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1、#D8# cI| 1007-3949( 2010) 18-07-0582-04CD36与动脉粥样硬化综述,审校(北京大学人民医院心脏中心, 北京市 100044)1oM CD36; 动脉粥样硬化; 清道夫受体K 1 CD36是在多种组织细胞上表达的跨膜糖蛋白,属于 B族清道夫受体b单核巨噬细胞上的 CD36是吞噬摄取氧化型低密度脂蛋白的主要受体b除介导泡沫细胞形成外, CD36还有促进凝血和单核细胞聚集,促进炎症反应和氧化a凋亡等多种功能,其表达可被高度调控,是巨噬细胞泡沫化和动脉粥样硬化发生发展的重要因素bms| R363 DSM ACD36 and AtherosclerosisJIN W
2、 en-Y ing, and CHEN Hong(Cardiac Center, People sHospital ofPeking University, Beijing 100044, China)KEYWORDS CD36; A therosclerosis; ScavengerReceptorABSTRACT CD36, belongs to classB scavenger receptor fam ily, is a transmembrane glycoprotein expressed on va-rious tissues. Onmacrophages, CD36 is a
3、major scavenger receptor for oxidized low density lipoprotein( ox-LDL). In add-ition to its significant roles in atherosclerosis, CD36 also exertsmultiple roles including promoting coagulation andmonocytesaccumulation, pro-inflammatory and antioxidant roles, etc. The expression of CD36 is highly reg
4、ulated by many factors,and plays an important role in the development of atherosclerosis.l 2010-02-11 2010-04-09Te ,pV,D=,Z_#5%h1, E-mailjjwyy sina. combYT,q,pV3=,1VY$#, E-mailchenhong0418 yahoo. com. cnb( atherosclerosis, As)h3BD3bCD36%VBbs8,%( oxidized low density lipoprotein, ox-LDL)1s8b%YVCD36|v
5、ox-LDL%, CD36VreV?%A s1ybL.CD36C,yNCD36Vr?eV?As1b1 CD363+1. 1 CD36bs8|As%1,bs8ABbs8( scavenger re-ceptor-A, SR-A)BBbs8( SR-B)bSR-AVK|eLDL ox-LDLaY( acetylated low-density lipoprotein, ac-LDL ),/%=%?K%bSR-B1SR-BCD36bSR-B( high-densitylipoprotein, HDL)1s8, CD36SR-B30%,CD36eTSR-AM1bCD36y7|8q11. 2,15A0,
6、32 kbbCD36c471,%s0Y,78 88kDa,SR-B30%bCD36t,NCBtu,K10=,W5s,u,c 1, 2bCD36=5( palm itoylated),CD36A=%Es1b1. 2 CD36s#?CD36i%A,=|.d1bFs, CD36CD36VP%|ox-LDL?50% 9bCD36C%=Vr,A sv%5VrbFebbraio 10LCD36VrAshM, CD36yl%ox-LDL?A, CD36ApoEylJv1ApoEylh76. 5%,iOyl%|ox-LDLvh60%b%MZEApoE /CD36ylCD36VPAshM9F2 11b, M a
7、rleau 12|CD368EP80317ApoEl8=FCD36TVPhMvAr51%bM8=CD36,iCD36Jy?3q9F,VCD36OFM1 13bCD36y8M1 14bTeupser 15L3hCD14( + )%CD36VrA9FbvVCD366,iOvM116b(4UCD36As?3?Z1T, CD36A sT,CD36?VTAsBb2. 2 CD36T2. 2. 1 促进凝血和介导单核细胞的黏附 CD36ls8,l,lsbCD369l( thrombospondin,TSP)s8, CD36-TSPMTll%*, CD36Vox-LDLl 17bHarb18CD36|Y%_
8、AshM*#5CQb7Park 19LCD36l%_C/%Mb2. 2. 2 介导泡沫细胞形成 CD36%ABbs8,VK|ox-LDL(sQ)%b,YeLDL, CD36SR-AT75% 90% 20bCD36SR-Al%+e%?,s8%eLDLV%TbSR-AMYox-LDL,7CD36MYox-LDLbVSR-A1|ac-LDL,7CD36|ox-LDL1s8b%YVCD36s8o|ox-LDL9|40% 9b%Vbs8CD36MY=ox-LDL,H=CD36PPARC,CD36VrV7O1&| 1,K/%?%=,K%box-LDLCD36VBy0Vr,TNFa%1B( IL-1B)aIL-6a( IFN),%b583CN 43-1262/RS2010M1872. 2. 3 CD36与炎症 CD36ox-LDL
