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1、First, two questions.1.Whendoyougetup?2.Whendoyougotobed?The biological clock is warning youThe molecular mechanism of controlling circadian rhythm控制昼夜节律的分子机制Reporter： Zhang Qing2018.06.06Thesunsetbuttherest.（日落而息）Thesunrisemakes.(日出而作) A phenomenon of the circadian rhythm / the biological clock HOW
2、 DOES IT WORK IN GENE? The fruit fly :sleeps during the day howls during the night WHY?The mutation(缺失缺失) of a period gene in the body周期基因HowtoRealizeRegulationofCircadianRhythmprecisly?如何实现昼夜节律的精确调控?WhatIsthePeriodGene?TheTheperperiodgeneencodesaproteincallediodgeneencodesaproteincalledPERPER. .The
3、ThetimtimelessgeneencodesaproteincalledelessgeneencodesaproteincalledTIMTIM. .TheThedouble-timedouble-timegeneencodesaproteincalledgeneencodesaproteincalledDBTDBT. .TheThePERPERproteinwillbetransferredfromproteinwillbetransferredfromthecytoplasm(thecytoplasm(细胞质细胞质)tothenucleus)tothenucleuswiththehe
4、lpofwiththehelpofTIMTIMproteinatnight.proteinatnight.ThePERproteinwillThePERproteinwilldegradedegrade（降解）（降解） duringtheday.duringtheday.TheprocessofaccumulationandTheprocessofaccumulationanddegradationisabout24hours,whichdegradationisabout24hours,whichcorrespondstopeoplesdayandnight.correspondstopeo
5、plesdayandnight.DBTDBTistoslowdowntheaccumulationistoslowdowntheaccumulation（积累）（积累）ofPERprotein,whichallowsofPERprotein,whichallowspreciseregulationofcircadianrhythms.preciseregulationofcircadianrhythms.Openthelockrequirestwokeys,onecalledthePERproteinandtheothercalledaTIM.Thefrequency(频率)ofopening
6、thedooriscontrolledbytheDBTprotein.The process is liked as a lock and a keyFirst, heal some of the genetic diseases（遗传性疾病）. Second, cure insomnia(失眠). Third, reveal the danger of staying up late.WhatisTheUseofThisFinding?At last but not at least, we must let the body rest at the right time. Pay attention to the biological clock, who is warning you!THANK THANK YOU!YOU!
