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1、林产化工毕业论文林产化工毕业论文题目：苦味酸羧甲基纤维素酯的制备及其对肌酐吸附性能研究 专业： 林产化工 林产化工毕业论文1摘要慢性肾功能衰竭是一种以临床中毒症状为特征的严重疾病，病因主要是体内积蓄了大量的毒素，因此去除体内过量的毒素是治疗慢性肾衰竭的关键，其中尿素和肌酐是患者体内积聚的两种主要毒素。本研究以羧甲基纤维素和苦味酸作为原料，设计合成一种新型治疗慢性肾衰竭的口服性吸附剂-苦味酸羧甲基纤维素酯,并将其应用于对尿素和肌酐的吸附。以羧甲基纤维素（CMC）和苦味酸（PA）做为原料，采用条件温和的酰氯化合成的方法制备苦味酸羧甲基纤维素酯（CMC-PA） 。通过 FTIR、元素分析、XRD、C
2、PMA 13CNMR 等对其结构进行表征，以氮质量分数作为量化指标，考察了反应温度、反应时间、物料比、吡啶的用量对 CMC-PA 制备的影响。红外光谱、元素分析、CPMAS13CNMR 表明 CMC-PA 已生成；通过单因素实验得出合成条件为：m(苦味酸)：m（酰化的羧甲基纤维素）=2：1，吡啶用量为 50ml,反应温度 85C，反应时间 4h，在模拟人体生理介质的条件下，测定了CMC-PA 对肌酐的吸附性能，绘制了吸附动力学曲线，吸附等温曲线。结果表明，CMC-PA对肌酐的吸附平衡时间为 10h,对肌酐的最大吸附量为 1.75mg/g.肌酐在 CMC-PA 上的吸附平衡符合 Freundic
3、h 方程，说明主要是化学吸附，且吸附指数（1/n）小于 1，表明吸附为“优惠吸附” 。关键词关键词：羧甲基纤维素；苦味酸；肌酐；吸附平衡；吸附动力学曲线；吸附等温曲线；林产化工毕业论文Prearation of Carboxymethylcellulose Picric Acid Ester and Adsorption Property for CreatinineAbstractChronic renal failure(CRF)is severe disease which is characterized by clinical symptom of poisoning , depos
4、iting large numbers of toxins in organism is the main cause of CRF,therefore Removal of the excess toxins is the key problem for the treatment of CRF. Urea and creatinine are two of the major toxins to the patient who suffered from chronic renal failure. In this study, the new oral adsorbent named c
5、arboxymethylcellulose-based picric acid(CMC-PA) was prepared from carboxymethylcellulos(CMC) and picric acid(PA) and their adsorption for creatinine and urea were studied.Ether of carboxymethylcellulose-based picric acid(CMC-PA) was prepared from carboxymethylcellulos(CMC) and picric acid(PA) by the
6、 mild reactive conditions of acidylation with chloric.The strcture of CMC-PA was characterized by FTIR,Element analysis,XRD and CPMAS13C NMR.Influences of reaction conditions,such as reaction temperature,recation time,ratio of CMC to PA and amount of pyridine,were studied by mass fraction of nitroge
7、n.CMC-PA had already synthesized by FITR,Element analysisi,and CPMAS13C NMR.Result showed that the synthetical conditions were obtained as ratio of CMC to PA 2 : 1 (by weight),amount of pyridine 50 mL,reaction temperature 85 and reaction time 4 hours.The adsorption property of CMC-PA to creatinine w
8、as studied under smiulated biological human body conditons.The kinetic and isothermy curve were given. Results showed that adsorption amount reached an equilibrium value after 10 hours,and the maxmium adsoption amount was 1.75mg/g.Equilibrium data of creamine fit well with Freundich equation,indicat
9、ing that the adsorption was mainly chemical monolayer adsorat the adsorption was preferential process. Key words: Carboxymetheylcellulose; Picric Acid; creatinine adsorption equilibrium; the kinetic curves of adosrption; the isothermy curves of adsorption;林产化工毕业论文目 录摘要摘要Abstract1 绪论绪论.1 1.1 引言.1 1.2
10、 羧甲基纤维素(CMC)的简介.1 1.2.1 国内外羧甲基纤维素的发展及现状概括.2 1.2.2 羧甲基纤维素的结构特征.2 1.2.3 羧甲基纤维素的物理性质.3 1.2.4 羧甲基纤维素的化学性质.3 1.2.5 羧甲基纤维素在食品上的应用.3 1.2.6 羧甲基纤维素在医药行业的应用.4 1.2.7 羧甲基纤维在其他工业上的应用.4 1.3 研究的主要内容.5 1.4 本课题的创新点及特点.5 2 实验部分实验部分.5 2.1 主要仪器与试剂.5 2.1.1 主要仪器.5 2.1.2 主要试剂.6 2.2 羧甲基纤维素酰氯的制备.6 2.3 苦味酸羧甲基纤维素酯的制备.6 2.4 苦味酸羧甲基纤维素酯的结构表征.
