氢呼气试验文献整理

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1、氢呼气试验文献整理氢呼气试验文献整理氢呼气试验文献整理?目前氢呼气试验主要可以做以下几个方面：1、测定乳糖吸收不良症；2、测定小肠菌群过度生长；3、测定口盲传输时间；4、测定胃泌酸功能；目前研究有：一、氢呼气试验的方法优化及影响因素：1、底物：乳糖、葡糖糖、菊粉等底物的选用及比较。【1】Schneider?AR,?Jepp?K,?Murczynski?L,?et?al.?The?inulin?hydrogen?breath?test?accurately?reflects?orocaecal?transit?time.?Eur?J?Clin?Invest.?2007?Oct;37(10):80

2、2-7.?Epub?2007?Aug?28.?PubMed?PMID:?17727672.?菊粉氢呼气试验精确反映口盲传输时间。【2】Berthold?HK,?Schober?P,?Scheurlen?C,?et?al.?Use?of?the?lactose-13Cureide?breath?test?for?diagnosis?of?small?bowel?bacterial?overgrowth:?comparison?to?the?glucose?hydrogen?breath?test.?J?Gastroenterol.?2009;44(9):944-51.?Epub?2009?Jun

3、?24.?PubMed?PMID:?19551459.乳糖（lactose-13Cureide？）呼气试验与葡萄糖氢气呼气试验的比较诊断小肠菌群过度生长。【3】Soares?AC,?Lederman?HM,?Fagundes-Neto?U,?et?al.?Breath?hydrogen?test?after?a?bean?meal?demonstrates?delayed?oro-cecal?transit?time?in?children?with?chronic?constipation.?J?Pediatr?Gastroenterol?Nutr.?2005?Aug;41(2):221-4

4、.?PubMed?PMID:?16056103.儿童便秘患者豆类饮食后呼氢试验显示口盲传输时间的延长。2、禁食：【4】Kumar?S,?Misra?A,?Ghoshal?UC.?Patients?with?irritable?bowel?syndrome?exhale?more?hydrogen?than?healthy?subjects?in?fasting?state.?J?Neurogastroenterol?Motil.?2010?Jul;16(3):299-305.?Epub?2010?Jul?26.?PubMed?PMID:?20680169;?PubMed?Central?PMC

5、ID:?PMC2912123.IBS 患者在禁食状态下比健康人呼出更过的氢气（备注：IBS 患者常有腹胀）【5】Rana?SV,?Sharma?S,?Sinha?SK,?et?al.?Influence?of?previously?ingested?wheat?on?fasting?breath?hydrogen?in?celiac?patients.?Dig?Dis?Sci.?2009?Jun;54(6):1276-9.?Epub?2008?Oct?29.?PubMed?PMID:?18958623.食用小麦对乳糜泻患者禁食呼氢试验的影响。【6】Jonderko?K,?Janikowska?

6、A,?Kasicka-Jonderko?A,?et?al.?Measurement?of?the?orocaecal?transit?time?after?an?oral?lactulose?load-does?the?fasting?breath?hydrogen?concentration?affect?the?feasibility?of?the?test?Wiad?Lek.?2008;61(4-6):107-12.?Polish.?PubMed?PMID:?18939360.口服乳果糖后口盲传输时间的测试：禁食呼氢浓度是否影响该试验的可行性？3、缩短检测时间的研究：【7】Tursi?A

7、.?Three-hour?hydrogen?breath?test?for?assessing?lactose?malabsorption?in?clinical?practice:?to?give?50?or?20?grams?of?lactose?Dig?Dis?Sci.?2006?Jan;51(1):138-9.?PubMed?PMID:?16416226.3小时的氢呼气试验评估乳糖吸收障碍的临床实践：50 还是 20 克乳糖？【8】Di?Camillo?M,?Marinaro?V,?Argnani?F,?et?al.?Hydrogen?breath?test?for?diagnosis

8、?of?lactose?malabsorption:?the?importance?of?timing?and?the?number?of?breath?samples.?Can?J?Gastroenterol.?2006?Apr;20(4):265-8.?PubMed?PMID:?16609755;?PubMed?Central?PMCID:?PMC2659903.氢呼气试验诊断乳糖吸收障碍：呼气样本的数量和时间的重要性。4、影响因素：一般指标：BMI、性别、年龄、?疾病、服用药物等。5、气体收集：糖在肠道细菌的分解下产生氢气和甲烷，单独收集氢气还是甲烷和氢气一起收集也需要探讨。备注：医学研

