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1、3 Acta Physiologica Sinica, August 25, 2005, 57 (4): 453-460http:/453Received 2005-02-25 Accepted 2005-05-20This work was supported by the Science and Technology Project of Social Development of Huzhou (No. 2004YS18)*Corresponding author. Tel: +86-571-87217146; E-mail: SBL8 ATPKY5f4F0.05)(m 23aV 2)b
2、2.2 5)9Y5)PHW9#?SAY (m 24aV12)b5/)PH sPCFM1#9 120 minWLVEDPA (P0.05)(m 4)b2.3 L-NAME 5-HD5#TYL-NAME 5-HD/)(AY (m 24aV 12)b L-NAME 5-HD910 minVA5/)P LVEDP (m 2 P0.05) LVDPadP/dtmax3 Cap + sPCFM1A(m 34aV 1 P0.05) LDHdbA Cap + sPCF (V 2 P0.01)b 3 Acta Physiologica Sinica, August 25, 2005, 57(4): 453-46
3、04585 P0.05)3 )LT?C ACEI(5) )/)PVPv#?AT)TMb7BP ACEIi?E)T Susie6 Miki7Lg?CCb-3NCyibw +y= (taF )db?)TA7 ACEIi?)=VFt=Tby VdbtaFVO PKC9F7 PKC)?TA10bQiu15 Shinmura16LVEt# NO8VE)Tlh?3b NO8 L-VYVXVrFv917bK?C L-NAMEVE)T18b NOSd+s4 L-NAMEY5)v cNOS iNOSh NO3tTg$|h9byNw NOV?T1|sm 3. )y LVDPYFig. 3. Recovery of
4、 left ventricular developed pressure (LVDP)during reperfusion after 30 min of ischemia. mean SD, n=7.*P 0.05, *P 0.01 vs sPC group; #P 0.05, #P 0.01 vs Cap +sPC group; $P 0.05 vs Per + sPC group.459f : BL8 ATPKY5f4F/)Tm 4. )y9 dP/dtmaxYFig. 4. Recovery of dP/dtmaxat the end of 120 min of reperfusion
5、 after 30 min of ischemia. meanSD, n = 7. *P 0.01 vs sPC group,#P 0.01 vs Cap + sPC group.m 5. )y# NOYFig. 5. Release of NO in coronary effluent before 30 min ofischemia. meanSD, n = 6. *P 0.05, *P 0.01 vs IS group.019b94QinEt L-NAMEi?|htF?lT10, 20b)TiHM*T)Ci 23 h7TC) 24 hiV 72 hb) 24 h?TF1NT? L-NAM
6、E5bL?C L-NAMEV5)*T4U ACEIF/)*TV?YV NObBL3A NOc?C/) ACEI(V NO39FbwHr NOdb9F?T 7P3xTP NOdb9FV?7TbL mitoKATPYE4 5-HDV|h5)TbSargent?Cc ACE4 zofeno-prilcF n-acetyl cysteineF?MOT(V$ KATPYE4|hb KATPY7b4 cromakalinVEzofenoprilTPxr21b 3 Acta Physiologica Sinica, August 25, 2005, 57(4): 453-460460L?Ccc ACEI4(
7、VYV KATPYTO1 mitoKATPY1b I D1 Murry CE, Jennings RB, Reimer KA. Preconditioning withischemia: a delay of lethal cell injury in ischemic myocardium.Circulation 1986; 74(5): 1124-1136.2 Dana A, Baxter GF, Walker JM, Yellon DM. Prolonging thedelayed phase of myocardial protection: repetitive adenosineA
8、1 receptor activation maintains rabbit myocardium in a pre-conditioned state. J Am Coll Cardiol 1998; 31(5): 1142-1149.3 Chen M, Zhou JJ, Kam KW, Qi JS, Yan WY, Wu S, WongTM. Roles of KATPchannels in delayed cardioprotection andintracellular Ca2+in the rat heart as revealed by kappa-opioidreceptor s
9、timulation with U50488H. Br J Pharmacol 2003;140(4): 750-758.4 Yang X, Zhu Q, Fong J, Gu X, Hicks GL Jr, Bishop SP, WangT. Enalaprilat, an angiotensin-converting enzyme inhibitor,enhances functional preservation during long-term cardiacpreservation. Possible involvement of bradykinin and PKC.J Mol Cell Card
