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1、General presentation 介介绍Stress management through nutrition 减压2IDI OverviewIDI Overview公司概述公司概述公司概述公司概述Turnover: 235m 营业额：2.3亿欧元Export sales: 70% 出口销售额：70%Commercial presence in more than 120 counties 产品广销120个国家Annual production: 100,000MT of dairy ingredients 年生产量：10万吨乳制品Range of products: dairy po
2、wders, functional systems, milk proteins 产品范围：乳制品，功能性食品原料，乳蛋白3Introduction 简介介 Scientific evidence 科学依据科学依据Regulatory status 法法规现状状Technological data 技技术数据数据Marketing potential 潜在市潜在市场Conclusion 结论Table of contentsTable of contents目目目目录录June 2008Introduction 简介介5IntroductionWhat is stress ?What is s
3、tress ?压压力是什么？力是什么？力是什么？力是什么？“ Without stress there would be no life” Hans Selye 压力无处不在Stress is not a disease but a stimulus. It is an unavoidable natural reaction of the body and the mind to everyday tension and pressure. 压力并不是一种病而是对人的一种刺激，它是对人体、人脑的紧张状态不可避免的一种自然反应。Stress is both - universal: every
4、one is subject to stress 压力是普遍的：每个人都容易感觉有压力 - individual: people respond to stress in different ways. 压力又是个别的：人们对待压力的反应各不相同When stress is not well-managed, instability is generated and stress-related disorders appear. 当压力没有得到很好的控制时，不稳定性将会产生，压力有关的失调紊乱也会出现。Consumers cannot or do not want to stop stres
5、s, but rather regulate its symptoms. 人们通常不可避免产生压力（或则希望有些压力），但希望可以调节它的症状。6Lactium was developed by Ingredia Nutritionals scientists, in collaboration with research institutes since 1990. 自1990年起， Lactium由Ingredia营养公司与研究所一起研发的。The baseline of this research was the simple observation of the calm state
6、of a baby after breastfeeding. 研究的基准是观察母乳喂养的婴儿的情绪状态。Researchers wanted to find a relationship between the consumption of milk and this soothing state. 研究者希望能找出饮用牛奶与平复情绪之间的关系。After many years of research and several clinical and toxicological studies, they succeeded in identifying within a milk prote
7、in, a bio-peptide with natural relaxing properties, that can be isolated thanks to a typical hydrolysis. 经过多年的研究、若干次临床试验和毒理性试验，他们成功的鉴定了在牛奶蛋白中天然十缩氨酸（是一种孤立的水解蛋白）具有减压（令人心情放松）的生理活性。How a baby discovered LactiumHow a baby discovered Lactium Lactium Lactium 是如何被是如何被是如何被是如何被婴婴儿儿儿儿发现发现的的的的Introduction7Lacti
8、um is a milk protein hydrolysate that contains a bioactive decapeptide with relaxing properties. Lactium是牛奶蛋白的水解产物，它包含了具有生物活性的十缩氨酸，其具有令人放松的作用。The adult enzymatic system cannot release this bioactive peptide anymore. That is why taking Lactium is the natural solution to calm down. 由于成人体内的酶系统不能释放出具有生物
9、活性的十缩氨酸，就是为什么服用 Lactium是一种让人减压的天然方法。Lactium has been clinically proven to be efficient on stress symptoms reduction. Lactium拥有临床研究证明其对减轻压力上具有功效。Lactium does not suppress stress factors 并非是抑制压力产生but it decreases stress-related symptoms 而是减轻与压力有关的症状and helps cope with occasional and everyday stress. 也
10、是帮助您面对偶然或每天的压力Lactium is a unique, natural and efficient solution to help consumers deal with stress-related symptoms.Conformation of the bioactive decapeptide(-casozepine)What is LactiumWhat is Lactium ? ?Introduction8How does LactiumHow does Lactium work ? work ?如何起效？如何起效？如何起效？如何起效？Lactiums action
11、: 起效起效Positioning on stress symptoms: prevention or improvement of: 对于于压力症状的定位：力症状的定位：预防防还是改善是改善Chronic pain due to chronic stress长期病痛导致长期性压力Sleep disorders睡眠失调Digestive disordersdue to occasional stress食欲不调导致偶然性压力Mood disorders情绪失控Impaired memory &concentration记忆力或注意力下降Relationship troubles e.g. li