9、究是一个需要大量验证的过程，很多仅有一至两篇文献作为证据，我们可以依据其进行扩展或在临床实践中发现不同，可以发表不同的观点，挑战经典或者权威。?二、诊断试验评价与一致性检验1、乳糖吸收不良症：【9】Pohl?D,?Savarino?E,?Hersberger?M,?et?al.?Excellent?agreement?between?genetic?and?hydrogen?breath?tests?for?lactase?deficiency?and?the?role?of?extended?symptom?assessment.?Br?J?Nutr.?2010?Sep;104(6):900

10、-7.?Epub?2010?Apr?19.?PubMed?PMID:?20398434.氢气呼气试验和基因检测在乳糖酶缺乏及其相关症状评估中作用一致。【10】Babu?J,?Kumar?S,?Babu?P,?et?al.?Frequency?of?lactose?malabsorption?among?healthy?southern?and?northern?Indian?populations?by?genetic?analysis?and?lactose?hydrogen?breath?and?tolerance?tests.?Am?J?Clin?Nutr.?2010?Jan;91(1)

11、:140-6.?Epub?2009?Nov?4.?PubMed?PMID:?19889824.应用基因分析、乳糖氢气呼气和乳糖耐受测试对健康南部和北部印第安人群乳糖吸收障碍的流行（备注：氢呼气试验为金标准基因检测为新方法）2、小肠菌群过度生长：1）IBS，正常与 IBS 对照组进行氢呼气试验，IBS 组氢呼气增多，但小肠菌群过度生长是否是 IBS 的病因仍具争议。?【11】Ford?AC,?Spiegel?BM,?Talley?NJ,?Moayyedi?P.?Small?intestinal?bacterial?overgrowth?in?irritable?bowel?syndrome:?s

12、ystematic?review?and?meta-analysis.?Clin?Gastroenterol?Hepatol.?2009?Dec;7(12):1279-86.?Epub?2009?Aug?12.?Review.?PubMed?PMID:?19602448.?IBS 中小肠菌群过度生长：荟萃分析。2）小肠菌群过度生长与药物?【12】Lombardo?L,?Foti?M,?Ruggia?O,?Chiecchio?A.?Increased?incidence?of?small?intestinal?bacterial?overgrowth?during?proton?pump?inh

13、ibitor?therapy.?Clin?Gastroenterol?Hepatol.?2010?Jun;8(6):504-8.?Epub?2010?Jan?6.?PubMed?PMID:20060064.PPI 治疗期间小肠菌群过度生长发病率增加。3）小肠菌群过度生长与其他疾病【13】Schneider?AR,?Klueber?S,?Posselt?HG,?et?al.Application?of?the?glucose?hydrogen?breath?test?for?the?detection?of?bacterial?overgrowth?in?patients?with?cystic

14、?fibrosis-a?reliable?method?Dig?Dis?Sci.?2009?Aug;54(8):1730-5.?Epub?2008?Nov?26.?PubMed?PMID:?19034657.使用葡萄糖氢呼气试验检测胆囊纤维化患者的菌群过度生长是否是一个可靠的方法？Fridge?JL,?Conrad?C,?Gerson?L,et?al.?Risk?factors?for?small?bowel?bacterial?overgrowth?in?cystic?fibrosis.?J?Pediatr?Gastroenterol?Nutr.?2007?Feb;44(2):212-8.?

15、PubMed?PMID:?17255834.胆囊纤维化患者小肠菌群过度生长的风险因素。【14】Mancilla?A?C,?Madrid?S?AM,?et?al.Small?intestine?bacterial?overgrowth?in?patients?with?chronic?pancreatitis.?Rev?Med?Chil.?2008?Aug;136(8):976-80.?Epub?2008?Oct?7.?Spanish.PubMed?PMID:?18949180.慢性胰腺炎患者的小肠菌群过度生长。备注：氢呼气试验的优点在于便捷、无创，机理在于肠道菌群分解糖类产生氢气，如果我们能够依据菌群变化机理寻找到一种疾病，可以用呼气实验来替代使用胃肠镜或其他有创手段进行检测或监测疾病，则非常有意义。三、氢气的抗氧化作用（见附录）人体内源性抗氧化物质的量与机体许多疾病的发病相关，最新研究显示呼吸氢气、饮用饱和氢气水、注射饱和氢气生理盐水具有明显的选择性抗氧化作用。人体菌群可以产生氢气、结肠又是一个吸收很活跃的区域，所以，自体产生氢气的量是否也与某些疾病相关，或机体内肠道菌群数量是否与某些疾病的发病相关，也可以作为一个研究的尝试。