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1、S312 OFID 2017:4 (Suppl 1) Poster AbstractsSession: 139. Adult Viral InfectionFriday, October 6, 2017: 12:30 PM Background. Human coronaviruses (HCoV) OC43, 229E, NL63 and HKU1 commonly cause upper respiratory tract infections, but can also cause severe lower respiratory tract disease. Increased use
2、 of diagnostic assays for respiratory viruses has facilitated detection and, since 2014, voluntary reporting of HCoV to the National Respiratory and Enteric Virus Surveillance System (NREVSS).Methods. We reviewed weekly aggregate test results for HCoV OC43, 229E, NL63 and HKU1 voluntarily reported t
3、o NREVSS by U.S.hospital and clinical lab-oratories from July 1, 2014April 30, 2017. Laboratories reporting any HCoV result using PCR were included, and the weekly percentage of positive HCoV tests by type was calculated. For a subset of HCoV detections reported to NREVSS via the Public Health labor
4、atory Interoperability Project (PHLIP), which collects individual-level demographic data, we described age distribution and sex. Age distribution by HCoV type was compared using the KruskalWallistest.Results. 154 laboratories, across all 9 U.S. census divisions, reported 834,742 tests for HCoV; 18,5
5、14 (2.2%) were positive for HCoV-OC43, 8,363 (1.0%) for HCoV-NL63, 6,828 (0.8%) for HCoV-229E, and 5,170 (0.6%) for HCoV-HKU1. The percentage of tests positive for HCoV generally peaked between December and March (Figure1). HCoV-OC43 showed distinct annual peaks with variation in magnitude by year.
6、HCoV-HKU1 and NL63 had similar patterns, each with notable peaks during winter 2016 compared with 2015 or 2017. HCoV-229E showed a discernable peak in 2017 compared with the previous 2years. Of 20,533 individuals with HCoV test results reported via PHLIP, 1,589 (7.7%) tested positive for any HCoV; 5
7、0% of HCoV-positive individuals were male, and the median age was 22 (range 096) years. Age distribution differed between HCoV types (P 18years) presenting with respiratory illness in Cleveland,Ohio.Methods. Between February 1, 2016 and April 30, 2017, 2949 nasopharyngeal swab specimens were analyze
8、d by NxTAG Respiratory Pathogen Panel in adults pre-senting with respiratory illness at MetroHealth Medical Center. Clinical data were collected on adults whose samples screened positive for CoV-HKU1, CoV-OC43, CoV-229E or CoV-NL63.Results. Coronaviruses were detected in 192 (6.5%) adults including
9、105 (3.5%) OC43, 67 (2.3%) 229E, 13 (0.4%) HKU1 and 7 (0.2%) NL63. The majority of adults with coronavirus infection were females (66.2%) with a median age of 53 years. Common comorbidities included smoking (40.0%), asthma (38.0%), COPD (35.4%), and inhaled corticosteroid use (28.6%). Eighty-five (4
10、6.4%) required admission to the hospital. Common presenting symptoms included shortness of breath (42.7%) and cough (31.0%) whereas fever was uncommon (12.5%). Gastrointestinal symptoms were more common in HKU1 and NL63 infected adults. Seventy-three percent of coronavirus disease occurred between t
11、he months of January and March. Despite the recognition of coronavirus infection, 70 (36.5%) received antibiotics for their disease.Conclusion. This study provides needed insight into clinical characteristics and severity associated with coronavirus infection in adults. Coronavirus infection should
12、be considered in differential diagnosis of respiratory tract illness in adults including those that require hospitalization, have a history of smoking and have pulmonary comorbidities.Disclosures. All authors: No reported disclosures.1033. Evaluation of Serum TNF-alpha, IL-6, IL-10, and IFN-gamma Le
13、vels in Patients with CrimeanCongo Hemorrhagic FeverHlyaYilmaz, MD1; GrdalYilmaz, Professor2; UgurKostakoglu, Assistant profes-sor3; MustafaArslan, MD4; Sleyman CanerKarahan, Professor5 and IftiharKoksal, Professor2; 1Department of Medical Biochemistry, Health Sciences University, Kanuni Training and Research Hospital, Trabzon, Turkey, 2Department of Infectious Diseases and Clinical Microbiology, Karadeniz Technical University, Medical Faculty, Trabzon, Downloaded from https:/ gueston 13 August 2018
