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1、b-吡啶 pyridine 巴比妥酸:barbituric acid 比电导conductance不规则的:irregular 崩解剂disintegrantc-萃取 extraction 成团:agglomeration 测量仪measurement 肠液:intestinal fluidd-胆固醇cholestero 对映体:enantiomer 电极electrode 代谢:metabolismf-反相渗透reverse osmosis 分布:dispositiong-构象:conformation 固化:solidizej-甲苯 toluene 静脉注:intravenous inje
2、ction 挤压:compress 聚集:aggregate 胶囊capsulel-粒子:particle 立体选择性:stereoselectivity 利用率:availability m-灭菌产品sterile products n-粘合剂adhesivep-偏振光:polarized light 片剂tablet 配剂elixir 排泄:excretionq-起始原料starting materials(raw materials) q醛 aldehyde r-溶解度:solubility 乳剂emulsion 润滑剂lubricants-释放:release 渗液solution 生
3、物膜:biologic membrane 生物碱alkaloid, t-糖浆syrup 甜味剂sweetenerw-丸剂pill 微生物microorganism 胃液:gastric fluid 稳定态:steady-state x-旋光异构现象:optical isomerism 悬浮液suspension 香味剂flavor 稀释剂diluent 形状:shape 吸收:absorption 消除:elimination y-胰岛素 insulin 压片:tablet compression z-中间体intermediate 重结晶 recrystallization 左旋:levor
4、otation 蒸馏distillation 组织tissue a-asymmetric carbon不对称碳 absorption吸收 action动作 adhesive粘合剂c-contamination污染 chirality:手性 compress压缩 composite合成的 compressibility:可压缩性 compaction:压紧 contamination specialize特殊污染 conductivity电导率 control:控制 clinical:临床的d- design:设计 dry:干燥 delivery:传送e- extend:延长 epoxide:环
5、氧化物f- formulation:制剂 fluidity:流动性 function:功能 g- geometric isomerism:几何异构h- hormone激素 hydrolysis diastereoisomer:水解非对映异构体heterogeneous catalyst多相催化剂， i- irrigating冲洗 m- metabolite代谢物 medication药物治疗 medicine内服药 mill:研磨measure尺寸 mix:混合 microorganisms微生物 o- ophthalmic眼药p- polysaccharide多糖 peptide肽 plas
6、ma血浆 penicillin青霉素， precursor:前体 partition coefficient:狭义分配系数 pharmaceutical制药的 parenteral注射药物 pycogens热源 procedure:程序 q- quality性质 quantity数量 s- steroid甾类 steric effect:空间效应 stereoselectivity:立体选择性screening:过筛 sustain :维持t- treat治疗 therapy:治疗 u-uniformity目标 v-vaccine疫苗Unit1 P7Answer the following q
7、uestions:How many groups can pharmaceutical agents be split into depending on their production or origin?totally synthetic materials(synthetics)natural productsproducts from partial syntheses(semi-synthetic products) (2)Can you illustrate any significant examples of pharmaceutical agents obtained by
8、 total synthesis? L-amine,chleramphomical,caffeine,Dopamine,Epinephrine, Lerodapa,peptide,hormones.Prestaglanding,P_Pouricollamine,Vincamine,(3)What is the difference between the synthetic drugs and traditional Chinese herbal medicine? synthetic drugs include the most important of synthetics and sem
9、i-sythetic products, however, natural products are frequently needed as starting materials or intermediates for important synthetic products. 2、生物碱4、Introduction of Nucleic acidsNucleic acids are polyanionic molecules of high molecular weight. These polymers are composed of a sequence of subunits or
10、 nucleotides so that the whole is usually termed a polynucleotide. The nucleic acids are of two main varieties, ribonucleic (RNA) and deoxyribonucleic (DNA). DNA is found primarily in the chromatin to the cell nucleus, whereas 90% of RNA is presented in the cell cytoplasm and 10% in the nucleolus. T
11、he two classes of nucleic acids are distinguished primary on basis of the five-carbon atom sugar of pentose present. Two general kinds of bases are found in all nucleic acids. One type is a derivative of the parent compound purine. Principle examples are guanine and adenine. The second class of base
12、s found in all nucleic acid is derived from the parent compound pyrimidine. 介绍核酸核酸是超高分子量聚阴离子分子。这些聚合物组成，亚基或核苷酸，使整个通常称为多核苷酸序列。核酸有两种，主要品种核糖核酸（RNA）和脱氧核糖核酸（DNA）的。 DNA是主要存在于细胞核内的染色质，而90的RNA在细胞质现在和10的核仁。核酸类的两个主要的区别在于对目前的五个戊糖碳原子的糖基础。一般两个种基地发现，在所有核酸。一类是母体化合物嘌呤的衍生物。原理是鸟嘌呤和腺嘌呤的例子。在所有发现核酸碱基第二类是来自母体化合物嘧啶。Unit2 P
13、231、Answer the following questions:(1) What is quantitative structure-activity relationship (QSAR) of pharmacologic agents?quantitative descriptions of physical properties of compounds and the response of the biological system under consideration.How many steric factors influence on the pharmacologi
14、c activity?Three major headings.(1)Optical and Geometric Isomerism and Pharmacologic Activity.(2)Confrontational Isomerism and Pharmacologic Activity.(3)Isomerism and Pharmacologic Activity.Why do enantiomophric pairs (optical isomers) exhibit different biological activities？difference in biologic a
15、ctivity may be due to a difference in the distribution of the isomers or to a difference in the properties of the drug-receptor combination of less them the optimal number of binding groups is suitably located for binding.2、静脉注射4、The finding of a novel drug molecule is a long, expensive, and tortuous process with no gua
