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1、 鶯 HCH 1 2 3 4 5 6 1825M 1942湦 1912vander 1946 1951 1952 6070 BHC12 16 99 DDT AcuteTox Mouse oral 78mg kg LD50 Mutagenicity Negative Tumorigenicity Mouse oral 0 250ppmindietfor24wkbeginningat28dofage studyduration 26wk RTECS EquivocaltumorigenicagentbyRTECScriteria Tumorigenic Facilitatesa
2、ctionofknowncarcinogen TumorigenicTumors Liver OtherMult Doses Rat oral 18mg kg 15D C TDLo Catalases Enzymeinhibition induction orchangeinbloodortissuelevels Biochemical Hepaticmicrosomaloxidase Enzymeinhibition induction orchangeinbloodortissuelevels Biochemical 仯 Otheroxidoreductases Enzymeinhibit
3、ion induction orchangeinbloodortissuelevels Biochemical AcuteTox Mouse intraperitoneal 5000ug kg TDLo Estrogenic Tumorigenicity Mouse oral 200mg kgindietRTECS EquivocaltumorigenicagentbyRTECScriteria TumorigenicTumors Liver Reprod Effects Mouse subcutaneous 100mg kg 7Dpre TDLo Uterus cervix vagina O
4、therMult Doses Mouse oral 9gm kg 30D C TDLo仯 Changesinothercellcount unspecified Blood任 Changesinspleenweight Endocrine İ Decreaseincellularimmuneresponse ImmunologicalIncludingAllergic AcuteTox Rat intraperitoneal 50mg kg TDLo仯 Changesinserumcomposition e g TP bilirubincholesterol Mutagenicity Posi
5、tive Tumorigenicity Mouse oral 400mg kgindietRTECS EquivocaltumorigenicagentbyRTECScriteria Reprod Effects Mouse oral 44mg kg 6 12Dpreg TDLo Fetotoxicity exceptdeath e g stuntedfetus OtherMult Doses Mouse oral 28 56mg kg 4W I TDLo仯 Changesinadrenalweight AcuteTox Chicken oral 597mg kg LD50 Ataxia Mu
6、tagenicity Rat oral 875mg kg 7W IPositive Tumorigenicity Mouse oral 800mg kg 80W I TDRTECS EquivocaltumorigenicagentbyRTECScriteria Reprod Effects Mouse oral 5460mg kg 91Dmale TDLo 侫 Testes epididymis spermduct OtherMult Doses Rat oral 350mg kg 2W I TDLo Lipids includingtransport 鴤 쪿
7、6; DavidowTrawley HCH HCH30 HCH6 HCH12 HCH 80 20 鶯 HCH HCH HCH Davidow HCH 3 HCH14 HCH 1 trichloro phenol 2 glutathione glycin glutamine Dichlorophenylmercapturicacid 8815 90 弰 71 PPCH HCH HCH12 HCH HCH HCH HCH HCH HCH HCH 1 HCH HCH 1 HCH 2 HCH2 1 HCH HCHClostridiumsphenoidesUQM780 HCH 3 4 5 6 ClostridiumrectumS 17 HCH 3 4 5 6 Citrobacterfreumdi Clostridiumsp Bacillussp HCH HCH 2 2 HCH HCH SphingomonaspaucimobilisUT2612 HCH HCHUT26 HCH2 5 2 5 HCH