12、bido decrease相关性困扰如：性欲下降Weight management体重控制State of tension e.g. quit smoking紧张如：戒烟STRESS RELEASE压力的释放Occasional stress: exams, diet,偶然性压力：考试，节食Chronic stress: everyday life长期性压力：日常生活中Introduction9Lactium is one of the few ingredients that have received a French health claim authorization from the
13、 French Safety and Control Administration DGCCRF (French General Directorate for Competition Policy, Consumer Affairs and Fraud Control) approved by the AFSSA (French Food Safety Agency): Lactium是少数通过了法国安全控制监督局健康认证的一个食品原料（法国：竞争、消费和抑制欺诈总理事会食品管制） peut modrer la rponse tensionnelle au stress, notamment
14、 chez les personnes particulirement sensibles . can moderate the tensional response to stress, in particular for hypersensitive persons. 它可以平复由压力产生的紧张情绪，特别是对于过分敏感的人群.Moreover, Lactium is on the EHPM/CIAA list, waiting to receive a European health claim authorization from the EFSA (European Food Safe
15、ty Agency) in 2010 (EEC Regulation 1924/2006 art. 13). As it is considered level 5, Lactium has the highest chances of receiving this European health claim authorization. 而且，已在LactiumEHPM/CIAA名单中（等待EFSA欧洲食品安全局的健康认证），在此名单中Lactium是最有希望通过认证的。Lactium also benefits from a Korean health claim authorizatio
16、n: Lactium通过了韩国的健康认证Milk hydrolysate (Lactium) can release the tension by stressAustralian TGA authorization 澳大利澳大利亚治治疗用品管理局用品管理局认证LactiumLactium : acknowledged efficacy: acknowledged efficacy功效被承功效被承功效被承功效被承认认IntroductionJune 2008Scientific evidence科学依据科学依据11Scientific evidenceLactiumLactium : prov
17、en efficacy on humans: proven efficacy on humans人体人体人体人体实验证实验证明有效性明有效性明有效性明有效性6 clinical studies carried out on 234 volunteers通通过了了6次次临床研究（床研究（234名志愿者）名志愿者）All clinical trials were performed according to Good Clinical Practices Guidelines and under official ethical committees scrutiny. They were all
18、 performed on healthy human volunteers, using validated biological indicators and randomized, double-blind and placebo-controlled procedures.Necker Hospital, 1999: 1999年年Necker医院医院9 volunteers 9名志愿者150 to 1250mg of Lactium as a single oral intake 一次性服用150-1250mg Lactium1 day period 1天Optimed, 1999:
19、1999年年Optimed24 volunteers (12 males + 12 females) 20 to 35 years old 20-35岁的24名志愿者（男女各12名）150mg of Lactium as a daily oral intake 每日口服150mg Lactium15 days period 15天Necker Hospital, 2000: 2000年年Necker医院医院42 male volunteers 18 to 35 years old 42名男性志愿者（18-35岁）2 x 400mg of Lactium the first day and 1
20、x 400mg of Lactium the second day 第一天口服2次每次400mg Lactium ，第二天口服1次400mg Lactium2 days period 2天12Scientific evidenceCRSSA, 2001:52 volunteers (25 males + 27 females) 18 to 40 years old 52 名志愿者 （年龄18-40岁，25名男性27名女性 ）150mg of Lactium as a daily oral intake 每日口服150mg Lactium30 days period + 12 days wash
21、-out 服用30天，后12停止服用 Proclaim, 2003: 63 female volunteers 18 to 61 years old 63名女性志愿者 年龄18-61岁150mg of Lactium as a daily oral intake 日口服150mg Lactium30 days cross-over + 3 weeks wash-out 30天交叉服用，后3周停止服用IGHD, 2006:44 mixed volunteers 25 to 40 years old 44名志愿者-年龄25-40岁150mg of Lactium as a daily oral i
