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1、新视野系列研究生课程：科技论文的构思、撰写和发表生物医学世纪讲坛特邀报告：How to Publish Your Papers in the Top Scientific Journals鲁白教授What Is a First-Class Paper?Major advance in a classic field干细胞是如何分化成特定组织细胞的，胆固醇在人体的正常功用干细胞是如何分化成特定组织细胞的，胆固醇在人体的正常功用 New techniques and methods that can be widely used人类基因组研究中的自动测序技术人类基因组研究中的自动测序技术 , PC
2、R, Patch clampDiscoveries with obvious practical implicationsAIDS virus receptor 的发现, 老年痴呆症基因的发现AIDS virus receptor 的发现, 老年痴呆症基因的发现Conceptual breakthrough, novel ideas神经营养因子可以促进学习记忆神经营养因子可以促进学习记忆Challenge to traditional views, break dogma脑内有可分裂的神经干细胞，打破了传统观念脑内有可分裂的神经干细胞，打破了传统观念Opening up new area, c
3、ross board“细胞凋亡细胞凋亡”现象的发现, 开辟了新的科研领域现象的发现, 开辟了新的科研领域What Is a Mediocre Paper? Horizontal growthI made the discovery in rats, you find the same in cat. Filling gapsEGF activates JNK which is known to induce c-Jun expression. You show that EFG enhances c-Jun expression. Working out detailsI found NO i
4、nduces the production of cGMP, you work out dose response and time course. Support existing idea, “me too”EGF-R endocytosis requires dynamin, PDGF-R too. Follow up CREB binds to CRE. Working out CRE sequence. Incomplete study, preliminaryHow to Read Scientific Papers? The Gilbert way Keep these in m
5、ind when you readWhat is the major question addressed in this paper? Is this question important and why? What are the approaches used in this paper, and whether they are adequate for the questions? What are the novel idea or using innovative approaches? What is the concept coming out of this paper?
6、Do the results presented support this new concept? Weekly reading of CNS titles Critical, appreciativeArticlesAn RNA Thermosensor Controls Expression of Virulence Genes in Listeria monocytogenes Jrgen Johansson, Pierre Mandin, Adriana Renzoni, Claude Chiaruttini, Mathias Springer, and Pascale Cossar
7、tSingle-Stranded Antisense siRNAs Guide Target RNA Cleavage in RNAi Javier Martinez, Agnieszka Patkaniowska, Henning Urlaub, Reinhard Lhrmann, and Thomas TuschlOcaB Is Required for Normal Transcription and V(D)J Recombination of a Subset of Immunoglobulin gene Rafael Casellas, Mila Jankovic, Gesa Me
8、yer, Anna Gazumyan, Yan Luo, Robert G. Roeder, and Michel C. NussenzweigCellSeptember 6, 2002: 110 (5)Pages551561563574575585587597A Structural Mechanism of Integrin IIb 3Inside-Out Activation as Regulated by Its Cytoplasmic Face Olga Vinogradova, Algirdas Velyvis, Asta Velyviene, Bin Hu, Thomas A.
9、Haas, Edward F. Plow, and Jun QinGlobal Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling Junichi Takagi, Benjamin M. Petre, Thomas Walz, and Timothy A. SpringerAppA Is a Blue Light Photoreceptor that Antirepresses Photosynthesis Gene Expression i
10、n Rhodobacter sphaeroides Shinji Masuda and Carl E. Bauer599611613623What Makes Good Science? Important and significant Original and innovative Solid and rigorous Unique and unusualNovelty is essential语不惊人誓不休语不惊人誓不休杜甫杜甫MarathonEditorial Policies of Different Journals Cell/Neuron/Immunity Editorial b
11、oard does a lot of reviews. Editors discuss and decide Nature sister journals Editors discuss and decide Science Space meeting, editorial board PNAS Communicate, contribute, Track 3 OthersProcedures for High Profile Journals Pre-submission inquiry Submit/cover letter Initial screen Send out for revi
12、ews Reject/soft reject/revise Rebuttal Revise again Accept significance/importance general interests unusual/surprising news worthyInitial screening suggest reviewers, may take one friends may not always support you “not to review” always honored “soft” and “harsh” reviewersSelection of reviewersYou
13、EditorsPope and EditorCover Letters main findings significance suggested reviewers “not to review” list who have readDear Editor,We would like to submit the enclosed manuscript entitled “GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons“, whi
14、ch we wish to be considered for publication in Nature Neuroscience. GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinsons disease. In this paper, we report an unexpected, acute effect of GDNF on A-type pot
15、assium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first t
16、ime, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinsons disease.Due to a direc
