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1、Chapter 17 Drugs for the Treatment of Parkinsons Disease and Other Movement DisordersSectionIIIDrugsthatactintheSectionIIIDrugsthatactinthecentralnervoussystemcentralnervoussystemFamous Celebrities with Parkinsons Disease Chen Jingrun Famous Chinese MathematicianMuhammad AliFamous American BoxerDeng
2、 Xiaoping Famous Chinese politicianJames Parkinson James Parkinson James Parkinson James Parkinson (1755-1824) (1755-1824) (1755-1824) (1755-1824)ParkinsonParkinson sDiseasesDisease（ （paralysisparalysisagitansagitans） ）The second most common neurological diseaseIt is usually idiopathic (causes unkno
3、wn)Genetic factor(-synuclein ), aging, and exposure to toxins.There is no cure for the disease by now震颤麻痹震颤麻痹震颤麻痹震颤麻痹Signs and Symptoms of Parkinsons Diseaseresting tremor 静止震颤静止震颤(involuntary movement at rest)short shuffling steps 走路小碎走路小碎步步stooped posture 弯腰驼背弯腰驼背lack of normal automatic or subcon
4、scious movements 随意运动减少随意运动减少Blank face 表情呆板表情呆板 (面具脸面具脸)What happens in Parkinsons disease?Normal: excitatory pathway and inhibitory pathway keep a balance in controlling the motor functionParkinsons Disease: substantial nigra neurons die so the balance is thrown off黑质黑质纹状体纹状体Drug therapyDrug thera
5、pygoal : correct the shortage of dopamine levodopadopamine receptor agonists MAO inhibitors and COMT inhibitors 左旋多巴左旋多巴 溴隐亭溴隐亭普拉克索普拉克索托卡朋托卡朋司来吉兰司来吉兰Drug therapy and OthersDrug therapy and Otherscentral acetylcholine-blocking drugs :trihexyphenidyl 苯海索苯海索 antivirus agent: amantadine 金刚烷胺金刚烷胺Others:O
6、thers: implantation of electrode into brainstem cells are under way Drug therapyDrug therapygoal : correct the shortage of dopamine levodopadopamine receptor agonists MAO inhibitors and COMT inhibitors 左旋多巴左旋多巴 溴隐亭溴隐亭普拉克索普拉克索托卡朋托卡朋司来吉兰司来吉兰2011-05-042011-05-042011-05-042011-05-04Thanks for your attention!Thanks for your attention!
