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1、河北工业大学博士学位论文磁刺激神门穴诱发脑电信号分析姓名：耿跃华申请学位级别：博士专业：电气工程指导教师：徐桂芝20100501河北工业大学博士学位论文 i 磁刺激神门穴诱发脑电信号分析磁刺激神门穴诱发脑电信号分析 摘摘 要要 磁刺激是一种新型刺激疗法，它利用时变电流流入线圈，在线圈周围产生时变脉冲磁场，并在生物组织内诱发感应电流，从而刺激神经组织。由于其具有无痛、无创及操作简便等明显的优点被广泛应用于运动、认知功能的研究以及相关临床治疗。 现代医学已经证实经穴具有声学、光学、电学、磁学、温度、离子浓度等物理化学相对特异性， 穴位既可探知体内信息变化又可接收外界信息。 针刺作为刺激信息的输入方
2、式已被人们所熟知和应用， 磁刺激在人体穴位部位产生感应电流作用于穴位处感受器， 它同样可以作为一种输入调节信息的方式。 针灸影像学是近年来兴起的一门崭新的学科，通过对磁刺激穴位诱发的脑电信号分析， 从时间或空间上重塑出大脑表皮或内部电信号的特征， 对刺激作用效应进行客观评价，开辟了传统针灸刺激作用效应由主观感知到客观评价的新途径。 本论文将脑电信号分析与穴位磁刺激相结合， 利用非线性信号分析方法和脑源定位技术对不同刺激频率、 不同刺激状态下的脑电信号进行分析对比， 对磁刺激神门穴的作用效应进行分析与评估。主要工作如下： 一、用磁刺激方式刺激肢体神门穴，同时采集诱发的脑电信号进行分析，研究不同频
3、率磁刺激神门穴时引起的脑电信号的变化。实验采用 0.5Hz，1Hz 和 3Hz 三种频率的磁刺激。在每种频率刺激下，研究了安静、磁刺激、假性刺激和假穴四种状态的脑电信号，分组对比了每种状态之间的差异性。 结果显示， 磁刺激穴位状态与其他三种状态均具有一定的特异性， 尤其是与磁刺激假穴状态相比具有特异性， 充分说明磁刺激神门穴对脑功能的确有一定的影响。 二、对实验过程中所采集的脑电信号进行离线处理，对脑电信号的样本熵值进行了计算。结果显示，3Hz 磁刺激组在整个脑区的样本熵值较假穴组有显著降低，1Hz 和 0.5Hz样本熵值无统计学规律。 样本熵值的降低表明大脑脑电信号的复杂度降低， 大脑的状态
4、趋于平稳和有序。因此，从复杂度的分析结果上来看，3Hz 频率磁刺激神门穴对神经兴奋性有较强的抑制作用。 三、提取实验所采集脑电信号的诱发电位，分组观察和比较三种频率刺激下，四种状磁刺激神门穴诱发脑电信号分析 ii 态的脑电诱发电位的幅值。 结果显示， 3Hz 磁刺激的四种状态均无诱发电位， 1Hz 和 0.5Hz磁刺激的磁刺激组与假穴组主要诱发产生代表思维加工的 P150 成份。对刺激组和假穴组的 P150 幅值进行统计学分析，1Hz 磁刺激组的幅值显著高于假穴组，这表明对神门穴进行 1Hz 磁刺激比对非穴位点进行磁刺激能够激发出更多的认知活动。而 0.5Hz 磁刺激刺激组与假穴组相比较无显著
5、差异，3Hz 磁刺激难以从诱发电位角度进行研究。 四、对 1Hz 和 0.5Hz 磁刺激实验的磁刺激组和假穴组的脑电诱发电位 P150 成份进行偶极子溯源分析。结果显示，1Hz 和 0.5Hz 磁刺激组诱发 P150 的几个偶极子全部定位于代表认知和情绪控制功能的扣带回，而假穴组诱发 P150 定位于扣带回，左侧额中回和中央回。可以认为对神门穴进行 1Hz 和 0.5Hz 磁刺激定位的脑功能区域更加集中，且集中于思维信息加工区域。而 1Hz 和 0.5Hz 假穴刺激的脑源定位更加分散，除了定位于代表思维加工的区域，还分散于语言区域，运动区域等，提示磁刺激神门穴对思维功能可能具有靶向调控作用。
6、关键词：磁刺激，神门穴，脑电信号，复杂度，诱发电位，偶极子源定位关键词：磁刺激，神门穴，脑电信号，复杂度，诱发电位，偶极子源定位 河北工业大学博士学位论文 iii EEG EVOKED POTENTIALS ANALYSIS OF MAGNETIC STIMULATION ON ACUPOINT OF SHENMEN(HT7) ABSTRACT Magnetic stimulation is a kind of stimulating therapy, it stimulates neural organization by injecting time-variant current and
7、 induces time-variant pulsed magnetic field to induces current in biological tissues. Because of advantages of painless, non-invasive and operating simply, it is widely used in the study of activity and cognitive function and related clinical treatment. Modern medicine has proved that acupoint has t
8、he physics and chemical relative specificity of acoustics, optics, electricity, magnetic, temperature, ion concentration etc. Acupoint can be seen as an actor which can not only accept information from out of body but also transfer information from body to outside. The acupuncture is familiar to us
9、as a method of stimulation. Magnetic stimulation to acupoint also can be a new stimulation method, it can induce current in tissue to affect and control the information of body. Acupuncture imaging is a new subject which is popular in recent years. The feature of EEG in scalp or inside of brain are
10、imaged in time or space domain by analyzing evoked EEG under stimulation on acupoints. It is a new way to evaluate traditional acupuncture effects by magnetic stimulation on acupoints. This thesis combined EEG analysis with magnetic stimulation on acupoints, compared EEG signals of different frequen
11、cies and different stimulation states using nonlinear analysis and brain source localization techniques, and analyzed and evaluated the effect of magnetic stimulation on Shenmen acupoint. Main tasks as follows: 1. EEG induced by the magnetic stimulation of different frequencies was collected and ana
12、lyzed by magnetic stimulation on Shenmen point. Experiments used three frequencies of 0.5Hz, 1Hz and 3Hz. In each frequency, four states of quiet, magnetic stimulation, mock stimulation and mock point are studied in order to compare the differences between them. The results show that magnetic stimul
13、ation as well as the other three states has a certain degree of 磁刺激神门穴诱发脑电信号分析 iv specificity. It shows that magnetic stimulation on Shenmen has a certain impact on brain function obviously. 2. Signals were processed in off-line after the experiment. Sample Entropy (SampEn) was calculated. The resul
14、ts showed that the SampEn of the 3Hz magnetic stimulation is significantly lower than that of the mock point stimulation, 1Hz and 0.5Hz samples have no statistical significance. Reduction of SampEn indicates that the complexity of the brain lower and the brain become more stable and orderly. Therefo
15、re, the results in the complexity point of view prove that 3Hz frequency magnetic stimulation on Shenmen can strongly inhibite the neural excitability. 3. Evoked potentials of EEG in the experiment were extracted. EEG evoked potential amplitudes in three frequencies and four states were observed and
16、 compared. The results showed that all of four states in 3Hz magnetic stimulation have not evoked potentials, but 1Hz and 0.5Hz magnetic stimulation groups and mock point groups evoked P150 component on behalf of the major thinking process. P150 amplitudes of the stimulation group and the mock point group were analyzed. 1Hz magnetic stimulation amplitude was significantly higher than that of mock acupoint group, which indicated that 1Hz magnetic stimulation on Shenmen can induce more cognitive a