22、ntake 每日口服150mg Lactium4 weeks period + 1 week wash-out 连续4周，后1周停止服用LactiumLactium : proven efficacy on humans: proven efficacy on humans人体人体人体人体实验证实验证明有效性明有效性明有效性明有效性13Scientific evidence1. Evaluation of Lactium effect on basal metabolism and side effects at different dosages. Necker Hospital, 1999
23、. 评估服用不同估服用不同剂量的量的Lactium在人体中的新在人体中的新陈代代谢及其副作用。及其副作用。(150 to 1250mg of Lactium administered p.o. 1 day - 9 volunteers)（1天服用150-1250mgLactium-9名志愿者）Lactium has no side effects on humans even at high dosages (1250mg). 证明即使在服用很高剂量（1250mg）的Lactium对人体无副作用。2. Evaluation of Lactium anti-stress effect. Opti
24、med, 1999. 评估的估的Lactium抗抗压作用作用(150mg of Lactium p.o. 15 days 24 volunteers) - Stress induced by stroop test. （ 15天服用150mgLactium-24名志愿者）-通过实验诱发压力Lactium decreases the anxiety-state score. Lactium可以减可以减轻焦焦虑状状态LactiumLactium : proven efficacy on humans: proven efficacy on humans人体人体人体人体实验证实验证明有效性明有效性明
25、有效性明有效性143. Lactium anti-stress effect in a short-time study. Necker Hospital, 2000. 研究研究Lactium短期内短期内对于抗于抗压的效果的效果 (Lactium p.o. - 1st day: 400mg x 2, 2nd day: 400mg x 1 42 volunteers) - Stroop test. （第一天服用2次每次400mg，第二天服用1次每次400mg-42名志愿者） Lactium significantly moderates the SBP (-31.9% vs. placebo),
26、 DBP (-28.9% vs. placebo) and blood cortisol response to stress (-21.3% after 3h). Lactium有效地调节了收缩压SBP(-31.9% 比空白组)、舒张压DBP (-28.9%比空白组)和血液中的皮质醇(服用后3小时下降21.3% )*Unpaired t-test (2 tailed) * p 0.01 * p 0.05 -31.9%-28.99%Scientific evidencePaired t-test (2 tailed): * p 2000mg/kg. 急性毒性实验（按每公斤体重服用2000mg，
27、相当于有效剂量的130倍-1天）， Lactium的半数致死率大于2000mg/kg。Sub-chronic (40, 200 and 1000mg/kg - 28 days) and chronic toxicity (40, 250 and 1000mg/kg - 91 days): no observable toxic effects even at 1000mg/kg/d. 潜在的长期性毒性（按每公斤体重服用40，200，1000mg-28天），长期性毒性（按每公斤体重服用40，250，1000mg-91天）：观察表明即使在高剂量下也无毒性。Further studies 进一步研究
28、一步研究No mutagenicity: no mutagenic effect observed in vitro in mammalian cells, either with or without metabolic activity. 无诱变性：体外哺乳动物细胞实验No teratogenicity (15mg/kg p.o. - all gestation long): neither general nor visceral malformation in young rats. 无致畸性（孕期中服用剂量每公斤体重15mg）No behavioral toxicity (15mg/
29、kg p.o. - all gestation long): neither change in gestating rats, nor alteration in the development of their broods. 无行为毒性（孕期中服用剂量每公斤体重15mg ）Scientific evidence23and no side effectsand no side effects无副作用无副作用无副作用无副作用p.o. administration of Lactium on rats showed 动物实验:No memory loss (Social memory test
30、) 记忆损伤No habituation (Conditioned defensive burying test (CDB) 无依赖性No addiction (Conditioned place preference test) 无上瘾性No sedation (No weight increase i.e. no decrease of physical activity) 无镇静（不增加体重，不减少体能活动）No disinhibition (CDB and Elevated plus maze (EPM) models) 无去抑制Neither psychological nor so
31、matic side effects tested on rats and confirmed on humans through the Hopkins symptom checklist. 动物（老鼠）实验表明无心理或生理上的副作用，人体通过贺普金斯症状检核表Neither loss of alertness nor muscular reactivity tested on rats and confirmed on humans through the Thayer questionnaire. 动物（老鼠）实验表明无肌肉性反应，人体通过赛耶调查Lactium is a milk pr
32、otein hydrolysate so it is hypoallergenic. It contains little lactose (1%) and therefore presents low risks of lactose intolerance. 它是水解牛奶蛋白，低变应原。含有少量乳糖（小于1%），出现乳糖不耐症的几率较小Lactium shows no toxicity and no side effects.Scientific evidenceRegulatory status法法规现状状25Efficacy recognized by Authorities 权威威认
