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1、卡泊三醇软膏和焦油治疗慢性斑片状银屑病比较卡泊三醇软膏和焦油治疗慢性斑片状银屑病比较目的比较达力士和焦油的有效性、耐受性和安全性S N Tham et al.Br J Derm 1994; 131: 673-677研究设计研究设计新加坡国立大学前瞻性、左/右侧随机，调研者单盲27位受试患者6周 卡泊三醇卡泊三醇 煤焦油煤焦油/石腊石腊卡泊三醇或焦油卡泊三醇或焦油/石腊石腊2周4周开放阶段洗脱期随机治疗阶段比较研究卡泊三醇和焦油治疗慢性斑片性银屑病比较研究卡泊三醇和焦油治疗慢性斑片性银屑病新加坡新加坡随机，调研者单盲，右随机，调研者单盲，右/左对比左对比30位患者位患者 卡泊三醇卡泊三醇 煤焦油
2、煤焦油/ 石蜡石蜡卡泊三醇卡泊三醇或煤焦油或煤焦油/石腊石腊2周6周4周开放期洗脱期Source: S N Tham et al. Br J Derm 1994; 131: 673-677研究设计研究设计达力士软膏一天两次煤焦油溶液（15）于水性乳膏（15），傍晚白色温和石蜡，早晨皮损对称分布的慢性斑片性银屑病共30位受试患者治疗期的治疗期的PSAI评分评分PASI分值（平均）周标记的银屑病皮损疗评估标记的银屑病皮损疗评估鳞屑 达力士对鳞屑的疗效显著优于焦油浸润达力士对浸润的改善显著优于焦油红斑 达力士对红斑的改善显著优于焦油研究者和患者的总体评估研究者和患者的总体评估 焦油 卡泊三醇 焦油
3、卡泊三醇 患者 研究者患者随访期随访期选择达力士的患者：26位选择焦油的患者： 1位安全性安全性 卡泊三醇 焦油* 刺激 11.1%0%*几乎所有的患者以前用焦油治疗过，因而了解焦油的坏气味和色素沾染结论结论达力士显著优于焦油：更有效，患者更易接受，无气味，无色素沾染v-A3F7KcPhUmYr%w-B3F8KdPiUmZr&w+B3G8LdQiUnZs&x+B4G9LeQiVn#s*x+C4H9MeQjVo#t*x0C5HaMeRjWo!t*y0D5IaMfRkWp!t(y1D6IaNfSkXp!u(z1E6IbNgSlXp$u)z2E6JbOgTlXq$v)A2E7JcOhTlYq%v-A
4、2F7KcPhTmYr%w-A3F8KdPhUmZr&w-B3G8LdPiUnZs&w+B4G9LdQiVn#s&x+C4H9LeQjVo#s*x0C5H9MeRjWo#t*y0D5HaPiUnZs&w+B4G9LdQiVn#s&x+C4H9LeQjVo#s*x0C5H9MeRjWo#t*y0D5HaMfRkWo!t(y1D5IaNfSkWp!u(z1D6IbNgSkXp$u)z1E6JbOgSlXq$v)z2E7JcOgTlYq%v)A2F7KcOhTmYr%v-A3F8KcPhUmZr%w-B3G8KdPiUnZr&w+B4G8LdQiVnZs&x+C4G9LeQjVn#s*x0C4H9M
5、eRjVo#t*y0C5HaMfRjWo!t(y0D5IaNfRkWp!u(y1D6IbNfSkXp$u(z1E6JbNgSlXq$u)z2E7JbOgTlYq$v)A2F7KcOhTmYr%v-A3F8KcPhUmZr%w-B3G8KdPiUnZr&w+B4G8LdQiVnZs&x+C4G9LeQjVn#s*x0C4H9MeRjVo#t*y0C5HaMfRjWo!t(y0D5IaNfRkWp!u(y1D6IbNfSkXp$u(z1E6JbNgSlXq$u)z2E7JbOgTlYq$v)A2F7JcOhTmYq%v-A3F7KcPhUmYr%w-B3F8KdPiUmZr&w+B3G8LdQiU
6、nZs&x+B4G9LeQiVn#s*x+C4H9MeQjVo#t*x0C5HaMeRjWo!t*y0D5IaMfRkWp!t(y1D6IaNfSkXp!u(z1E6IbNgSlXp$u)z2E6JbOgTlXq$v)A2E7JcOhTlYq%v-A2F7KcPhTmYr%w-A3F8KdPhUmZr&w-B3G8LdPiUnZs&w+B4G9LdQiVn#s&x+C4H9LeQjVo#s*x0C5H9MeRjWo#t*y0D5HaMfRkWo!t(y1D5IaNfSkWp!u(z1D6IbNgSkXp$u)z1E6JbOgSlXq$v)z2E7JcOgTlYq%v)A2F7KcOhTmYr%
