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1、 十二烯基疏水改性海藻酸钠的胶束化性能研究摘 要海藻酸钠是由-D-甘露糖醛酸(M)和-L-古罗糖醛酸(G)构成的由褐藻中提取的一种天然线性多糖,。海藻酸钠在人体中具有良好的非应答性，微生物降解性以及无毒性，。本文主要是针对海藻酸钠亲水性不佳，无法对疏水性药物进行好的包覆进行了改性，并研究了疏水改性海藻酸钠的性质。其中包括产品的粘度，粒径，zeta电位，包药后的吸光度等各种手段对其结构和性能进行了表征，同时系统的研究了疏水改性海藻酸钠的胶束化形为，以及针对他疏水性药物的包覆行为进行了评估1通过在表面活性剂的催化作用下，在中性环境中，以十二烯基丁二酸酐为疏水性截肢原料，对海藻酸钠进行改性，产物为具
2、有两亲性的衍生物DSA，在水溶液中形成胶束，其结构为内壳具有疏水性的烯基链，外核为具有亲水性的海藻酸钠2通过对一系列浓度梯度的海藻酸钠溶液的表面张力测量发现在xxx浓度下表面张力减小趋势变缓，可得出xxx浓度为临界胶束浓度3通过疏水药物在不同浓度下的疏水改性的海藻酸钠溶液中的吸光度的测量发现DSA对疏水性药物具有一定的增溶能力，可以使氯法齐明在溶液中的溶解度显著提高4通过对氯法齐明该类疏水性药物的包药实验，证明了疏水性药物可以被胶束中具有疏水性的内核所包覆5通过测定改性后海藻酸钠粒度分布，发现粒度分布范围变小变集中。在整个浓度范围内，在xxx左右时粒径曲线出现的转折点，与胶束形成过程相对应。6
3、通过对DSA粒径大小，与ZETA电位的测量，其胶束粒径为xxx，zeta电位为xxx关键词：海藻酸钠，疏水改性，临界胶束浓度，增溶作用，zeta电位，粒径STUDY ON THE MICELLIIZATION OF SODIUM DODECYL HYDROP HOBICALLY MODIFIED SODIUM ALGINATEABSTRACTSodium alginate is composed of -D- (M) -L- and polymannuronate guluronic acid (G) a natural linear extracted from brown algae po
4、lysaccharide composition,. Alginate has good non immunity, biodegradability and innocuity,. In this paper, hydrophobic properties of hydrophobic polymers were studied by using twelve alkenyl butyl two anhydride for hydrophobic properties of sodium alginate, and the properties of modified polymers we
5、re studied. Including product viscosity, particle size, zeta potential, its structure and properties were characterized. The absorbance after administration of various means on the micellization behavior of modified sodium alginate in aqueous solution were studied, and it is on the solubility of hyd
6、rophobic drugs and of ester soluble dye the emulsification of inquiry1 the catalytic action of surfactants, in the neutral environment, with twelve alkenyl Ding two anhydride as raw materials of hydrophobic amputation, sodium alginate modified, the products have two amphiphilic derivatives DSA, the
7、formation of micelles in aqueous solution, the structure of alkenyl chain with hydrophobic inner shell the outside core is hydrophilic, sodium alginate2 by measuring the surface tension of a series of concentration gradient solutions of sodium alginate solution, it is found that the trend of surface
8、 tension decreases at XXX concentration, and XXX concentration is the critical micelle concentrationThrough the measurement of 3 hydrophobic hydrophobic drugs in different concentrations of the absorbance change of sodium alginate solution in the discovery of DSA has the ability to solubilize hydrop
9、hobic drugs, can make the chlorine solubility clofazimine in solution significantly increased4 by observing the dissolution of Sudan in hydrophobic modified alginate solution, it can be concluded that lipid soluble Sudan red can be loaded into the hydrophobic core of DSA and increase its solubility
10、in aqueous solution.5 by measuring the size distribution of modified sodium alginate, it is found that the size distribution range becomes smaller and concentrated. In the whole concentration range, around XXX, the turning point of the particle size curve is corresponding to the micelle formation pr
11、ocess.6 by measuring the size of DSA and the measurement of ZETA potential, the particle size of micelle is XXX, and the potential of zeta is XXXKeywords: alginate, hydrophobic modification, critical micelle concentration, solubilization, zeta potential, particle size目 录第一章 前言11.1 海藻酸钠11.1.1海藻酸钠的定义.
12、11.1.2海藻酸钠的功能.21.1.3海藻酸盐改性的目的.31.1.4海藻酸钠的截枝.41.1.4.1酯化法.51.1.4.2酰胺化法.51.1.4.3开环法. 6 2. 实验部分.62.1 仪器和试剂.72.2. 两亲性海藻酸钠的制备.72.3疏水改性海藻酸钠表面张力的测定72.5 十二烯基海藻酸钠水溶液粒径和粒度分布的测定.72.6 十二烯基海藻酸钠对氯法齐明的包药效果的测定.83 结果与讨论.83.1 十二烯基海藻酸钠的合成.83.2 十二烯基海藻酸钠水溶液表面张力的测定.93.3 十二烯基海藻酸钠水溶液Zeta电位的测定103.4 十二烯基海藻酸钠胶束的粒径和粒度分布.11结 论12
13、参考文献121.1 海藻酸钠1.1.1 海藻酸钠的定义海藻酸又名褐藻胶从褐藻或者一些细菌中提取（比如固氮菌），在海藻中存在。由于细胞间的基底膜的存在使得藻类不仅具有灵活性而且兼顾稳定性，海藻酸是从海水中提取碘的副产物，也被直接运用到食品，制药，和化妆工业。海藻酸钠是海藻酸盐的主要利用对象，一般是作为食品中的增稠剂与药品中的凝胶剂使用。海藻酸钠是一种通过-1,4糖苷键由两种糖醛酸-L-古洛糖醛酸（G单元）和-D-甘露糖醛酸（M单元）相链接的天然线性多糖，甘露糖醛酸与古洛糖醛酸作为均聚物单元以M-M、G-G和M-G的组合方式形成一种无支链的线性嵌段共聚物这两个单元在凝胶化作用中都起到决定性作用，尤
14、其是G单元为锯齿形,1其平均分子量为48000186000gmol1.2其结构式如下图由于海藻酸的收获时间的不同，其种类，结构也有所不同3。在自然环境中其主要是与钡离子，钾离子，钠离子等形成的盐类化合物4。其中的两个单元的pKa值也有所不同，其大小为3.38，3.65 5。但是海藻酸的pKa为3.4-4.4左右，其值与海藻酸的种类，盐的种类有关5。如果向海藻酸钠溶液中加入二价阳离子其结构就会变成凝胶状态，这是因为海藻酸钠带负电会与二价阳离子相结合的缘故 14。其盐链的结构决定了海藻酸的理化性质。海藻酸钠可以与水很好的相溶形成水溶液，其溶解能力与温度有关6。在酸性溶液中海藻酸钠容易析出沉淀，当处于碱性溶液中其又会变成黏性溶液7。且其粘性与海藻酸的分子量呈正相关8