33、可可Lactium is one of the few ingredients that have received a French health claim authorization from the French Safety and Control Administration DGCCRF, approved by the AFSSA: Lactium是少数通过了法国安全控制监督局健康认证的一个食品原料 can moderate the tensional response to stress, in particular for hypertensive persons.More
34、over, Lactium is on the EHPM/CIAA list (level 5), waiting to receive a European health claim authorization from the EFSA in 2010.而且，已在LactiumEHPM/CIAA名单中（等待EFSA欧洲食品安全局的健康认证），在此名单中Lactium是最有希望通过认证的。Lactium also benefits from a Korean health claim authorization: Lactium通过了韩国的健康认证Milk hydrolysate (Lact
35、ium) can release the tension by stressAustralian TGA authorization 澳大利亚治疗用品管理局认证A food grade ingredient 食品食品级原料原料Europe: not classified as Novel food USA: - GRAS (Generally Recognized As Safe公认无毒) status, FDA approved (peptone category蛋白目录) - NDI (New Dietary Ingredient新膳食原料) approved (# rpt242)A cl
36、ean label 清晰的清晰的标签Europe and Asia: milk protein hydrolysate 水解乳蛋白USA: caseinhydrolysate 水解酪蛋白 Regulatory statusLactiumLactium : a clear and well-defined : a clear and well-defined regulatory statusregulatory status Lactium Lactium : :清晰准确的法清晰准确的法清晰准确的法清晰准确的法规现规现状状状状26Worldwide patentsWorldwide paten
37、ts世界世界世界世界专专利利利利Ingredia Nutritional owns a patent on the decapeptide and its activity, including products containing it:Ingredia营养公司拥有十缩氨酸与产品的专利European title = Utilisation dun dcapeptide activit de type benzodiazpine pour la prparation de mdicaments et de complments alimentaires (Use of a decapept
38、ide with a benzodiazepine activity for the preparation of medicaments and dietary suplements), EP 0714910B1, Nov. 30, 1995.US title = Use of a decapeptide with benzodiazepine-type activity for preparing medicines and food supplements, Patent Number 5,846,939, Dec. 8, 1998.Japan title = Use of a deca
39、peptide with benzodiazepine-type activity for preparing medicines, Patent Number 3973244, June 22, 2007. Regulatory status27and awardsand awards荣誉荣誉荣誉荣誉 Regulatory statusJune 2008Technological data技技术数据数据29Lactium Casein hydrolysate containinga bioactive decapeptide酪蛋白水解物包含了生物活性的十缩氨酸s1 casein 酪蛋白酪蛋白
40、Skimmed milk 脱脂奶脱脂奶protein separation蛋白分离tryptic hydrolysis + heat treatment + dryingPeptideBioactive peptide Technological dataLactiumLactium : a food grade process: a food grade processLactium is a milk protein hydrolysate containing a bioactive decapeptide that results from an enzymatic digestion
41、 similar to the babys one.30Ingredia S.A. is ISO 9001:2000 certifiedand has been following HACCP guidelines since 1992.Each batch is controlled. Tests ensure a standardized, homogenous and safe content by 每批监控，实验确保标准化，质量稳定，安全: Physical analysis (color, taste, ) 物理检测（颜色，味道）Chemical analysis (moisture
42、, fat, protein, ) 化学检测（水分，脂肪，蛋白质）Microbiological analysis (E. Coli, Salmonella, ) 微生物检测（大肠杆菌，沙门氏菌）Nutritional analysis (energy value, minerals, amino acid, ) 营养成分检测（能量，矿物质，氨基酸）The bioactivity of Lactium is validated on each batch through 2 methods: 每批产品通过2个方法证明其生物活性HPLC (High Performance Liquid Chro