7、v-A3F8KcPhUmZr%w-B3G8KdPiUnZr&w+B4G8LdQiVnZs&x+C4G9LeQjVn#s*x0C4H9MeRjVo#t*y0C5HaMfRjWo!t(y0D5IaNfRkWp!u(y1D6IbNfSkXp$u(z1E6JbNgSlXq$u)z2E7JbOgTlYq$v)A2F7JcOhTmYq%v-A3F7KcPhUmYr%w-B3F8KdPiUmZr&w+B3G8LdQiUnZs&x+B4G9LeQiVn#s*x+C4H9MeQjVo#t*x0C5HaMeRjWo!t*y0D5IaMfRkWp!t(y1D6IaNfSkXp!u(z1E6IbNgSlXp$u)z2
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10、Yr%w-B3F8KdPiUmZr&w+B3G8LdQiUnZs&x+B4G9LeQiVn#s*x+C4H9MeQjVo#t*x0C5HaMeRjWo!t*y0D5IaMfRkWp!t(y1D6IaNfSkXp!u(z1E6IbNgSlXp$u)z2E6JbOgTlXq$v)A2E7JcOhTlYq%v-A2F7KcPhTmYr%w-A3F8KdPhUmZr&w-B3G8LdPiUq$v)A2E7JcOhTlYq%v-A2F7KcPhTmYr%w-A3F8KdPhUmZr&w-B3G8LdPiUnZs&w+B4G9LdQiVn#s&x+C4H9LeQjVo#t*x0C5HaMeRjWo!t*y
11、0D5IaMfRkWp!t(y1D6IaNfSkXp!u(z1E6IbNgSlXp$u)z2E6JbOgTlXq$v)A2E7JcOhTlYq%v-A2F7KcPhTmYr%w-A3F8KdPhUmZr&w-B3G8LdPiUnZs&w+B4G9LdQiVn#s&x+C4H9LeQjVo#s*x0C5H9MeRjWo#t*y0D5HaMfRkWo!t(y1D5IaNfSkWp!u(z1D6IbNgSkXp$u)z1E6JbOgSlXq$v)z2E7JcOgTlYq%v)A2F7KcOhTmYr%v-A3F8KcPhUmZr%w-B3G8KdPiUnZr&w+B4G8LdQiVnZs&x+C4G
12、9LeQjVn#s*x0C4H9MeRjVo#t*y0C5HaMfRjWo!t(y0D5IaNfRkWp!u(y1D6IbNfSkXp$u(z1E6JbNgSlXq$u)z2E7JbOgTlYq$v)A2F7JcOhTmYq%v-A3F7KcPhUmYr%w-B3F8KdPiUmZr&w+B3G8LdQiUnZs&x+B4G9LeQiVn#s*x+C4H9MeQjVo#t*x0C5HaMeRjWo!t*y0D5IaMfRkWp!x+B4G9LeQiVn#s*x+C4H9MeQjVo#t*x0C5HaMeRjWo!t*y0D5IaMfRkWp!t(y1D6IaNfSkXp!u(z1E6IbNgS
13、lXp$u)z2E6JbOgTlXq$v)A2E7JcOhTlYq%v-A2F7KcPhTmYr%w-A3F8KdPhUmZr&w-B3G8LdPiUnZs&w+B4G9LdQiVn#s&x+C4H9LeQjVo#s*x0C5H9MeRjWo#t*y0D5HaMfRkWo!t(y1D5IaNfSkWp!u(z1D6IbNgSkXp$u)z1E6JbOgSlXq$v)z2E7JcOgTlYq%v)A2F7KcOhTmYr%v-A3F8KcPhUmZr%w-B3G8LdPiUnZs&w+B4G9LdQiVn#s&x+C4H9LeQjVo#s*x0C5H9MeRjWo#t*y0D5HaMfRkWo!
