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1、Cancer metastasisDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT What is metastasis?Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Cancer Stem Cells motivate and motivate and maintain the maintain the growth of growth of cancer cellscancer cellspotentialitypotentiality plasticityplasticity make them make t
2、hem easy to easy to survivesurviveHypothesis of tumor metastasisThe phases of Cancer metastasisThe mechanism of cancer metastasisMalignant Tumor metastasis pathway The molecules in the metastasis The phasesphases of Cancer metastasis俞仁涛Invasion(侵犯)Intravasation（内渗）Extravasation（外渗）Designer:S.G.C.che
3、n8332海. 水. 正. 蓝. 作. 品NEXT Invasion1.Stable cell movable cell 2.Protein expression3.Movement mechanismRelative genesDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Intravasation1.Angiogenesis 2.Immune escape Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Extravasa
4、tionThe inverse process of invasionTHE PROCESS OF TUMOR METASTASISDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Malignant Tumor metastasis pathway 恶性肿瘤常见的转移途径恶性肿瘤常见的转移途径Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Common metastasis pathway 1.lymphaticmetastasis淋巴淋巴道转移道转移2.hematogenousmetastasis血道血道转移转移
5、3.implantationmetastasis种植种植性转移性转移Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Process ： cancer cell lymph vessel regional lymph node beyond lymph node hematogenousmetastasis1.LymphaticmetastasizeDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT 2.HematogenousmetastasisulunglunguliverliverDesigner:S.G.C.ch
6、en8332海. 水. 正. 蓝. 作. 品NEXT Metastasis pathway（1 1） Body vein lung Body vein lung（2 2） Portal vein liver Portal vein liver（3 3） pulmonary veins Total body （ brain 、 bone 、 kidney 、 adrenal glands ） Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT 3.Implantation metastasis ChestCeliacPericardial cavityDesi
7、gner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Bioremediation生物治生物治疗疗uLow side effectsuWide rangeuClear goalDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Mechanism of cell metastasisCell adhesion molecule(CAM)Degradation of extracellular matrixMotility of tumor cellsFormation of vessels Regulation of gene ex
8、pressionImmunizationDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Cell adhesion molecule(CAM)vCadherinvIntegrinsvSelectinvIgSFvothersDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Degradation of extracellular matrix Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT 丝氨酸蛋白酶类丝氨酸蛋白酶类 半胱氨酸蛋白酶类（半胱氨酸蛋白酶类（ Caspase家族）家
9、族）天冬氨酸蛋白酶类天冬氨酸蛋白酶类 基质金属蛋白酶类（基质金属蛋白酶类（MMPs）Degradation of extracellular matrix vProteoiytic enzymes (蛋白水解酶蛋白水解酶)溶解溶解ECMECM是肿瘤侵袭和转移的是肿瘤侵袭和转移的天然屏障天然屏障Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Motility of tumor cells Motility types: Random movement Directional movement Motility factors:Autoecrineparac
10、rineDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Formation of vesselsTumor metastasis relys on the forming of vessels.Brief Introduction to Molecules in Cancer MetastasisThree SectionspTumour angiogenesisp DisaggregationpIntravasationDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Tumour angiogenesis pTu
11、mour angiogenesis has laid the foundation for tumour survival and tumour metastasis .Designer:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT Tumour angiogenesis ActivatedGeneCytokines:VEGF&TNFAdhiesion moleculesDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT DisaggregationBroken downDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT DisaggregationUpaCathepsinsMMPsDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT DisaggregationDiminished adhesivenessProteolytic enzymesDisaggregationDesigner:S.G.C.chen8332海. 水. 正. 蓝. 作. 品NEXT IntravasationShape TransformationTGFMAPSNA1
