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1、原发性肾脏肿瘤病理原发性肾脏肿瘤病理分类分类天马行空官方博客:http:/ ;QQ:1318241189;QQ群:175569632肾肿瘤种类很多,至今还没有一个统一的分类方法,根据肿瘤的来源,主要分为下列7类:1、来自肾实质的肿瘤,有肾腺瘤和肾癌(又称肾细胞癌); 2、来自肾盂上皮的肿瘤,有移行乳头状瘤、移行细胞癌、鳞形细胞癌和腺癌;3、来自肾胚胎组织的肿瘤,有肾母细胞瘤(即Wilms肿瘤)、胚胎癌和肉瘤;4、来自间叶组织的肿瘤,有纤维瘤、纤维肉瘤、脂肪肉瘤、平滑肌瘤;5、来自血管的肿瘤有血管瘤、淋巴瘤和错构瘤; 6、来自神经组织的肿瘤有神经母细胞瘤、交感神经母细胞瘤; 7、来自肾包膜的肿瘤
2、,有纤维瘤、平滑肌瘤、脂肪瘤、混合瘤;肾肿瘤大多为恶性,预后不良,病理复杂,临床表现不一,其中以肾细胞癌最为常见,其次为肾盂移行细胞癌和肾母细胞瘤。以下简单介绍常见的3类肾肿瘤的病理特点:天马行空官方博客:http:/ ;QQ:1318241189;QQ群:175569632(1) 肾细胞癌( renal cell carcinoma )组织发生:近端肾小管上皮细胞病理特点:位于肾皮质,切面黄色;富含透明胞浆的癌细胞呈巢索状排列。生物性特性:中老年好发;因血管丰富,可早期血行转移至肺、骨。CONCLUSIONRenal cell carcinoma: Histogenesis: proxima
3、l tubular cells. Morphology: clear-cancerous cells and trabecularism. Clinical features: renal neoplasm and hematuria occur in 60th and 70th decades of men. Behavior: malignant tumor, often hematogenous metastasis.组织发生:肾胚芽组织病理特点:肾内巨大肉瘤样肿块;由未分化的胚芽组织、间胚叶性间质和幼稚的肾小球和肾小管组成生物学特性:婴幼儿好发;早期血行转移至肺、肝等(2) 肾母细胞瘤
4、肾母细胞瘤( nephroblastoma, Wilm tumor )天马行空官方博客:http:/ ;QQ:1318241189;QQ群:175569632CONCLUSIONNephroblastoma (Wilms tumor): Histogenesis: renal blastem. Morphology: blastem tissue, abortive glomeruli and tubules, mesenchymal tissue. Clinical features: renal neoplasm and hematuria occur in 2-4 years child
5、hood. Behavior: malignant tumor, often hematogenous metastasis.(3)肾盂移行细胞癌组织发生: 移行上皮细胞病理特点: 移行上皮乳头状瘤: 与正常移行上皮相似的肿瘤组织呈乳头状伸出性生长。移行上皮癌: 有一定异型性的癌组织呈 伸出性和浸润性生长;依癌组织的异型性,分为I、II、III级生物学特性: 中老年好发;易复发;以局 部浸润和淋巴路转移常见CONCLUSIONUrothelial tumors: Histogenesis: transitional cells. Morphology: papilloma and variou
6、s grades carcinoma. Clinical features: hematuria occur in adult and old men. Behavior: benign papilloma easily recur and become malignant, transitional carcinoma which is often multi-focus growth, and progresisive infiltration, invasion and destruction of the surrounding tissue.KEY WORD: Renal cell carcinoma, Nephroblastoma, Urothelial tumors 谢谢!