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1、 1? ? ? ?WHO? ? ? ? ? 2006 ?SAGE? ? ? ? ? ? ?2007?12? ? ? ? ? ?http:/www.who.int/immunization/documents/positionpapers/en/index. html? ? ? ? ? ? ? 100 ? ? 99%? ? 33 ?1? ? ? ? 5.5 ? ? ? 2 ? 2/10 ? ? ? 2.4 ? 4/10 ? ? ? 15 ?5?14 ? ? 40%?2?15 ? ? 5 ? 1 Knobel DL et al. Re-evaluating the burden of rabies
2、 in Africa and Asia. Bulletin of the World Health Organization, 2005, 83:360368. 2 WHO Expert Consultation on Rabies: first report. Geneva, World Health Organization, 2005 (WHO Technical Report Series, No. 931; http:/whqlibdoc.who.int/trs/WHO_TRS_931_eng.pdf). 2? ? ? ? 1500 ? ? ? 32.7 ?1? ? ?RABV? ?
3、 2009 ? 11 ? RNA ? 5 ? G ? ? ? ? ? ? ? ? ? ? 1?3 ? ? ? ? ? ? ? ? ? ? ?/? ?3,4,5? ? 30%? ? ? ? ? ?CSF? ?6,7,8,9?3 Laothamatas J et al. MR imaging in human rabies. American Journal of Neuroradiology, 2003, 24:11021109. 4 Hemachudha T et al. Pathophysiology of human paralytic rabies. Journal of Neurovi
4、rology, 2005,11:93100. 5 Jackson AC. Human disease. In: Jackson AC, Wunner AH, eds. Rabies, 2nd ed. London, Elsevier Academic Press, 2007:309340. 6 Crepin P et al. Intra vitam diagnosis of human rabies by PCR using saliva and CSF. Journal of Clinical Microbiology, 1998, 36: 11171121. 7 Dietzschold B
5、 et al. Concepts in the pathogenesis of rabies. Future Virology, 2008, 3:481490. 8 Dacheux L et al. A reliable diagnosis of human rabies based on analysis of skin biopsy specimens. Clinical Infectious Diseases, 2008, 47:14101417. 9 Wacharapluesadee S et al. Ante- and post-mortem diagnosis of rabies
6、using nucleic acid-amplification tests. 3? ? ? ? ? CSF ? CSF ?10? ?8? ? ?11? ? ? 100%?12? ? ? ? ? 40 ?CCV?EEV? ? CCEEVs? ? ? ? ? ? CCEEVs? ?2? 27.2 ?1? ? CCEEVs ? ? ?Vero ? ? ?13? ?Vero?CCVs? ? ? CCVs ? ? ? ? ? 2C ? 8C ? ? ? ? ? 6?8 ? Expert review of molecular diagnostics, 2010,10:207218. 10 Hemach
7、udha T et al. Antemortem diagnosis of human rabies. Clinical Infectious Diseases, 2004, 39:10851086. 11 Bourhy H et al. Comparative field evaluation of the fluorescent-antibody test, virus isolation from tissue culture, and enzyme immunodiagnosis for rapid laboratory diagnosis of rabies. Journal of
8、Clinical Microbiololgy, 1989, 27:519523. 12 Lembo T et al. Evaluation of a direct, rapid immunohistochemical test for rabies diagnosis. Emerging Infectious Diseases, 2006, 12:310313. 13 Plotkin S et al. Rabies vaccines. In: Plotkin SA, Orenstein WA, Offit PA, eds. Vaccines, 5th edition. Saunders Elsevier, 2008:687714. 4?CCVs?2.5IU? ? 0.5ml ? 1.0ml? ? ? ? CCVs ? ? CCVs ?
