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1、1 1. 2. 3. 4. / 5. 2 1. 3 4 5 http:/www.who.int/mediacentre/factsheets/fs211/en/ 6 5 65 60 2. 6 IPD 7 Position paper on pneumococcal vaccines (April 2012) wer8714 Pneumococcal Disease Types of infection non-invasive -otitis media -sinusitis - recurrent bronchitis invasive (IPD) -pneumonia -bacteremi
2、a -meningitis 8 IPD Common forms of pneumococcal disease 9 Introduction of pneumococcal vaccine PCV13 - A handbook for district and health facility staff , WHO,2013 - 2 -65 HIV 10 Position paper on pneumococcal vaccines (April 2012) wer8714 Pneumococcal Disease IPD 20%50% 11 WHO Influenza Position p
3、aper (November 2012) Hib Pneumococcal Disease Prevention and Treatment of Pneumococcal Disease 12 ICUVAP / / : PCV PPV : 13 ,2008 S. Pneumoniae Active Bacterial Core Surveillance (ABCs) Report, 2008 CDC ABC Surveillance report. http:/www.cdc.gov/abcs/survreports/spneu08.htm. Accessed Jan 2010. 0 5 1
4、0 15 20 25 30 35 40 45 112-45-1718-3435-4950-6465 Cases Per 100,000 Population 0 1 2 3 4 5 6 7 Deaths per 100,000 Population Age (years) Cases Deaths 3. 14 Influenza vaccines WHO3 3 2 1 20132014 4 3 1 4 15 http:/www.who.int/mediacentre/factsheets/fs211/en/ 2017 16 20142015 1881 19151945 194080 20119
5、2 17 USCDC Pink Book 13th Edition of Epidemiology and Prevention of Vaccine-Preventable Diseases (2015) 197714PPV 14 1983PPV 23 20007 PCV 7 2010PCV 13 1911 1940 1960 Pneumococcal Disease (PPV) -2 - 18 PCV - - Position paper on pneumococcal vaccines (April 2012) wer8714 Pneumococcal vaccines PCV7PCV1
6、3PPSV23 Serotypes included in PCV7 , PCV13 and PPSV23 4 6B 9V 14 18C 19F 23F 19 MMWR March 12, 2010 / 59(09);253-257 4 6B 9V 14 18C 19F 23F 1 3 5 7F 19A 2 8 9N 10A 11A 12F 15B 17F 20 22F 33F PCV7 PPSV23 4 6B 9V 14 18C 19F 23F 1 3 5 6A7F 19A PCV13 20 2013 21 , 2013, 36(4):225 22 , ADA2013 6 2 651 651
7、 51 23 2( 2013), 201410 24 22013201410 25 2012 2012542012.09.06 201210111130 26 60 60 27 60 2 20153 10 60 28 10 60 29 60 - - 23 Use of pneumococcal vaccines to reduce morbidity and mortality from bacterial pneumonia in an influenza pandemic 30 Use of pneumococcal polysaccharide vaccine for subjects
8、over 65 years of age during an inter-pandemic period.Technical Report Stockholm, January 2007 - - 31 0 50 100 150 200 250 19951996199719981999200020012002 Black White Conjugate vaccine licensed Ref: Flannery B et al. JAMA 2004 Vaccination eliminates inequalities 5 19952002 Invasive Pneumococcal Dise
9、ase in the USA, By Race, Children 90 http:/www.cdc.gov/vaccines/vpd-vac/pneumo/vacc-in-short.htm2015.06.19 PCV13 -5 -65 -6 PPSV23 -65 - 264 34 018, , 2017 Hib PCV13 IPV HPV PPV23 19, , 2017 35 1 1 10 1 HPV HPV PCV13 PPV23 Hib 19, , 2017 36 HIV CD4 (HIV) HPV HPV PCV13 PPV23 Hib 4./ 37 38 39 Learn fre
10、e or low-cost ways to be healthy 40 http:/www.cdc.gov/Features/BudgetForHealth/ Status in adult immunizations - - - 41 2014.08.06 1. 2. ( + ) 3.() 42 / / , 5. 43 The single best way to protect against the flu is to get vaccinated each year. 44 Key Facts About Seasonal Flu Vaccine 2010.07.15 http:/www.cdc.gov/flu/protect/keyfacts.htm 45 2 46 Thanks
