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1、拉莫三嗪和丙戊酸钠联合治疗儿童难治性癫痫临床观察目的观察拉莫三嗪和丙戊酸钠联合治疗儿童难治性癫痫的临床疗效。方法将 89例儿童难治性癫痫患者分为两组,研究组 45 例给予拉莫三嗪和丙戊酸钠联合 治疗,对照组 44 例给予单纯拉莫三嗪治疗。结果研究组、对照组总有效率分别 为 86.78%、 72.73% ,研究组总有效率较高,其治疗后 EEG 平均好转时间较短, 两组差异有统计学意义(PV0.05)。结论拉莫三嗪和丙戊酸钠联合治疗儿童难治 性癫痫,总有效率高,EEG平均好转时间短。Abstract:ObjectiveTo observe the clinical curative effect
2、of lamotrigine and sodium valproate in the treatment of refractory epilepsy in children. Methods89 cases of children with intractable epilepsy patients were divided into two groups, study group 45 patients were treated with lamotrigine and sodium valproate therapy, 44 cases in the control group trea
3、ted with lamotrigine treatment. ResultsThe study group, the control group total effective rate was 97.78%, 72.73%, study group total efficiency is high, the average EEG improvement after the treatment time is short, with a significant difference between two groups (P 0.05)。1.2方法研究组45例给予拉莫三嗪联合丙戊酸钠治疗,
4、即选择拉莫三嗪(由 GlaxoSmithKline Pharmaceuticals SA 生产,批准文号:国药准字 J20130026) 2mg /(kgd), 口服,1次/d,之后可根据患儿的实际情况适当增加剂量,但不宜超过 10mg/(kgd),同时选择丙戊酸钠(由西安第四制药厂生产,批准文号:国药准 字H61021048) 15mg/(kgd),之后可参照患儿的实际情况适当增加剂量,但不 宜超过40mg/(kgd),两种药物均需持续应用90d1。对照组44例给予单纯拉 莫三嗪治疗,其药物生产厂家、剂量、使用方法、疗程等与研究组拉莫三嗪相同。 两组患儿治疗期间均需加强病情观察,常规给予脑电图(EEG)检查,并详细记 录 EEG 的好转时间。