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1、1Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT What is metastasis?Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Cancer Stem Cells motivate and maintain motivate and maintain the growth of cancer the growth of cancer cellscellspotentialitypotentiality plasticityplasticity make them easy to make them easy
2、 to survivesurviveHypothesis of tumor metastasisThe phases of Cancer metastasisThe mechanism of cancer metastasisMalignant Tumor metastasis pathway Tumor metastasisTumor metastasisThe molecules in the metastasis The phases of Cancer metastasisThe phases of Cancer metastasis俞仁涛Invasion(侵犯)Intravasati
3、on（内渗）Extravasation（外渗）Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Invasion1.Stable cell movable cell 2.Protein expression3.Movement mechanismRelative genesDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Intravasation1.Angiogenesis 2.Immune escape Designer:S.G
4、.C.chen8332海. 水. 正. 蓝. 作. 品NEXT ExtravasationThe inverse process of invasionTHE PROCESS OF TUMOR METASTASISDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Malignant Tumor metastasis pathway 恶性肿瘤常见的转移途径恶性肿瘤常见的转移途径Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Common metastasis pathway 1.lymphaticmetastasis淋
5、巴道转移淋巴道转移2.hematogenousmetastasis血道转移血道转移3.implantationmetastasis种植性转移种植性转移Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Process ： cancer cell lymph vessel regional lymph node beyond lymph node hematogenousmetastasis1.LymphaticmetastasizeDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT 2.Hematogenousmetast
6、asisulunglunguliverliverDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Metastasis pathway（1 1） Body vein lung Body vein lung（2 2） Portal vein liver Portal vein liver（3 3） pulmonary veins Total body （ brain 、 bone 、 kidney 、 adrenal glands ） Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT 3.Implantation met
7、astasis ChestCeliacPericardial cavityDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Bioremediation生物治疗生物治疗uLow side effectsuWide rangeuClear goalDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Mechanism of cell metastasisCell adhesion molecule(CAM)Degradation of extracellular matrixMotility of tumor cellsF
8、ormation of vessels Regulation of gene expressionImmunizationDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Cell adhesion molecule(CAM)vCadherinvIntegrinsvSelectinvIgSFvothersDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Degradation of extracellular matrix Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT 丝氨酸蛋
9、白酶类丝氨酸蛋白酶类 半胱氨酸蛋白酶类（半胱氨酸蛋白酶类（ Caspase家族）家族）天冬氨酸蛋白酶类天冬氨酸蛋白酶类 基质金属蛋白酶类（基质金属蛋白酶类（MMPs）Degradation of extracellular matrix vProteoiytic enzymes (蛋白水解酶蛋白水解酶)溶解溶解ECMECM是肿瘤侵袭和转移的天然屏障是肿瘤侵袭和转移的天然屏障Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Motility of tumor cells Motility types: Random movement Directional
10、movement Motility factors:AutoecrineparacrineDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Formation of vesselsTumor metastasis relys on the forming of vessels.Brief Introduction to Molecules in Cancer MetastasisThree SectionspTumour angiogenesisp DisaggregationpIntravasationDesigner:S.G.C.chen8332海.
11、水. 正. 蓝. 作. 品NEXT Tumour angiogenesis pTumour angiogenesis has laid the foundation for tumour survival and tumour metastasis .Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Tumour angiogenesis Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT DisaggregationBroken downDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT DisaggregationUpaCathepsinsMMPsDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT DisaggregationDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Intravasation
