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1、1,Alzheimers Disease,阿尔茨海默症,2,“I know Im on my way to the twilight. I know theres always a bright dawn ahead of the United states. Thank you, my friends. May God bless you forever.”,3,Catalog,4,brief introduction,1,5,What?,Alzheimers disease (AD) is a progressive neurodegenerative disorder . 临床症状Cli
2、nical symptom 记忆障碍dysmnesia 失语aphasia 失认agnosia 执行功能障碍executive dysfunction 痴呆dementia The disease usually begins after age 60, and risk goes up with age.,6,Two types,Alzheimers disease(AD) 65 years old,senile dementia(SDAT) 65 years old,7,Name,In 1906,AD is named by Dr. Alois Alzheimer, a German do
3、ctor. Dr. Alzheimer noticed changes in the brain tissue of a woman who had died of an unusual mental illness. He found abnormal clumps. Scientists also have found other brain changes in people with AD. Nerve cells die in areas of the brain that are vital to memory and other mental abilities.,8,Clini
4、cal manifestation,2,9,Clinical manifestation,期,期,期,death,1-3 years,2-10 years,8-12 years,Mild dementia,Moderate dementia,Severe dementia,More women than men 7:54:6,Disease for up to 10-20 years,10,Degradation of memory and cognition,William Utermohlen的自画像,11,Degradation of memory and cognition,Willi
5、am Utermohlen is an American artist, in 1995 he was diagnosed with Alzheimers disease. Since then, he has decided to take advantage of the limited time available to retain memory and better understand himself through self portraits. William insisted the 5 New Year paintings self portrait, until comp
6、letely forgotten how to draw. From the use of skilled drawing, dark portrayal of vivid features, to the same color, shape deformation, self portrait became more and more abstract (pictured above).,12,Degradation of memory and cognition,the effects of Alzheimers disease on the right parietal lobe of
7、the brain are particularly severe, which directly affects the ability of the brain to visualize and develop the ability to draw pictures of the brain.said Dr. Bruce Miller, a neurologist. His work became more abstract, may be the parietal function damaged, causing blindness. What kind of changes hav
8、e occurred in the brains of patients with dementia, which is not yet fully understood by the world s academia.,13,PathogenyTreatment,3,14,Pathogenesis hypothesis of AD,15,Pathogeny,Abnormal amyloid beta cell deposition in neurons,Abnormal phosphorylation of tau protein,vs,16,Beta amyloid (blue curve
9、) and Tau protein (orange curve) Research papers published in recent 30 years,17,Treatment,increase the concentration of acetylcholine (Ach) in the brain promoting survival of cholinergic neurons in the brain or improving their nerve conduction function reducing the production or promoting degradation of beta amyloid,18,Other,4,19,Still Alice,Film,The film tells the story of Alice Howland in seriously AD but still strong and brave . The film won the eighty-seventh Oscar award,20,The Notebook,Memories of Tomorrow,21,Thankyou,