43、matography): to quantify and guarantee the active ingredient content. HPLC：检测活性成分含量CDB (Conditioned Defensive Burying standardized test on rats): to control the biological activity of Lactium in vivo.in vivo. 条件型条件型电电极包埋模型（老鼠极包埋模型（老鼠实验实验）：）：检测检测体外生物活性体外生物活性a aS1- CN (f91-100)LactiumLactium : a contr
44、olled process for : a controlled process for guaranteed qualityguaranteed quality 全程全程全程全程监监控确保控确保控确保控确保质质量量量量 Technological data31Developed to be easily incorporated in food or dietary supplements. 容易在食品和膳食补充中应用Several references adapted to consumers needs. 多种文献支持Water-soluble at the recommended do
45、sage. 水溶（推荐使用剂量）pH-stable (from 2 to 9) and heat-stable. PH稳定（2-9），热稳定No off-flavor in applications (no bitterness). 无不良气味，无苦味Perfectly adapted and effective in different food matrices: 可运用于多种食品形式Functional foods: 功能性食品Dairy products Fermented milk Biscuits Beverage Chocolate Cereal bars 乳制品 发酵乳 饼干
46、饮料 巧克力 谷物棒Dietary supplements: 膳食补充Capsules Softgels Tablets Sticks Gums 胶囊 软胶囊 片剂 棍状 凝胶Several applications already tested by Ingredia Nutritional (available on request). 多种形式已被运用Recommanded dosage 有效有效剂量量: 150mg/dayFor a minimum program of 2 weeks, ideally 1 month + additional dose during acute st
47、ress period.连续2周，特别情况下1个月，也可加大剂量LactiumLactium : flexible in applications: flexible in applications易于易于易于易于应应用用用用 Technological dataJune 2008Marketing potential潜在市潜在市场33ZenZen& &SlimSlim For a diet without snacking or bad mood.For a diet without snacking or bad mood. Lactium supports you during your
48、 diet by helping better manage your stress to control food craving.帮助你控制由压力引起的食欲增加Marketing potentialLactiumLactium : successful in applications*: successful in applications*成功案例成功案例成功案例成功案例Good nightsGood nights Refreshing nights make effective days.Refreshing nights make effective days. Thanks to
49、Lactium, you can improve your sleep quality and length. More relaxed and alert in the morning, you feel ready for a busy and challenging day.优质睡眠确保你每日精神气爽、高效生活可以改善你的睡眠质量，延长睡眠。让你第二天神清气爽，充满活力的迎接挑战。*These concepts and recipes are indicative information. They have no legal status. They are suggested wit
50、hout guarantee of compliance with country regulations. 34LactiumLactium : successful in applications*: successful in applications*成功案例成功案例成功案例成功案例Easy detox Easy detox No has never been so easy to say.No has never been so easy to say. Tobacco detoxification is a nerve-racking stage of life. Lactium
51、can help you successfully quit smoking by limiting stress and boosting your motivation.当你为了戒烟而扰乱了你的日常生活， Lactium可以帮助你成功戒烟，并且减少你由戒烟引起的不安，使你充满活力。Choco Relax Choco Relax Your mood solution.Your mood solution. When life pressure reaches your emotional balance, Lactium appears as an ideal solution to rec
52、over peace and wellness.巧克力可以让你放松心情。当生活的压力超出了你的承受范围， Lactium是帮你恢复平静与健康的理想的选择。35Clear Mind Clear Mind Clarify your mind in serenity.Clarify your mind in serenity. Lactium decreases the negative effects of stress upon intellectual functioning, especially during highly demanding periods.让你保持头脑清新。 Lacti
53、um可以减少因为压力而产生的负面影响。Yog CoolYog Cool Recover your serenity and stand back from everyday Recover your serenity and stand back from everyday stress.stress. Every morning, you feel tense because of your active way of life. Lactium helps you relax and preserves your quality of life.让你从每日的压力中恢复平静。由于白天工作或生
