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1、Definition of ALI & ARDSACCP/SCCM-Criteria, 92 Acute onset PaO2/FiO2 300 for ALI, 200 for ARDS Bilateral parenchymal infilatrates on chest radiograph No clinical evidence of left atrial hypertensionDefinition of SIRS, Sepsis, MODSACCP/SCCM-Criteria, 91SepsisBacteremiaFungemiaParasitemiaViremiaOtherO
2、therTraumaBurnsSIRSInfectionPancreatitisSIRS CARSMARSDefensins cysteine-rich cationic antimicrobial peptides with three disulfide bridges-defensins (6) and -defensins (30) antimicrobial activity chemotactic activity for monocytes, immature dendritic cells and memory T cells vasculogenesis in tumors
3、Role of beta-defensin-1 in ALIModel: Pneumonia & CLP in ratIntervention: Recombinant adenovirus carrying the gene encoding -defensin-2 , intratracheal, 48h priorMonitor: Bacteria clear, inflammation (HE & ICAM), survival ratePathological alteration of lungsCLPCLP & beta-defensin-2Detection of ICAM i
4、n lungCLP CLP & beta- defensin 2Level of ICAM-1 in Lung tissue Optical density (arbitrary units) 0 12 24 36 72 168 0.400.1 0.2 0.3Group CGroup DTime after CLP (hour)* Time after ALI (hours) 10030509080407060Rats with Ad.rBD2Rats with Ad.VSurvival of adenovirus-pretreated rats following CLP24487296120144168 HrsSurvival %Conclusion and Future -defensin-2 had protective role in ALI/ARDS, via both antibacterial effect and modulation of inflammationTime- & Dose- dependent study, genetic association analysis will be helpful for the mechanism and function of defensins in ALI/ARDS.THANKS
