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1、Jaundice(黄疸),Department of Gastroenterology, First Affiliated Hospital of Chongqing Medical University,Jaundice or icterus : What is jaundice ? Clinically it is the yellow discoloration of the Sclera (巩膜) Skin Mucous membrane due to deposition of bile pigment (bilirubin胆红素) Serum total bilirubin (no
2、rmal 1.7-17.1 umol/lit ) Conjugated bilirubin:0-3.42mol/l， Unconjugated bilirubin:1.7-13.68mol/l.,1. DEFINITION,2. BILIRUBIN METABNISM,Heme Degradation,HEME,BILIVERDIN,O2,Fe+3,(opens the porphyrin ring),BILIRUBIN,BILIRUBIN diglucuronide,BILE,The Fate of Bilirubin,Alb = albumin B = bilirubin GST = gl
3、utathione-S-transferase UDPGA = uridine diphosphoglucuronic acid; CB = conjugated bilirubin UGT1A1 = UDP-glucuronosyltransferase 1A1 MRP2 = Multi-drug Resistance Protein 2 Adapted from Harrisons 15th Ed. “Principles of Internal Medicine”, 2001.,MRP2,CB,Plasma,Hepatic Cell,Bile,sER,B,+ UDPGA,UGT1A1,B
4、ilirubin Excretion,Intestines,Liver,B,CB,CB,B,Urobilinogen,B-glucoronidase,bacteria,bacteria,Bile,Enterohepatic circulation,Kidney,Urobilin,ox,Urobilinogen,Urobilin,Stercobilin,Stercobilingogen,Urine,ox,Liver,Albunin,Heme,Ferroheme,transferase,Bilirubin,Conjugated bilirubin,Kidney,Urobilin,Stercobil
5、inogen,Urobilinogen,Intestines,Albumin,Bilirubin,reductase,Heme,Globin,Hemoglobin,oxidase,Biliverdin,Marrow,Infantility Erythrocyte Ferroheme Enzyme 15%20%,Bilirubin | Albumin,Erythrocyte 80%85%,UDP,UDPGA,Bilirubin glucuronolactone,urobilinogen,Enterohepatic circulation,Y/Z protein,cathepsin,Erythro
6、cyte,Biochemical change of Normal bilirubin metabolism,3. CLASSFICATION,1. Depending on Etiology Hemolytic Jaundice （溶血性黄疸） Hepatocellular Jaundice（肝细胞性黄疸） Cholestatic Jaundice（胆汁淤积性黄疸） Congenital jaundice （先天性黄疸）,2. Depending on bilirubin Unconjungated bilirubin increased jaundice Conjungated bilir
7、ubin increased jaundice,Etiology 1.Congenital hemolytic anemia (thalassemia(海洋性贫血),hereditary spherocytosis(遗传性球形红细胞增多症). 2.Posteriority acquired hemolytic anemia (autoimmunity hemolytic anemia, hemolytic disease of newborn, posttransfusion hemolytic, Favism(蚕豆病). Mechanism A large number of erythro
8、cyte destroyed rapidly Anemia,hypoxia and toxity of erythocyte metabolism products,3.1. Hemolytic Jaundice,Hemolytic Jaundice mechanism,Clinical Manifestation Mild jaundice, light lemon, no skin itch(痒). Acute hemolysis: fever, chill, headache, vomit, backache, anemia, hemoglobinuria(血红蛋白尿), acute r
9、enal failure. Chronic hemolysis: anemia and splenomegaly(脾大).,Laboratory Examination 1.Serum TB,UCB,CB normal. 2.UCBintestinal CBfaecal color deepen. 3.Intestinal Urobilinogen(尿胆原)urinary Urobilinogen. 4.Acute hemolytis, occult blood test (+). 5.Blood test: anemia, reticulocyte(网织红细胞), erythrocyte p
10、roliferation.,3.2. Hepatocellular Jaundice,Etiology Hepatocyte damage. Mechanism Impair hepatocyte uptakeing, conjugating and excreting bilirubin, UCB CB reflux into blood, serum CBjaundice.,Hepatocellular Jaundice mechanism,Clinical Manifestation Skin and mucosa: light to deep yellow, mild skin itc
11、h(痒) Tired, loss of appetite hemorrhagic tendency, ascites, coma. Primary disease manifestation,Laboratory Examination CB, UCB Icteric hepatitis: CB UCB Urine: CB(+),urobilinogen Blood test: liver damaged,3.3. Cholestatic Jaundice,Etiology Obstruction in liver:virus hepatitis,drug caused,drug hepati
12、tis, primary biliary cirrhosis. Obstruction of Extrahepatic bile duct:narrow, obstruction,stone, inflammtory,tumor. Mechanism Obstruction causes small bile duct and bile capillary broken, conjugated bilirubin reflux to blood. Failure of hepatocyte excreting CB,bilirubin deposit and bile thrombus(胆栓)
13、 formation.,Cholestatic Jaundice mechanism,Clinical Manifestation Skin dark yellow, yellow green. Skin itch (痒), bradycardia (心动过缓), dark yellow of urine, faecal light yellow or clay color. Courvoisiers sign.,Laboratory Examination Serum CB Urine bilirubin (+) Urobilinogen , stercobilin(粪胆原) or abse
14、nce Serum alkaline phosphatase and Cholesterol(胆固醇),5. Genetic Disorders of Bilirubin Metabolism,Rotors syndrome deficiency of uptaking UCB and excreting CB, CB jaundice.,Crigler-Najjar syndrome Gilberts syndrome,Three kinds of jaundice laborotory examination indentification,Class Hemolytic Hepatoce
15、llular Cholestatic TB increased increased increased CB normal increased markedly increased CB/TB 15一20 30一40 50一60 urine bilirubin 十 十十 urobilinogen increased slight increased decreased or absence ALT、AST normal markedly increased may increased ALP normal increased markedly increased r-GT normal increased markedly increased PT normal delayed delayed Vit K respond no poor good Cholester
