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1、Generic Name:Generic Name:Sibutramine hydrochlorideProduct Name:Product Name: Reductil/Ectiva 1aProduct name: Qu MeiGeneric Name: Sibutramine hydrochloride2a SibutramineFormula: C C17H H26Cl NCl N molecule Chemical structure3a Indications: obesity (obesity (肥胖症，多脂肥胖症，多脂) )！4a pharmacologypharmacolog
2、ySibutramine is a neurotransmitter(Sibutramine is a neurotransmitter(神神经递经递质质) reuptake ) reuptake 重吸收重吸收 inhibitor that inhibitor that reduces the reuptake of serotoninreduces the reuptake of serotonin 血清素血清素), norepinephrine), norepinephrine 去甲去甲肾肾上腺素上腺素 , and , and dopamine , thereby increasing t
3、he levels dopamine , thereby increasing the levels of these substances in synaptic clefts of these substances in synaptic clefts 突触突触间间隙隙 and helping enhance satietyand helping enhance satiety 饱满饱满感感 ; the serotonergic; the serotonergic 5-5-羟羟色胺能色胺能 action, action, in particular, is thought to influ
4、ence in particular, is thought to influence appetite. appetite. 5a contraindicationscontraindicationsSibutramine is contraindicated in:Sibutramine is contraindicated in:1 Psychiatric(1 Psychiatric(精神病学的精神病学的) conditions as bulimia nervosa) conditions as bulimia nervosa 神神经经性性贪贪食症食症 , anorexia, anore
5、xia 厌厌食症食症 , serious depression or , serious depression or preexisting maniapreexisting mania 狂躁症狂躁症 2 Patients below 18 years of age 2 Patients below 18 years of age 3 Concomitant3 Concomitant 伴行的，并伴行的，并发发的的 treatment with a MAO treatment with a MAO inhibitorinhibitor 单单胺氧化胺氧化酶酶抑制抑制剂剂 , antidepress
6、ant or other , antidepressant or other centrally active drugs, particularly other anoreticscentrally active drugs, particularly other anoretics 消瘦消瘦剂剂，减食欲，减食欲剂剂 4 Hypertension that is not sufficiently controlled 4 Hypertension that is not sufficiently controlled (caution in controlled hypertension)
7、(caution in controlled hypertension) 5 Existing pulmonary hypertension 5 Existing pulmonary hypertension 肺肺动动脉高血脉高血压压 6 Pregnant and lactating6 Pregnant and lactating 泌乳泌乳 women women 6a side effects!side effects!Frequently encountered side effects are: Frequently encountered side effects are: dry m
8、outh, paradoxically increased appetite, nausea(dry mouth, paradoxically increased appetite, nausea(恶恶心心), strange taste in the mouth, upset stomach, ), strange taste in the mouth, upset stomach, constipationconstipation 便秘便秘 , trouble sleeping, dizziness, , trouble sleeping, dizziness, drowsinessdro
9、wsiness 困倦困倦 , menstrual cramps/pain, headache, , menstrual cramps/pain, headache, flushingflushing 面面红红 , or joint/muscle pain., or joint/muscle pain.7aThe following side effects are infrequent but serious The following side effects are infrequent but serious and require immediate medical attention
10、: and require immediate medical attention: cardiac arrhythmiascardiac arrhythmias 心律不心律不齐齐 , paresthesia, paresthesia 感感觉觉异常异常 , , mental/mood changes (e.g., excitement, restlessness, mental/mood changes (e.g., excitement, restlessness, confusion, depression, rare thoughts of suicide).confusion, dep
11、ression, rare thoughts of suicide).Symptoms that require urgent medical attention are Symptoms that require urgent medical attention are seizuresseizures 癫痫发癫痫发作作 , problems urinating, problems urinating 排尿排尿 , , abnormal bruisingabnormal bruising 碰碰伤伤 or bleeding,hematemesis or bleeding,hematemesis
12、 呕血呕血 , , fever and rigorsfever and rigors 僵直僵直 , chest pain, hemiplegia, chest pain, hemiplegia, 半身半身不遂不遂 abnormal vision, dyspnea abnormal vision, dyspnea 呼吸困呼吸困难难 and edema. and edema. 水水肿肿 8a Suggestion Suggestion !Dont take QU Mei or any kind Dont take QU Mei or any kind of medicine whose main
13、of medicine whose main ingredient is Sibutramine.ingredient is Sibutramine.More exercise and less food is More exercise and less food is the golden key for losing the golden key for losing weight.weight.If some medicine must be taken If some medicine must be taken for helping losing weight , I for helping losing weight , I recommend Wei Ting.recommend Wei Ting.9a10a