54、活的压力让你时常在晚上都感觉紧张， Lactium可以帮助你放松，保证你的生活质量。Marketing potential*These concepts and recipes are indicative information. They have no legal status. They are suggested without guarantee of compliance with country regulations. LactiumLactium : successful in applications*: successful in applications*成功案例成功
55、案例成功案例成功案例36PleasurePleasure& &Harmony Harmony Recover your desire.Recover your desire. Stress can make you experience a lack of libido. Lactium acts to diminish the symptoms brought on by stress, including decreased libido.快乐&和谐，压力使你性欲下降。 Lactium可以减少由压力引起的此类症状。RelaxactionRelaxaction And your tensio
56、n melts away. And your tension melts away. Lactium helps you better cope with stress due to stressful situations.融化你紧张的情绪。 Lactium可以帮助你很好的处理由于压力引起的紧张情绪。LactiumLactium : successful in applications*: successful in applications*成功案例成功案例成功案例成功案例June 2008Conclusion总结38Lactium: a unique innovative and pat
57、ented natural bioactive ingredient resulting from more than 10 years of research. Lactium：是一个独一无二的创新产品天然的生物活性成分（通过10年的研究）。Efficacy proven by clinical studies on stress-related symptoms. 临床研究证明其对由压力引起的相关症状有效。Claim authorization from the French Safety and Control Administration (DGCCRF): 法国安全控制监督局健康认证
58、 can moderate the tensional response to stress, in particular for hypertensive persons.它可以平复由压力产生的紧张情绪，特别是对于过分敏感的人群.No side effects, total safety. 无副作用，安全。Clean label. 宣称Easy incorporation in food or dietary supplements. 易于在食品和膳食补充剂中运用。Strong partnership between Ingredia Nutritional and its customer
59、s for successful end products. Ingredia营养公司与消费者之间紧密合作。When choosing Lactium, you embrace a breakthrough innovation that takes you one step ahead of competing products.当你当你选择了了Lactium，就，就等于等于选择了一个独一无二的了一个独一无二的创新新产品，品，领先于其他先于其他竞争品牌。争品牌。ConclusionConclusion Conclusion 总结总结39More than a supplier of revo
60、lutionary nutritional ingredients, Ingredia Nutritional is a partner that will contribute to the success of your products.Scientific, Technological, Marketing & Regulatory Support: 拥有科学、技有科学、技术、市、市场和法和法规的支持：的支持：Original concepts and advice for recipes including Lactium.独创的概念并且在处方上提供建议。Customized pro
61、duct co-development and matrix efficacy tests. 共同合作发展，为你提供着身定制产品和功效实验。On demand customized tests and clinical studies to validate the effectiveness of your product formulated with Lactium.提供专门的实验和临床研究来证明你们产品（含有Lactium）的有效性。Positioning advice for end products containing Lactium.提供最终产品Lactium的建议添加量。In
62、gredia Nutritional: a reliable partnerIngredia Nutritional: a reliable partnerIngrediaIngredia营营养公司是一个可靠的合作伙伴养公司是一个可靠的合作伙伴养公司是一个可靠的合作伙伴养公司是一个可靠的合作伙伴ConclusionMore than a supplier of revolutionary nutritional ingredients, Ingredia Nutritional is a partner that will contribute to the success of your p
63、roducts.Scientific, Technological, Marketing & Regulatory Support: 拥有科学、技有科学、技术、市、市场和法和法规的支持：的支持：Co-branding program by using Lactium trademark and logo on your packaging, bringing credibility to your end products.Ingredia Nutritional ensures Lactium reputation through a general public communication
64、. 品牌共享： 可以在最终产品中使用Lactium商标和 ，来增加产品的可信度。Ingredia营养公司保证产品的公众信誉度。Scientific documentation available to build clear, consistent and positive messages for consumers.拥有科学文献的支持，和消费者的一贯支持与积极的反馈。Support during the claim process to help its validation.对于产品宣称提供有效证明。Information about labeling recommendations a
