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1、天坛会议血压波动、阵发性高血天坛会议血压波动、阵发性高血压与卒中风险压与卒中风险Limitations of the usual blood-pressure hypothesis and importanceof variability, instability, and episodichypertensionPrognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertensionEffects of antihypertensive-d
2、rug class on interindividual variation in blood pressure and risk of stroke: a systematic review and meta-analysisEffects of beta blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of strokeLancet13th March 2010Lancet 2010；375：895-905UK-TIA研究中平均收缩压及血压波动
3、测量的准确性对其卒中风险关联性的影响UT-TIA研究中收缩压最大值和最小值与继发卒中的相应危险度最大收缩压超过平均收缩压的比例7次测量10次测量0-9%1110-19%1.21（0.69-2.14）2.24（0.67-7.46）20-29%1.84（1.01-3.35）4.10（1.22-13.8）30-39%3.24（1.54-6.78）6.16（1.70-22.4）40%6.21（2.29-16.9）9.31（2.07-41.8）最小收缩压低于平均收缩压的比例0-4%115-9%0.98（0.43-2.25）1.19（0.40-3.52）10-14%0.90（0.39-2.06）1.02（
4、0.35-2.95）15-19%1.72（0.75-3.95）2.17（0.76-6.17）20%1.64（0.66-4.07）2.59（0.91-7.36）Lancet 2010；375：895-905Mean(SD) SBP(mmHg) at baseline and during follow-up stratified by randomised treatment in the ALLHAT trialFollow-upTreatment groupSignificance (p) of difference in SDVisitAmlodipine(A)Chlorthalidone
5、(C)Lisinopril (L)A vs LC vs LBaseline146.2(15.7)146.2(15.7)146.4(15.7)0.50.51 year138.5(14.9)136.9(15.8)140.0(18.5)910-79710-552 years137.1(15.0)135.9(15.9)138.4(17.9)310-48110-283 years135.6(15.2)134.8(15.4)136.7(17.3)910-25210-254 years134.8(15.0)133.9(15.7)135.5(17.2)110-24210-145 years134.7(14.9
6、)133.9(15.2).135.9(17.9)110-24810-25Lancet 2010；375：938-48Lancet Neurol 2010; 9: 469-80Effect of tresment on group SDSBP in ASCOT-BPLAEffect of treatment allocation on visit-to-visit variability in SBP in ASCOTLancet Neurol 2010; 9: 469-80Within-visit CV SBP in ASCOT-BPLAAverage within-individual da
7、ytime SD SBP on repeated ABPM in ASCOT-BPLALancet Neurol 2010; 9: 469-80Group SD SBP in the MRC Trial in elderly hypertensive patientsLancet Neurol 2010; 9: 469-80MRC研究中老年高血压患者的各治疗组的收缩压标准差所有关于降压药物的随机对照临床试验的系统回顾1372个入选的试验研究94个3期临床试验（每组100个随访超过1年的病人）93个试验共计578456例病人各药物间进行荟萃分析比较OR值28组对照共包括188564个病人荟萃分析
8、比较VR及OR377个有随访标准差数据的期临床试验（有9篇报道包括2个试验）685个药物组共计157505人比较VR或%CV的变化361组对照共计150663人不同药物间的VR或%CV的比较910个期临床试验因报道不充分而未入组+21个个期临床试验期临床试验Lancet 2010; 375: 906-15Random effects meta-analysis of cardiovascular outcomes for each drug class versus all other classes combinedPooled estimates of variance ratio between drug classes in parallel group trialsLancet Neurol 2010; 9: 469-80牛津血管研究对TIA或小卒中病人进行随访，每天随访进行3次家庭血液测量（取10分钟内3次测量的平均值），揭示了CCB对个体血压波动的影响。
