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1、Hypoxia Signaling Pathway PCR Array 低氧信号通路低氧信号通路 PCR 芯片芯片Catalog No. PAHS- 032A（人）（人） Catalog No. PAMM- 032A（小鼠）（小鼠）The Hypoxia Signaling Pathway RT Profiler PCR Array profiles the expression of 84 genes involved in hypoxia-related signaling. This array includes genes directly involved in the respon
2、se to hypoxia and oxidative stress. Genes associated with the hemoglobin complex are represented as well as genes involved in oxidoreductase activity. Transcription factors and genes involved in regulating transcription are included. Genes involved in the physiological and pathophysiological process
3、es affected by hypoxia on the array include those involved in apoptosis, signal transduction, and protein metabolism as well as genes involved in cell growth and metabolism, extracellular matrix and adhesion molecules, and genes involved in cardiac excitation-contraction coupling. Using real-time PC
4、R, you can easily and reliably analyze expression of a focused panel of genes related to the hypoxia signaling pathway with this array.缺氧信号通路 RT Profiler PCR Array 可以同时测定 84 个与缺氧信号通路有关的基因。这些基因包括 直接与缺氧反应有关的基因、氧化压力。还包括与血红蛋白有关的基因和氧化还原酶类活性调节的基因。 缺氧引起的生理病理过程如凋亡、信号转导、蛋白代谢、细胞生长、代谢、细胞外基质、黏附分子、心 脏兴奋-收缩偶联等有关的
5、基因也包含在内。利用实时定量 PCR，你可以方便并且可信地对与缺氧信号通 路相关的基因进行同时检测。Response to Stress:Response to Hypoxia: ANGPTL4, ARNT2, CREBBP, EP300, HIF1A, MT3, PRKAA1. Response to Oxidative Stress: CAT, CYGB, GPX1, PIP3-E. Immune Response: GPI, IL1A, IL6, IL6ST, NOS2A, NOTCH1, PTX3, RARA. Other Genes Related to Stress Respons
6、e: ADM, EPO, HYOU1, VEGF. Hemoglobin Complex Associated Genes: CYGB, EPO, HBB, HMOX1, NOS2A, PIP3-E. Oxidoreductase:Peroxidase: CAT, CYGB, GPX1, PIP3-E. Other Oxidoreductase-Related Genes: HIF1AN, HMOX1, MT3, NOS2A, PLOD3, TH. Transcription Factors and Regulators:Transcription Cofactors: CREBBP, DR1
7、, ENO1, EP300, EPAS1, HTATIP, RARA. Transcription Factors: ARNT2, BHLHB2, CREBBP, ENO1, EP300, EPAS1, HIF1A, HIF3A, KHSRP, MYBL2, PPARA, RARA. Other Transcription Factors and Regulators: HIF1AN, NOTCH1. Apoptosis:Anti-apoptosis: BAX, ANGPTL4, BIRC5, IL1A, MYBL2, PEA15, PRKAA1, VEGF. Caspase Activity
8、: BIRC5, CASP1. Induction of Apoptosis: BAX, DAPK3, NUDT2. Other Apoptosis Genes: EP300. Signal Transduction: ADM, ARNT2, CASP1, CDC42, CREBBP, EP300, EPAS1, EPO, GNA11, HIF1A, HIF3A, HMOX1, IGFBP1, IL1A, IL6, IL6ST, IQGAP1, KIT, LEP, PLAU, RARA, VEGF. Protein Metabolism:Protein Biosynthesis: EEF1A1
9、, PDIP, PRKAA1, RPL28, RPL32, RPS2, RPS7. Protein Heterodimerization: ARNT2, HIF1A, RARA, SAE1. Protein Homodimerization: ARNT2, RARA, VEGF. Protein Amino Acid Phosphorylation: DAPK3, KIT, PRKAA1. Protein Binding: CASP1, CREBBP, ENO1, EP300, IQGAP1, NOS2A, PEA15, PPP2CB, RARA. Other Genes Related to
10、 Protein Metabolism: ARD1, CDC42, GNA11, HYOU1, MAN2B1, PLOD3, PSMB3, SUMO2, TUBA1. Extracellular Matrix (ECM)-Related Molecules:Protease Inhibitors: BIRC5, CSTB. Protease Molecules: AGTPBP1, CASP1, ECE1, PLAU, PSMB3. Other Extracellular Molecules: ADM, ANGPTL4, CHGA, COL1A1, EPO, IGF2, IGFBP1, IL1A
11、, IL6, LEP, NPY, PTX3, VEGF. Cytoskeleton: DCTN2, SPTBN1. Cell Growth:Cell Cycle: BAX, BIRC5, EP300, HK2, IGF2, IL1A, MYBL2, SSSCA1, VEGF. Cell Proliferation: DCTN2, IGF2, IL1A, IL6, MT3, NPY, RARA, VEGF. Growth Factors: GPI, IGF2, IGFBP1, IL1A, IL6, KIT, VEGF. Other Genes Related to Cell Growth: EN
12、O1. Metabolism:Carbohydrate Metabolism: GPI, HK2, LCT, MAN2B1, PEA15, PRKAA1, SLC2A1, SLC2A4. Lipid Metabolism: AGPAT2, ANGPTL4, PPARA, PRKAA1. One-carbon Compound Metabolism: CA1. Superoxide Metabolism: MT3, NOS2A. RNA Metabolism: FNBP3, KHSRP, RARA, RPL28, RPS2, SNRP70. Other Genes Related to Metabolism: ADM, AGPAT2, MOCS3, NUDT2, TH, TST, UCP2. Cardiac Excitation-Contraction (E-C) Coupling: ARNT2, CHGA, DAPK3, GNA11, IQGAP1, KIT, NOS2A, NOTCH1, NPY, PRKAA1, SPTBN1. 应激反应有关基因；血红蛋白有关基因；氧化还原酶类；转录因子及其有关基因；凋亡有关基因；信号 传导有关基因；蛋白代谢有关基因；细胞外基质相关分子；细胞骨架；细胞生长有关基因；代谢有关基 因；心脏兴奋-收缩偶联有关的基因
