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1、Adaptive immune Adaptive immune responsesresponsesLi WangDepartment of Immunology and MicrobiologyEmail: 1234ContentsCell Mediated ImmunityHumoral Immunity5ContentsCell Mediated ImmunityHumoral Immunity6Cell Mediated Immunity Antigen recognition Lymphocyte activation Antigen elimination Contraction
2、(homeostasis)7 Antigen recognitionCell Mediated Immunity8http:/Exogenous AgEndogenous Ag9Figure 8-1010Self MHC RestrictionCell Mediated Immunity1112APC- T cell Interaction13Cell Mediated Immunity14Cell Mediated Immunity15SMAC (SupraMolecular Activation Cluster)Immunologic synapse16Structure of the i
3、mmunologic synapse Cell Mediated Immunity17Immunologic synapseBetween the T cell and the APC , forming a bulls eyelike structure is called an immunologic synapse or a super-molecular activation cluster (SMAC). The T cell molecules that are rapidly mobilized to the center of the synapse include the T
4、CR, CD4 or CD8 coreceptors.Receptors for Integrins remain at the periphery of the synapse, where they function to stabilize the binding of the T cell to the APC.18 Lymphocyte activation19Figure 8-21Cell Mediated Immunity20Immunoreceptor Tyrosine-based Activation Motifs21222324IL-2Cell Mediated Immun
5、ity25 Activation of a TH cell by both signal 1 and costimulatory signal 2 up-regulates expression of IL-2 and the high affinity IL-2 receptor, leading to proliferation and differentiation.Cell Mediated Immunity2627NaiveCD4+ T Antigen eliminationCell Mediated Immunity28TH129TH230Tfh: Tfh cells secret
6、e IL-21, IL-4 and express CD40L and ICOS that help B cells make high affinity class switched antibody.Th17: Th17 cells secrete IL-17 which stimulates epithelial cells, endothelial cells, fibroblasts and macrophages to secrete a variety of cytokines.Cell Mediated Immunity31Regulatory T Cell (Treg) nT
7、reg: cell-cell contact iTreg: producing CK to suppress immune responseCell Mediated Immunity32CD8+ T cellsCell Mediated Immunity33CTLs Kill Target Cells Cell Mediated Immunity34CTLs Kill Target Cells Cell Mediated Immunity35Cell Mediated Immunity36医学免疫学上海第二医科大学免疫教研室Cell Mediated Immunity37 Contracti
8、on (Homeostasis)Activation-induced cell death (AICD) : Apoptosis of activated lymphocytes, generally used for T cells, considered Fas-mediated apoptosis.Cell Mediated Immunity3839Cell Mediated ImmunityHumoral ImmunityContents40TD and TI AntigensHumoral Immunity41TD AntigenHumoral Immunity42Abbas et
9、al. Cellular and Molecular Immunology.Abbas et al. Cellular and Molecular Immunology. 7e7eHumoral Immunity4344AgplasmaAPCBTh2Ab“1”“2”CD40CD40LIL-4 -5 -6“2”“1”“1”: Antigen recognition“2”: Co-stimulatory signalsHumoral Immunity45BCR ComplexHumoral Immunity Antigen recognition46BCR ClusteringHumoral Im
10、munity47Humoral Immunity48Co-receptorCo-receptorHumoral Immunity495051Humoral Immunity52Humoral Immunity53Abbas et al. Cellular and Molecular Immunology.Abbas et al. Cellular and Molecular Immunology. 7e7eGerminal CenterHumoral Immunity54Humoral Immunity55Follicular dendritic cells56 Germinal center
11、: Specialized structure in lymphoid organs generated during T-dependent humoral immune responses, where extensive B cell proliferation, somatic mutation, affinity maturation, isotype switching, memory B cell generation, and induction of plasma cells take place. Humoral Immunity57Somatic Mutation and
12、 Affinity maturationHumoral Immunity5859Isotype SwitchingHumoral Immunity60Abbas et al. Cellular and Molecular Immunology.Abbas et al. Cellular and Molecular Immunology. 7e7eHumoral Immunity61Plasma cells and antibody productionAbbas et al. Cellular and Molecular Immunology.Abbas et al. Cellular and
13、 Molecular Immunology. 7e7eHumoral Immunity62Memory B cellsHumoral Immunity636465Humoral Immunity66Humoral Immunity67TD and TI Antigens68TI-1: LPS69TI-270Adaptive Immunity71ContentsCell Mediated ImmunityHumoral Immunity72Review questions:1.Describe the dual-signal theory of T cell activation.2.Descr
14、ibe the effect function of T cell subsets3.Describe cytokine profiles of the Th1 and Th2 subsets.4.Briefly describe the signal transduction pathway in T cell activation.5.Describe the interaction between Th cells and B cells in the immune response to TD Ags.6.Describe the difference between B1 and B2.7.Describe the differences between primary and secondary immune response in Ab production.8.Describe the cytokines that participate in isotype switching.7374
