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1、ApoptosisintheregulationofImmunecellsPart11234目录CONTENTApoptosisBcl-2Mcl-1BimApoptosisMcl-1Bcl-2BimApoptosisintheregulationofImmunecellsprogrammedcelldeath(PCD)Differentfromnecrosis(坏死)UniversalMcl-1BimBcl-2ApoptosisDispensableDivideinto2types:InhibitionofapoptosiscaspasePromoteapoptosischangemitoch
2、ondrialmembranepermeabilityProapoptoticfactorreleaseregulatecelldeath(apoptosis)Oncogene(DamagetotheBcl-2genehasbeenidentifiedasacauseofanumberofcancers)UniversalBimApoptosisMcl-1Bcl-2mechanismstillnotclearItsBH1combineswiththeBH3ofPuma(akindofproteinwhichalsobelongstoBcl-2andpromoteapoptosis)andsto
3、pthecytochromeCrelaesefrommitochondrioncanstopapoptosiswhentheamountofPumaislow(becaiseofitsinstability)ApoptosisBcl-2Mcl-1BimActivatedBaxorinhibitedBcl-2orbothmakeBH3-onlyproteinbindingtotheBcl2proteintightlybindstotheBH3-onlyproteinwithBidlikeBH3domain,causingmitochondrialpathwayapoptosis.Conclusi
4、onPart2Activation-inducedCellDeath(AICD)Reference:1.Anti-apoptoticMcl-1iscriticalforthesurvivalandniche-fillingcapacityofFoxp3+regulatoryTcells2.ROITTSEssentialImmunology12thEditionCellmembrane:FasL+FasMitochondria:ImbalanceofBcl2Caspase3Caspase8CleavageofICAD-LCADCleavageofDNAFLIPthanksforlistening!