65、nd customs regulations.提供推荐使用量和法规信息。40Ingredia Nutritional: a reliable partnerIngredia Nutritional: a reliable partnerIngrediaIngredia营营养公司是一个可靠的合作伙伴养公司是一个可靠的合作伙伴养公司是一个可靠的合作伙伴养公司是一个可靠的合作伙伴41ReferencesReferences参考文献参考文献参考文献参考文献Scientific publications(1) Lecouvey, M.; Frochot, C.; Miclo, L.; Orlewski,
66、 P.; Driou, A.; Linden, G.; Gaillard, J.-L.; Marraud, M.; Cung, M. T. and Vanderesse, R. (1997). Two-dimensionnal H-NMR and CD structural analysis in a micellar medium of a bovine s1-casein fragment having benzodiazepine-like properties. Eur. J. Biochem. 248, 872-878.(2) Lecouvey, M.; Frochot, C.; M
67、iclo, L.; Orlewski, P.; Marraud, M.; Gaillard, J.-L.; Cung, M. T. and Vanderesse, R. (1997). Conformational studies of a benzodiazepine-like peptide in SDS micelles by circular dichroism, H NMR and molecular dynamics simulation. Letters in Peptide Science, 4:359-364.(3) Miclo, L.; Perrin, E.; Driou,
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69、online. (4) Lanoir, D.; Canini, F.; Messaoudi, M.; Lefranc, C.; Demagny, B.; Martin, S. and Bourdon, L. (2002). Long term effects of a bovine milk alpha-S1 casein hydrolysate on healthy low and high stress responders. Stress, 5 (suppl.), 124.(5) Messaoudi, M.; Bresson, J.-L.; Desor, D.; Lefranc, C.;
70、 Boudier, J.-F. and Paquin, P. (2002). Anxiolytic-like effects of the milk protein hydrolysate Prodiet F200 in healthy human volunteers. Stress, 5 (suppl.), 124. (6) Schroeder, H.; Violle, N.; Messaoudi, M.; Lefranc-Millot, C.; Nejdi, A.; Demagny, B.; Desor, D. (2003). Effects of ING-911, a tryptic
71、hydrolysate from bovine milk aS1-casein on anxiety of Wistar male rats measured in the conditioned defensive burying paradigm and the elevated plus maze test. Behavioural Pharmacology, 14 (S1), S38, P3142ReferencesReferences参考文献参考文献参考文献参考文献(7) Messaoudi, M; Lefranc-Millot, C.; Desor, D.; Demagny, B.
72、; Bourdon, L. (2005). Effects of a tryptic hydrolysate from bovine milk alpha (S1)-casein on hemodynamic responses in healthy human volunteers facing successive mental and physical stress situations. Eur J Nutr. Mar; 44(2):128-32. Epub 2004 Nov2.(8) Guesdon, B.; Messaoudi, M.; Lefranc-Millot, C.; Fr
73、omentain, G.; Tom, D.; Even, P.C. (2006). A Tryptic Hydrolysate from Boviune milk -S1-casein improves sleep in rats sujected to chronic mild stress. Peptides, doi:1016/J. peptides. 2005.10.001.(9) Violle, N.; Messaoudi; M.; Lefranc-Millot, C.; Desor, D.; Nejdi, A.; Demagny, B.; Schroeder, H.; (2006)
74、. Ethological comparison of the effects of a bovine -S1-casein tryptic hydrolysate and diazepam on the behavior of rats in two models of anxiety. Pharmacology, Biochemistry and Behavior, 84(3), 517-523.(10) Kim, J.H.; Desor, D.; Kim, Y.T.; Yoon, W.J.; Kim, K.S.; Pyun, K.H. and Shim, I. (2006). Effic
75、acy of -S1- casein hydrolysate on stress-related symptoms in women. European Journal of Clinical Nutrition, 1-6.(11) Saint Hilaire, Z.; Messaoudin M.; Desorn D.; Kobayashi, T. (2008). Effects of a bovine s1-casein tryptic hydrolysate (CTH) on sleep disorder in japanese general population. The Open Sleep Journal, 2009, 2, 26-32.43Thank you for your attentionThank you for your
