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1、Review of published papersHu Peng2010-7-20Pierot, L., L. Spelle, and F. Vitry, Immediate clinical outcome of patients harboring unruptured intracranial aneurysms treated by endovascular approach: results of the ATENA study. Stroke, 2008. 39(9): p. 2497-504.ATENA: Analysis of Treatment by Endovascula
2、r approach of Non ruptured Aneurysms.Conducted by the French Society of Neuroradiology (SFNR)27 Canadian and French neurointerventional centers.17 monthsPatients and aneurysm critereaaneurysms less than 15 mm.Excluded aneurysms:Fusiform and dissecting aneurysmsaneurysms associated with brain arterio
3、venous malformationsIn case of recent subarachnoid hemorrhage (1 month) related to another aneurysmClinical outcomes evaluationClinical status: mRSPermanent morbidity and mortality of the treatment was evaluated at 1 month:Morbidity:Asymptomatic aneurysms: mRS 25;Symptomatic aneurysms: mRS previousm
4、ortality:Any death within 30 days of endovascular treatmentAnatomical results:modified 3-point Jean Raymond classification scale:complete occlusion, neck remnant, and aneurysm remnantDescription of patients population and aneurysms24 patients/center649 patients: 468 female patients, 181 male patient
5、s649 patients with 1100 UIAs, 289 patients with multiple UIAs700 procedures were performed to treat 739 aneurysmsAnterior circulation: 91.9%Posterior circulation: 8.1%resultsParent artery occlusion: 12Coils: 727 aneurysms396 aneurysms: coils alone271 aneurysms: remodeling techqiuesStenting: 57Trispa
6、n: 3Feasibility of Endovascular Treatment of Unruptured Intracranial Aneurysms:32 aneurysms failed by endovascular approach;2 patients with multiple UIAs, others ruptured during the procedure;22 because of anatomical reasons:wide neck not controllable with the remodeling technique, vessel arising fr
7、om the neck of the aneurysm, and small size of the aneurysm making deposition of coils difficult and unsafe8 aneurysms: due to technique problems: difficulties in microcather placement14 MCA UIAs failedSize: failure rate: 16mm 5.7% 715mm: 2.3% p=0.022Dome-to-neck ratio: 1.5 3.1%. P=0.57104 adverse e
8、vents:88 sepecific adverse events50 ischemic stroke18 anerysms ruptured20 coil related events16 puncture related eventsFactors affecting the procedure-related problemsNosignificantsignificantNo11 patients: (1.7%)6: ischemic stroke4: aneurysm rupture1: UIAs unrelated hemotoma9 death (1.4%)6: died dur
9、ing or immediately after treatment1: anesthetic complication2: several days after the treatment: intracranial hemotomaFactors Affecting Complications of Endovascular Treatment of Unruptured Intracranial Aneurysms:Ischemic stroke: not significantly different according to the location or dome-to-neck
10、ratio of aneurysms. On the contrary, the rate of thromboembolic events was significantly higher in large-sized aneurysms (1 to 6 mm: 4.6%; 7 to 15 mm: 9.9%; P 0.008).Aneurysm rupture: significantly higher in smaller aneurysms (1 to 6 mm: 3.7%; 7 to 15 mm: 0.7%; P0.008)Comparison between sugery and E
11、VTNo direct comparison in a randomized study availablesingle-center seriesJohnston(1999): significantly higher in the surgical group (18.5%) than in the endovascular group (10.6%). Mortality was 2.3% after clipping and 0.4% after coilingHigashida(2007): endovascular treatment was associated with few
12、er adverse outcomes (6.6% versus 13.2%), decreased mortality (0.9% versus 2.5%)limitationsinclusion biascognitive status of the patients was not evaluatedPierot, L., L. Spelle, and F. Vitry, Immediate anatomic results after the endovascular treatment of unruptured intracranial aneurysms: analysis of the ATENA series. AJNR Am J Neuroradiol, 2010. 31(1): p. 140-4.
