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1、The reemergence of natural products for drug discovery in the genomics era药物基因组学教研室药物基因组学教研室解鸿波解鸿波Natural products and drug discoveryNatural products and genomicsFuture directions and outlookSources of Natural products1234What are natural products?1. Sources of Natural productsWhat are natural produ
2、cts?1. Sources of Natural productsArtemisinin2. Natural products and drug discoveryMorphineQuininePaclitaxel6%27%25%5%37%All small molecule new chemical entitiesCommerciallyavailablechemical space22 x 106 compoundsNatural product universe16 x 104 compounds Natural-product databasesDatabaseNumber of
3、entriesAdditional informationSuper Natural II355,0002D structures with vendor informationUniversal Natural Product Database197,2013D structures assembled from other databasesChinese Natural Product Database53,000Has been used in virtual screeniSMART20,000From traditional Chinese medicinesAfroDb1,000
4、From African medicinal plantsInteractions between drug and target3. Natural products and genomicsInsights into the BiosynthesisInsights into the BiosynthesisGene clusterBioinformatics toolsantiSMASH 3.0Discover new drug leadsDiscover new drug leadsPromoter replacements and gene deletions4. Future directions and outlook“There was an intrinsic belief in the value of the molecules were seeking.” Gregory Verdine
