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1、FAKComplexPAK PathwayMRLCMLCK(Active)PPGTPGDPMLCARFGAPGDPGTPRacRacCDC42CofilinF-ActinPaxillinTrancriptional Activation and Filopodia FormationLamelliopodia &Filopodia FormationStressStressFibresFibresFocalAdhesionContractilityLamelliopodia &Filopodia OutgrowthPCaspasesCaspases & Caspases & Caspase-L
2、ikeCaspase-LikeProteasesProteasesPAKPaxillinPAKWASPPAKCDC42CDC42PI3KRacLIMKMLCK(Inactive)JNKKMEKK1MLCMyosinPPtaseJNKRhoAMRLCMLCPMyosinPPtaseROCKROCKPDGFRPDGFGrowth FactorGrowth FactorReceptorReceptorMitogen &Mitogen &Growth FactorsGrowth FactorsCell DeathCellSurvivalActivePAK2InactivePAK2 DimerhPIP1
3、MyosinMyosinActivationActivationActinActinCytoskeletonCytoskeletonDepolymerizingDepolymerizingF-ActinF-ActinMyosin-II IIPaxillinDisassemblyRacAIDNESNLSESNLSUbUbAIDNESNLSActinActinOrganizationOrganizationCytokinesCytokinesDSCAMCytokines & Cytokines & Stress FactorsStress FactorsESNLSActivePAK2Ubiquitination &Ubiquitination &DegradationDegradationAIDNUbUbRas 20092009ProteinLProteinLC
