《差示扫描量热法在脂质体研究中的应用宁美英》由会员分享，可在线阅读，更多相关《差示扫描量热法在脂质体研究中的应用宁美英（6页珍藏版）》请在金锄头文库上搜索。
1、251(1- 2): 79- 84. 14 Gupta MK, Tseng YC, Goldman D, et al.Hydrogen bond-ing with adsorbent during storage governs drug dissolutionfrom solid-dispersion granules J. Pharm Res, 2002, 19(11):1663- 1672. 15 Andronis V, YoshiokaM, Zografi G. Effects of sorbedwateron the crystallization of indomethacin f
2、rom the amorphousstate J. J Pharm Sci,1997,86( 3): 346- 351. 16 Suzuki H, Sunada H. Some factors influencing the dissolu-tion of solid dispersions with nicotinamide and hydroxypro-pylmethylcellulose as combined carriers J . Chem PharmBull(Tokyo) , 1998, 46:1015- 1020.17 Guillaume F. Elaboration and
3、physical studyof an oxodipinesolid dispersion in orderto formulate tablets J. Drug DevInd Pharm, 1992, 18:811- 827.18 Zhou D, Zhang GG, Law D, et al. Physical stability ofamorphous pharmaceuticals: importance of configurationalthermodynamic quantities and molecular mobility J . JPharm Sci,2002,91(8)
4、 :1863- 1872.19 Six K,Verreck G,Peeters J, et al.Increasedphysical stabil-ity and improved dissolution properties of itraconazole,a class drug, by solid dispersions that combine fas-t and slow-dissolving polymers J . J Pharm Sci,2004,93( 1) : 124-131.UE8a1,R1,28,$2,n( 1.SDS/SxDSv93, 100073;2.SEg93S/
5、, 100081)K1: 差示扫描量热法(differential scanning calorimetry,DSC)是在差示热分析(DTA)基础上发展起来的一种热分析方法,本文对近年来有代表性的DSC在脂质体研究中应用的文献进行分析归纳,综述了DSC考察脂质体制备方法过程中结构的变化a药物与脂质体的相互作用a高分子聚合物对脂质体渗透性的影响a表面活性剂对脂质体柔性的影响等研究中的应用,为脂质体的深入研究提供有价值的参考资料b1oM: 差示扫描量热法; 脂质体ms|: R94 DSM: A cI|: 1001-0971(2005) 01-0056-06l: 2004-08-30:SE/ 973
6、09(G1999064)UE(differentialscanning calorimetry,DSC)Us(DTA)$?ZBsZEb$1,1M6,A1,YV$l()b(b)M,rsbM:VS,VSwL,DSCwL(9DSCsMm)bNsE,8BAWBb8sFH,1+Tm,B/VHiM(AM#M)Ms(phase separations),8F,VV3uv( domain structure),0aV4V?Y8TmM,V7Ms,9FYibDSCZE,YV4DSCwL8TmTma$T1/2a$H#MM9hMw8?3Mb2 DSC82.1 DSC8!ZEDSC8!ZE,BwZE8V#,6BQZE.
7、dZE!8bLi1B!8ZE2E,DSCZE8V,(vx1s)A|?(tBA)/4V,MmAUMM(12)b2tBA/,1AV1b,bA=c2M,=c1M1,T4U,VctBAM(tBA,c70%tBA),71icM(A,c80%)bytBA,0?3AMT;8s0sMTV?M8,V7YsV8dbbZhao 8YVDSC4,?/DPPC80DPPCTmY,bDPPC8Mm41eBV_U,36e)Bl7zbDSCs0i0.5 mol%H,DPPCTmhb,?iH,Tm_%M,iOUMzb$T1/2VUF,hl,8,V7,#Tm$HM,wi4M8+;iO4U48Bi1S=?z?0iT,4iBH,V7
8、0ilbWolka12DSC4E=-2-(N,N-=J)d1dodecy-l 2-(N,N-dimethylamino) propionate, DDAIP2DPPC8MT,H4i$H#58# Foreign Medical SciencesSection on Pharmacy 2005 Feb; 32( 1)YbDDAIPiV5 mol%950 mol%H,MM_uMOFz,MM9i4_uM,i4920%HhbMMMM$HDDAIP67,4PWoAMbDDAIPiv33.3%H,CBATm,4U?34-MsbT4U,DDAIPYVTuH99F_1V70bTrotta13BhF0KG,9BV48M1bTsY!KG4aKG8KG8s4bDSCNKG_vx(HPC)8W1bTAU, Tm( 49. 8 ? 0. 2) e$H( 7. 8 ?0.4)kcal#mol- 1,DDPPCTm41. 4e$H 8. 2 kcal#mol- 1,=a(DSPC)Tm54. 5e$H 10.2 kcal#mol- 1bNHPCcBt_s,_QTiBDPPC8,HPCMMhb8KGTm