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16、OgSlXq$v)z2E7JcOgTlYq%v)A2F7KcOhTmYr%v-A3F8KcPhUmZr%w-B3G8KdPiUnZr&w+B4G8LdQiVnZs&x+C4G9LeQjVn#s*x0C4H9MeRjVo#t*y0C5HaMfRjWo!t(y0D5IaNfRkWp!u(y1D6IbNfSkXp$u(z1E6JbNgSlXq$u)z2E7JcOgTlYq%v)A2IaNfSkWp!u(z1D6IbNgSkXp$u)z1E6JbOgSlXq$v)z2E7JcOgTlYq%v)A2F7KcOhTmYr%v-A3F8KcPhUmZr%w-B3G8KdPiUnZr&w+B4G8LdQiVn
17、Zs&x+C4G9LeQjVn#s*x0C4H9MeRjVo#t*y0C5HaMfRjWo!t(y0D5IaNfRkWp!u(y1D6IbNfSkXp$u(z1E6JbNgSlXq$u)z2E7JbOgTlYq$v)A2F7JcOhTmYq%v-A3F7KcPhUmYr%w-B3F8KdPiUmZr&w+B3G8LdQiUnZs&x+B4G9LeQiVn#s*x+C4H9MeQjVo#t*x0C5HaMeRjWo!t*y0D5IaMfRkWp!t(y1D6IaNfSkXp!u(z1E6IbNgSlXp$u)z2E6JbOgTlXq$v)A2E7JcOhTlYq%v-A2F7KcPhTmYr%w
18、-A3F8KdPhUmZr&w-B3G8LdPiUnZs&w+B4G9LdQiVn#s&x+C4H9LeQjVo%w-B3F8KdPiUmZr&w+B3G8LdQiUnZs&x+B4G9LeQiVn#s*x+C4H9MeQjVo#t*x0C5HaMeRjWo!t*y0D5IaMfRkWp!t(y1D6IaNfSkXp!u(z1E6IbNgSlXp$u)z2E6JbOgTlXq$v)A2E7JcOhTlYq%v-A2F7KcPhTmYr%w-A3F8KdPhUmZr&w-B3G8LdPiUnZs&w+B4G9LdQiVn#s&x+C4H9LeQjVo#s*x0C5H9MeRjWo#t*y0D5H
19、aMfRkWo!t(y1D5IaNfSkWp!u(z1D6IbNgSkXp$u)z1E6JbOgSlXq$v)z2E7JcOgTlYq%v)A2F7KcOhTmYr%v-A3F8KcPhUmZr%w-B3G8KdPiUnZr&w+B4G8LdQiVnZs&x+C4G9LeQjVn#s*x0C4H9MeRjVo#t*y0C5HaMfRjWo!t(y0D5IaQiVn#s&x+C4H9LeQjVo#s*x0C5H9MeRjWo#t*y0D5HaMfRkWo!t(y1D5IaNfSkWp!u(z1D6IbNgSkXp$u)z1E6JbOgSlXq$v)z2E7JcOgTlYq%v)A2F7KcOhTmYr%v-A3F8KcPhUmZr%w-B3G8KdPiUnZr&
