBT) , Us = 36 V, I 0= 50 A, 5 C 500 Fb1. 5null L TL H , 3 12 V 1 , 7 1 q 1 H z, C 2 F ( F 4 1 000 Fa450 V1 ) i (9 C = 500 F) , 7 1 5 P 1 700 Va100 A IGBT v bL o m 3 U , m i0 ( t) ,/ m u0 ( t), m 3V , i0(t)r 50 A, u0( t)r 620 Vbm 3null L o BELL | Model 7010 H N k L H , 5
10、0 A751第7期null null null null null null null null null null null null null null 付志红,等: 靶向振荡磁场发生器的研制H ,H 1. 3 T ; 30 A H , H 0. 757 54 Tb| H A k 5 b H M # , H T / H L n m 4b H T / , H L H j 5 C ,i O H v Z , H , r _ , H ? 3 bm 4 null H V 1. 6null Y B r T Y B ? 6 / W , ( , di/ dt= | uC/ L | ,uC null Us
11、, ? 6 / l 3 4 b| C= 500 F, Us = 36 V, L 1 = 0. 46 H, R1 =0. 8 #, f = 1 H z, T (1) ( 5) , 9 ? ? K s Y : I0 = 41. 6 A,uc1(t0 )= 1 230 Vb Y B , 9 , K v ? I N0 = UsR1( 1- e-R1L 1T4 ) = 15. 6 A 41. 6 Abnull null V T A , Y B V Y V 4 Z E 4 ? , , d !9 4 ,O ? o o , S M . b3 4 v , 6 a/ J ,L C ? ,h , v 4 H ? b2 null H o L 1 i
